Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Claudio Lotesoriere"'
Autor:
Carmelo Laface, Angela Dalia Ricci, Simona Vallarelli, Carmela Ostuni, Alessandro Rizzo, Francesca Ambrogio, Matteo Centonze, Annalisa Schirizzi, Giampiero De Leonardis, Rosalba D’Alessandro, Claudio Lotesoriere, Gianluigi Giannelli
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7737 (2024)
Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase (ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and catalyzes the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA). L
Externí odkaz:
https://doaj.org/article/74487963409a485b99101e393a73cc42
Autor:
Rosalba D’Alessandro, Maria Grazia Refolo, Annalisa Schirizzi, Giampiero De Leonardis, Rossella Donghia, Vito Guerra, Gianluigi Giannelli, Ivan Roberto Lolli, Maria Maddalena Laterza, Ferdinando De Vita, Caterina Messa, Claudio Lotesoriere
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/bdbbe366da69448e959e5d710e22e3fb
Autor:
Annalisa Schirizzi, Aram Arshadi, Doron Tolomeo, Laura Schirosi, Anna Maria Valentini, Giampiero De Leonardis, Maria Grazia Refolo, Rossella Donghia, Clelia Tiziana Storlazzi, Alfredo Zito, Angela Dalia Ricci, Simona Vallarelli, Carmela Ostuni, Maria Bencivenga, Giovanni De Manzoni, Caterina Messa, Raffaele Armentano, Gianluigi Giannelli, Claudio Lotesoriere, Rosalba D’Alessandro
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2721 (2023)
Metastatic gastric cancer (mGC) often has a poor prognosis and may benefit from a few targeted therapies. Ramucirumab-based anti-angiogenic therapy targeting the VEGFR2 represents a milestone in the second-line treatment of mGC. Several studies on di
Externí odkaz:
https://doaj.org/article/4e8a709cb37c4383a6a564c6da1935bb
Autor:
Annalisa Schirizzi, Marialessandra Contino, Livianna Carrieri, Chiara Riganti, Giampiero De Leonardis, Maria Principia Scavo, Maria Grazia Perrone, Morena Miciaccia, Joanna Kopecka, Maria Grazia Refolo, Claudio Lotesoriere, Nicoletta Depalo, Federica Rizzi, Gianluigi Giannelli, Caterina Messa, Rosalba D’Alessandro
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionPaclitaxel (PTX) interferes with microtubule architecture by binding to β-tubulin, thereby blocking progression at the G2/M phase and inducing apoptosis. This study aimed to investigate molecular processes underlying PTX-mediated resista
Externí odkaz:
https://doaj.org/article/22198d209df840f1b9636ba624d8c711
Autor:
Annalisa Schirizzi, Giampiero De Leonardis, Vincenza Lorusso, Rossella Donghia, Alessandro Rizzo, Simona Vallarelli, Carmela Ostuni, Laura Troiani, Ivan Roberto Lolli, Gianluigi Giannelli, Angela Dalia Ricci, Rosalba D’Alessandro, Claudio Lotesoriere
Publikováno v:
Cancers, Vol 15, Iss 8, p 2376 (2023)
Although biliary tract cancers are traditionally considered rare in Western countries, their incidence and mortality rates are rising worldwide. A better knowledge of the genomic landscape of these tumor types has broadened the number of molecular ta
Externí odkaz:
https://doaj.org/article/4500d1d806564735bd3b01d924cc50ab
Autor:
Rosalba D’Alessandro, Maria Grazia Refolo, Annalisa Schirizzi, Giampiero De Leonardis, Rossella Donghia, Vito Guerra, Gianluigi Giannelli, Ivan Roberto Lolli, Maria Maddalena Laterza, Ferdinando De Vita, Caterina Messa, Claudio Lotesoriere
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The combination of paclitaxel and ramucirumab is the second-line therapy of choice in the treatment of advanced gastric cancer. To date, no biomarkers are available in gastric cancer to predict the outcome of antiangiogenic therapy. The present prosp
Externí odkaz:
https://doaj.org/article/3efbf49ad686441bbde8303cc2189b7f
Autor:
Vittoria Disciglio, Paola Sanese, Candida Fasano, Claudio Lotesoriere, Anna Maria Valentini, Giovanna Forte, Martina Lepore Signorile, Katia De Marco, Valentina Grossi, Ivan Lolli, Filomena Cariola, Cristiano Simone
Publikováno v:
Genes, Vol 13, Iss 4, p 644 (2022)
Genetic variants located in non-coding regions can affect processes that regulate protein expression, functionally contributing to human disease. Germline heterozygous mutations in the non-coding region of the PTEN gene have been previously identifie
Externí odkaz:
https://doaj.org/article/a93999a4ab51409cbcbdf006a6b55ec6
Autor:
Angela Dalia Ricci, Rosalba D'Alessandro, Alessandro Rizzo, Annalisa Schirizzi, Simona Vallarelli, Carmela Ostuni, Laura Troiani, Ivan Roberto Lolli, Claudio Lotesoriere, Gianluigi Giannelli
Publikováno v:
Immunotherapy. 15:477-486
Following the practice-changing results observed in several hematological and solid tumors, immunotherapy with immune checkpoint inhibitors (ICIs) has been tested in cholangiocarcinoma (CCA) patients. However, ICI monotherapy has had disappointing re
Autor:
Rosalba D'Alessandro, Caterina Messa, Maria Grazia Refolo, Maria Gabriella Caruso, Claudio Lotesoriere
Publikováno v:
Journal of Leukocyte Biology. 108:633-646
Gastric cancer (GC) is characterized by extreme heterogeneity due to histopathological differences, molecular characteristics, and immune gene expression signature. Until recently, several targeted therapies failed due to this complexity. The recent
Autor:
Alessandro Stella, Martina Lepore Signorile, Ivan Lolli, Valentina Grossi, Candida Fasano, Claudio Lotesoriere, Filomena Cariola, Nicoletta Resta, Vittoria Disciglio, Cristiano Simone, Giovanna Forte, Paola Sanese
Publikováno v:
Journal of Medical Genetics
Germline mutations of the APC gene, which encodes a multidomain protein of 2843 amino acid residues, cause familial adenomatous polyposis (FAP). Three FAP clinical variants are correlated with the location of APC mutations: (1) classic FAP with profu