Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Claudio Grosman"'
Autor:
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, Claudio Grosman, J. Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22763-3
Externí odkaz:
https://doaj.org/article/5f3c02a8eb9b470586e8a12298ff5f39
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(44)
The pathophysiological mechanisms underlying the constellation of symptoms that characterize COVID-19 are only incompletely understood. In an effort to fill these gaps, a “nicotinic hypothesis,” which posits that nicotinic acetylcholine receptors
Autor:
Claudio Grosman, Nicole Godellas
Publikováno v:
The Journal of general physiology. 154(6)
Although the functional properties of ion channels are most accurately assessed using electrophysiological approaches, a number of experimental situations call for alternative methods. Here, working on members of the pentameric ligand-gated ion-chann
Publikováno v:
Proc Natl Acad Sci U S A
Although it has long been proposed that membrane proteins may contain tightly bound lipids, their identity, the structure of their binding sites, and their functional and structural relevance have remained elusive. To some extent, this is because tig
A Crucial Role for Side-Chain Conformation in the Versatile Charge Selectivity of Cys-Loop Receptors
Autor:
Claudio Grosman, Tyler J. Harpole
Publikováno v:
Biophys J
Whether synaptic transmission is excitatory or inhibitory depends, to a large extent, on whether the ion channels that open upon binding the released neurotransmitter conduct cations or anions. The mechanistic basis of the opposite charge selectiviti
Autor:
Yulong Li, Santhosh Sethuramanujam, Geoff deRosenroll, J. Michael McIntosh, Akihiro Matsumoto, Claudio Grosman, Gautam B. Awatramani, Keisuke Yonehara, Benjamin L Murphy-Baum, David M. Berson, Miao Jing
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22763-3
Autor:
Claudio Grosman, Gisela D. Cymes
Publikováno v:
Proc Natl Acad Sci U S A
One of the most fundamental questions in the field of Cys-loop receptors (pentameric ligand-gated ion channels, pLGICs) is how the affinity for neurotransmitters and the conductive/nonconductive state of the transmembrane pore are correlated despite
Autor:
Gautam B. Awatramani, Geoff deRosenroll, J. Michael McIntosh, Santhosh Sethuramanujam, Claudio Grosman, Miao Jing, David M. Berson, Akihiro Matsumoto, Yulong Li, Keisuke Yonehara, Benjamin L Murphy-Baum
Publikováno v:
Nature Communications
Sethuramanujam, S, Matsumoto, A, deRosenroll, G, Murphy-Baum, B, McIntosh, J M, Jing, M, Li, Y, Berson, D, Yonehara, K & Awatramani, G B 2021, ' Rapid multi-directed cholinergic transmission in the central nervous system ', Nature Communications, vol. 12, no. 1, 1374 . https://doi.org/10.1038/s41467-021-21680-9
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Sethuramanujam, S, Matsumoto, A, deRosenroll, G, Murphy-Baum, B, McIntosh, J M, Jing, M, Li, Y, Berson, D, Yonehara, K & Awatramani, G B 2021, ' Rapid multi-directed cholinergic transmission in the central nervous system ', Nature Communications, vol. 12, no. 1, 1374 . https://doi.org/10.1038/s41467-021-21680-9
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In many parts of the central nervous system, including the retina, it is unclear whether cholinergic transmission is mediated by rapid, point-to-point synaptic mechanisms, or slower, broad-scale ‘non-synaptic’ mechanisms. Here, we characterized t
Autor:
Emad Tajkhorshid, Claudio Grosman, Zhiyu Zhao, Gisela D. Cymes, Zhening Zhang, Pramod Kumar, Yuhang Wang
Publikováno v:
Proc Natl Acad Sci U S A
The lipid dependence of the nicotinic acetylcholine receptor from the Torpedo electric organ has long been recognized, and one of the most consistent experimental observations is that, when reconstituted in membranes formed by zwitterionic phospholip
Publikováno v:
The Journal of General Physiology
Members of the pentameric ligand-gated ion channel family have been crystallized in different conformations, including one in which the transmembrane pore is surprisingly wide. Gonzalez-Gutierrez et al. show that the open-channel conformation of anim