Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Claudio Giachino"'
Autor:
Pascal Forcella, Niklas Ifflander, Chiara Rolando, Elli-Anna Balta, Aikaterini Lampada, Claudio Giachino, Tanzila Mukhtar, Thomas Bock, Verdon Taylor
Publikováno v:
eLife, Vol 13 (2024)
Neural stem cells (NSCs) are multipotent and correct fate determination is crucial to guarantee brain formation and homeostasis. How NSCs are instructed to generate neuronal or glial progeny is not well understood. Here, we addressed how murine adult
Externí odkaz:
https://doaj.org/article/c62f42c3773d4eb489e0343720bc40a9
Autor:
Anna Engler, Chiara Rolando, Claudio Giachino, Ichiko Saotome, Andrea Erni, Callum Brien, Runrui Zhang, Ursula Zimber-Strobl, Freddy Radtke, Spyros Artavanis-Tsakonas, Angeliki Louvi, Verdon Taylor
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 992-1002 (2018)
Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RM
Externí odkaz:
https://doaj.org/article/1d7b97039e0342b68859ae10b6f89350
Publikováno v:
Cells, Vol 9, Iss 10, p 2304 (2020)
Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH signaling is also implicated in multiple cancers by either promoting or suppr
Externí odkaz:
https://doaj.org/article/6b78fb432c2443689257307bd7069e4d
Autor:
Jan S Tchorz, Thomas Suply, Iwona Ksiazek, Claudio Giachino, Dimitri Cloëtta, Claus-Peter Danzer, Thierry Doll, Andrea Isken, Marianne Lemaistre, Verdon Taylor, Bernhard Bettler, Bernd Kinzel, Matthias Mueller
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30011 (2012)
Generation of gain-of-function transgenic mice by targeting the Rosa26 locus has been established as an alternative to classical transgenic mice produced by pronuclear microinjection. However, targeting transgenes to the endogenous Rosa26 promoter re
Externí odkaz:
https://doaj.org/article/d25336e0939a49ddbdb49a78de491c5a
Autor:
Nicola Aceto, Randall J. Platt, Timm Schroeder, Claudio Giachino, Verdon Taylor, Christoph Rochlitz, Marcus Vetter, Leo Kunz, Tatjana Vlajnic, Simone Muenst, Zoi Diamantopoulou, Barbara M. Szczerba, Sofia Gkountela, Cinzia Donato, Ramona Scherrer, Aino Paasinen-Sohns, Ilona Krol, Karin Strittmatter, Francesc Castro-Giner, Manuel C. Scheidmann
Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation of circulating tumor cells (CTC), and adaptation in various distant metastatic sites. The g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d089ec90c9d9d5016ec75589de1da40
https://doi.org/10.1158/0008-5472.c.6513747.v1
https://doi.org/10.1158/0008-5472.c.6513747.v1
Autor:
Nicola Aceto, Randall J. Platt, Timm Schroeder, Claudio Giachino, Verdon Taylor, Christoph Rochlitz, Marcus Vetter, Leo Kunz, Tatjana Vlajnic, Simone Muenst, Zoi Diamantopoulou, Barbara M. Szczerba, Sofia Gkountela, Cinzia Donato, Ramona Scherrer, Aino Paasinen-Sohns, Ilona Krol, Karin Strittmatter, Francesc Castro-Giner, Manuel C. Scheidmann
Supplementary Table from An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ec14b7ae2331fab6c94f7e0174a5bd
https://doi.org/10.1158/0008-5472.22430934.v1
https://doi.org/10.1158/0008-5472.22430934.v1
Autor:
Nicola Aceto, Randall J. Platt, Timm Schroeder, Claudio Giachino, Verdon Taylor, Christoph Rochlitz, Marcus Vetter, Leo Kunz, Tatjana Vlajnic, Simone Muenst, Zoi Diamantopoulou, Barbara M. Szczerba, Sofia Gkountela, Cinzia Donato, Ramona Scherrer, Aino Paasinen-Sohns, Ilona Krol, Karin Strittmatter, Francesc Castro-Giner, Manuel C. Scheidmann
Supplementary Figure from An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176b311f7743882a50f8ba2d1821d135
https://doi.org/10.1158/0008-5472.22430952.v1
https://doi.org/10.1158/0008-5472.22430952.v1
Autor:
Elena Parmigiani, Claudio Giachino
Publikováno v:
Cancers; Volume 14; Issue 21; Pages: 5409
Simultaneous genetic inactivation of the key Notch signaling mediator RBP-Jk and p53 leads to the formation of forebrain tumors in mice, suggesting a tumor suppressor role of the Notch pathway in this context. However, the contribution of individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c6015157bd2af0487d021162bf6106
Autor:
Elena, Parmigiani, Claudio, Giachino
Publikováno v:
Cancers. 14(21)
Simultaneous genetic inactivation of the key Notch signaling mediator RBP-Jk and p53 leads to the formation of forebrain tumors in mice, suggesting a tumor suppressor role of the Notch pathway in this context. However, the contribution of individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9732f70148ddee88efb51b496104cb1b
https://pubmed.ncbi.nlm.nih.gov/36358826
https://pubmed.ncbi.nlm.nih.gov/36358826
Autor:
Elena Parmigiani, Robert Ivanek, Chiara Rolando, Katrin Hafen, Gleb Turchinovich, Frank Michael Lehmann, Alexandra Gerber, Sime Brkic, Stephan Frank, Sara C. Meyer, Hiroaki Wakimoto, Murat Günel, Angeliki Louvi, Luigi Mariani, Daniela Finke, Georg Holländer, Gregor Hutter, Roxane Tussiwand, Verdon Taylor, Claudio Giachino
Publikováno v:
Parmigiani, Elena; Ivanek, Robert; Rolando, Chiara; Hafen, Katrin; Turchinovich, Gleb; Lehmann, Frank Michael; Gerber, Alexandra; Brkic, Sime; Frank, Stephan; Meyer, Sara C; Wakimoto, Hiroaki; Günel, Murat; Louvi, Angeliki; Mariani, Luigi; Finke, Daniela; Holländer, Georg; Hutter, Gregor; Tussiwand, Roxane; Taylor, Verdon and Giachino, Claudio (2022). Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells. Developmental cell, 57(15), 1847-1865.e9. Elsevier 10.1016/j.devcel.2022.06.006
Immune surveillance is critical to prevent tumorigenesis. Gliomas evade immune attack, but the underlying mechanisms remain poorly understood. We show that glioma cells can sustain growth independent of immune system constraint by reducing Notch sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45035fd081db9ea4f87176308feb7e78