Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Claudio E. Sunkel"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
During mitosis, the interaction of kinetochores (KTs) with microtubules (MTs) drives chromosome congression to the spindle equator and supports the segregation of sister chromatids. Faithful genome partition critically relies on the ability of chromo
Externí odkaz:
https://doaj.org/article/de67f044e85f43419e96c65fce0c7fce
Publikováno v:
Biology Open, Vol 10, Iss 11 (2021)
Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context. Using the Drosophila midgut as a model, we have recently
Externí odkaz:
https://doaj.org/article/56a7aaba95514580babe5b4663642c45
Autor:
Sofia Moreira, Mariana Osswald, Guilherme Ventura, Margarida Gonçalves, Claudio E. Sunkel, Eurico Morais-de-Sá
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 293-301.e7 (2019)
Summary: Apical-basal polarity is a common trait that underlies epithelial function. Although the asymmetric distribution of cortical polarity proteins works in a functioning equilibrium, it also retains plasticity to accommodate cell division, durin
Externí odkaz:
https://doaj.org/article/5668e73ccd674ef5ac1e145ffef777ec
Autor:
Margarida Moura, Mariana Osswald, Nelson Leça, João Barbosa, António J Pereira, Helder Maiato, Claudio E Sunkel, Carlos Conde
Publikováno v:
eLife, Vol 6 (2017)
Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spindle microtubules. Mps1 kinase is an upstream SAC re
Externí odkaz:
https://doaj.org/article/dacb7870750340888fd3db6fd4f6a433
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
During mitosis, the interaction of kinetochores (KTs) with microtubules (MTs) drives chromosome congression to the spindle equator and supports the segregation of sister chromatids. Faithful genome partition critically relies on the ability of chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc122c4844b14c5fcfe727459efe13
https://pubmed.ncbi.nlm.nih.gov/35155423
https://pubmed.ncbi.nlm.nih.gov/35155423
Publikováno v:
Cell Cycle
To maintain genome stability, chromosomes must be equally distributed among daughter cells at the end of mitosis. The accuracy of chromosome segregation requires sister-kinetochores to stably attach to microtubules emanating from opposite spindle pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b452ce67a0b01a0b8f5b8e15cca34867
https://europepmc.org/articles/PMC7469663/
https://europepmc.org/articles/PMC7469663/
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Aneuploidy is associated with different human diseases including cancer. However, different cell types appear to respond differently to aneuploidy, either by promoting tumorigenesis or causing cell death. We set out to study the behavior of adult Dro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c07936b2f86071f2e3bc6496cb3f92d
https://doi.org/10.1083/jcb.201804205
https://doi.org/10.1083/jcb.201804205
Publikováno v:
EMBO J
Accurate chromosome segregation in mitosis requires sister kinetochores to bind to microtubules from opposite spindle poles. The stability of kinetochore-microtubule attachments is fine-tuned to prevent or correct erroneous attachments while preservi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfdcbd2596941f74106a5b99f788f80
https://pubmed.ncbi.nlm.nih.gov/31849090
https://pubmed.ncbi.nlm.nih.gov/31849090
Autor:
Marta S. Oliveira, Jaime Freitas, Alexandra Moreira, Mafalda Pinho, Carla Lopes, Claudio E. Sunkel, Rita G. Domingues, Carlos Conde, Pedro A B Pinto, Joana Tavares, Telmo Henriques, Ana de Jesus
Publikováno v:
Molecular and Cellular Biology. 39
Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3′ untr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6094a800c000af95ff4ec7d5dd78d3ad
https://doi.org/10.1128/mcb.00581-18
https://doi.org/10.1128/mcb.00581-18
Publikováno v:
Cell Cycle
The development of multicellular organisms and the maintenance of its tissues relies on mitosis. However, this process represents a major challenge for genomic stability as each time a cell division occurs there are multiple steps where errors can le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f498abbacc7ea9200ac6c4dc691464ab
https://europepmc.org/articles/PMC6681780/
https://europepmc.org/articles/PMC6681780/