Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice.

Autor: Sabata Pierno, Giulia M Camerino, Maria Cannone, Antonella Liantonio, Michela De Bellis, Claudio Digennaro, Gianluca Gramegna, Annamaria De Luca, Elena Germinario, Daniela Danieli-Betto, Romeo Betto, Gabriella Dobrowolny, Emanuele Rizzuto, Antonio Musarò, Jean-François Desaphy, Diana Conte Camerino

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65167 (2014)

Slow-twitch muscles, devoted to postural maintenance, experience atrophy and weakness during muscle disuse due to bed-rest, aging or spaceflight. These conditions impair motion activities and can have survival implications. Human and animal studies d

Externí odkaz: https://doaj.org/article/b0203ce308234f34993e2c302144d8d8

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Autor: Antonietta Mele, Annamaria De Luca, Jean-François Desaphy, Claudio Digennaro, Luciano Villanova, Jean-Francois Rolland, Alessandro Merendino, Diana Conte Camerino, Gianpatrizio Bianco, Antonella Liantonio, Domenico Tricarico, Sabata Pierno, Giulia Maria Camerino

Publikováno v: Age (Dordrecht, Netherlands). 36(1)

Age-related skeletal muscle decline is characterized by the modification of sarcolemma ion channels important to sustain fiber excitability and to prevent metabolic dysfunction. Also, calcium homeostasis and contractile function are impaired. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0096f63cc4a407c4658b43d879ddf1b3
https://pubmed.ncbi.nlm.nih.gov/23716142

Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles

Autor: Jean-François Desaphy, Patrizia Ricciuti, Maria Maddalena Dinardo, Sabata Pierno, Giulia Maria Camerino, Lorenza Brocca, Viviana Giannuzzi, Maria Antonietta Pellegrino, Roberto Bottinelli, Antonella Liantonio, Claudio Digennaro, Diana Conte Camerino

Publikováno v: Pharmacological research. 61(6)

Oxidative stress was proposed as a trigger of muscle impairment in various muscle diseases. The hindlimb-unloaded (HU) rodent is a model of disuse inducing atrophy and slow-to-fast transition of postural muscles. Here, mice unloaded for 14 days were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d244e810bee877071d43c62b292e788a
https://pubmed.ncbi.nlm.nih.gov/20116431

Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice

Autor: Antonella Liantonio, Gianluca Gramegna, Romeo Betto, Elena Germinario, Emanuele Rizzuto, Daniela Danieli-Betto, Antonio Musarò, Annamaria De Luca, Jean-François Desaphy, Claudio Digennaro, Diana Conte Camerino, Gabriella Dobrowolny, Giulia Maria Camerino, Maria Cannone, Sabata Pierno, Michela De Bellis

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 8 (6), pp.e65167. ⟨10.1371/journal.pone.0065167⟩
PLoS ONE, Vol 8, Iss 6, p e65167 (2014)

International audience; Slow-twitch muscles, devoted to postural maintenance, experience atrophy and weakness during muscle disuse due to bed-rest, aging or spaceflight. These conditions impair motion activities and can have survival implications. Hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac3f1df0ba04280663dd44b3bef6d75
https://doi.org/10.1371/journal.pone.0065167