Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Claudio Humeres"'
Autor:
Ruoshui Li, Bijun Chen, Akihiko Kubota, Anis Hanna, Claudio Humeres, Silvia C. Hernandez, Yang Liu, Richard Ma, Izabela Tuleta, Shuaibo Huang, Harikrishnan Venugopal, Fenglan Zhu, Kai Su, Jun Li, Jinghang Zhang, Deyou Zheng, Nikolaos G. Frangogiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Macrophages sense changes in the extracellular matrix environment through the integrins and play a central role in regulation of the reparative response after myocardial infarction. Here we show that macrophage integrin α5 protects the infa
Externí odkaz:
https://doaj.org/article/2c80b06b17ca43dea72a0bd195b86518
Autor:
Claudio Humeres, Arti V. Shinde, Anis Hanna, Linda Alex, Silvia C. Hernández, Ruoshui Li, Bijun Chen, Simon J. Conway, Nikolaos G. Frangogiannis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts. However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to prevent excessive fibrosis and adverse remodeling that may precipitat
Externí odkaz:
https://doaj.org/article/cf5b1c6e35dd4f71ae1a816c353b45b6
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 449-467 (2019)
Summary: Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling m
Externí odkaz:
https://doaj.org/article/d5df0791839442adaecce125cd72ef3d
Publikováno v:
Cells, Vol 11, Iss 9, p 1386 (2022)
The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that expand following injury and play a reparative role but also contribute to maladaptive fibrotic remodeling. Following myocardial infarction, cardiac fibroblasts
Externí odkaz:
https://doaj.org/article/9f9214ad172742e092a66b7c72c8782c
Autor:
Samir Bolívar, Renatto Anfossi, Claudio Humeres, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jimenez, Francisco Olivares-Silva, Guillermo Díaz-Araya
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Cardiac fibroblasts (CFs) contribute to theinflammatory response to tissue damage, secreting both pro- and anti-inflammatory cytokines and chemokines. Interferon beta (IFN-β) induces the phosphorylation of signal transducer and activator of transcri
Externí odkaz:
https://doaj.org/article/a94bb2cf49204d6a897d332ae9ee6d15
Publikováno v:
Cardiac Mechanobiology in Physiology and Disease ISBN: 9783031239649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf69945945c231273c2d4d7587d84a7
https://doi.org/10.1007/978-3-031-23965-6_4
https://doi.org/10.1007/978-3-031-23965-6_4
Autor:
Jun Li, Ruoshui Li, Izabela Tuleta, Silvia C. Hernandez, Claudio Humeres, Anis Hanna, Bijun Chen, Nikolaos G. Frangogiannis
Publikováno v:
FASEB J
Smad7 restrains TGF-β responses, and has been suggested to exert both pro- and anti-inflammatory actions that may involve effects on macrophages. Myocardial infarction triggers a macrophage-driven inflammatory response that not only plays a central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee06bc3ea6f503bc5b1e20426b092c1b
https://europepmc.org/articles/PMC9216182/
https://europepmc.org/articles/PMC9216182/
Autor:
Anis Hanna, Linda Alex, Prasanth Balasubramanian, Arti V. Shinde, Ruoshui Li, Nikolaos G. Frangogiannis, Claudio Humeres
Publikováno v:
Matrix Biol
Tissue injury results in profound alterations in the collagen network, associated with unfolding of the collagen triple helix, proteolytic degradation and generation of fragments. In the infarcted myocardium, changes in the collagen network are criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c818efb007e04cebffa0bc96a9a1fa
https://doi.org/10.1016/j.matbio.2021.05.005
https://doi.org/10.1016/j.matbio.2021.05.005
Publikováno v:
Immune Cells, Inflammation, and Cardiovascular Diseases ISBN: 9781003280767
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3fc9af4b0a5f9c1dfd0bd9f9a1e5a7
https://doi.org/10.1201/b22824-5
https://doi.org/10.1201/b22824-5
Publikováno v:
Circulation Research. 129
Abundant macrophages infiltrate the infarcted heart and play a critical role in repair, remodeling and fibrosis. Macrophages sense changes in the extracellular matrix (ECM) environment through Integrins, thus activating signaling pathways that regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a050a59ad99ab116925d6c27a6759b74
https://doi.org/10.1161/res.129.suppl_1.mp225
https://doi.org/10.1161/res.129.suppl_1.mp225