Pro-resolving lipid mediator lipoxin A 4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

Autor: Alessandro Leuti, Paul C. Norris, Gaby Enzmann, Gijs Kooij, Silvia Tietz, Marijn Schouten, Valerio Chiurchiù, Britta Engelhardt, Susanne M. A. van der Pol, Charles N. Serhan, Neda Haghayegh Jahromi, Alwin Kamermans, Claudio Derada Troletti, Helga E. de Vries

Publikováno v: Cell reports (2021). doi:10.1016/j.celrep.2021.109201
info:cnr-pdr/source/autori:Claudio Derada Troletti 1, Gaby Enzmann 2, Valerio Chiurchiù 3, Alwin Kamermans 4, Silvia Martina Tietz 2, Paul C Norris 5, Neda Haghayegh Jahromi 2, Alessandro Leuti 6, Susanne M A van der Pol 4, Marijn Schouten 4, Charles N Serhan 5, Helga E de Vries 4, Britta Engelhardt 2, Gijs Kooij 7/titolo:Pro-resolving lipid mediator lipoxin A 4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome/doi:10.1016%2Fj.celrep.2021.109201/rivista:Cell reports/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Derada Troletti, C, Enzmann, G, Chiurchiù, V, Kamermans, A, Tietz, S M, Norris, P C, Jahromi, N H, Leuti, A, van der Pol, S M A, Schouten, M, Serhan, C N, de Vries, H E, Engelhardt, B & Kooij, G 2021, ' Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome ', Cell Reports, vol. 35, no. 9, 109201 . https://doi.org/10.1016/j.celrep.2021.109201
Derada Troletti, Claudio; Enzmann, Gaby; Chiurchiù, Valerio; Kamermans, Alwin; Tietz, Silvia Martina; Norris, Paul C; Haghayegh Jahromi, Neda; Leuti, Alessandro; van der Pol, Susanne M A; Schouten, Marijn; Serhan, Charles N; de Vries, Helga E; Engelhardt, Britta; Kooij, Gijs (2021). Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell reports, 35(9), p. 109201. Cell Press 10.1016/j.celrep.2021.109201
Cell Reports, 35(9):109201. Cell Press

The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0958f3128127b1bba5858f5cc0149cc0

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Autor: Alessandro Leuti, Paul C. Norris, Gijs Kooij, Serena Ruggieri, Susanne M. A. van der Pol, Stephania Libreros, Nicola Biagio Mercuri, Bert van het Hof, Helga E. de Vries, Gisella Guerrera, Maria Albanese, Valerio Chiurchiù, Ian R. Riley, Diego Centonze, Yoëlle Schell, Claudio Derada Troletti, Luca Battistini, Fabio Buttari, Claudio Gasperini, Charles N. Serhan

Publikováno v: Haematologica

Chronic inflammation is a key pathological hallmark of multiple sclerosis and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators, is impaired. Here, through targeted-metabololipidomics in peripheral bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ea36e34036b16ff5daca8e14950a22
http://hdl.handle.net/11573/1408812

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner

Autor: Ruud D. Fontijn, Wendy W. Unger, Dirk Geerts, Marc Charabati, Claudio Derada Troletti, Bert van het Hof, Susanne M. A. van der Pol, Elizabeth Gowing, Alexandre Prat, Melissa A. Lopes Pinheiro, Helga E. de Vries

Publikováno v: Derada Troletti, C, Lopes Pinheiro, M A, Charabati, M, Gowing, E, van het Hof, B, van der Pol, S M A, Geerts, D, Prat, A, Fontijn, R D, Unger, W W & de Vries, H E 2018, ' Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner ', Brain, Behavior, and Immunity, vol. 69, pp. 48-56 . https://doi.org/10.1016/j.bbi.2017.12.016, https://doi.org/10.1016/j.bbi.2017.12.016
Brain Behavior & Immunity, 69, 48-56. Academic Press
Brain, behavior, and immunity, 69, 48-56. Academic Press Inc.
Brain, Behavior, and Immunity, 69, 48-56. Academic Press Inc.

The blood-brain barrier (BBB) assures brain homeostasis through the specialized function of brain endothelial cells (BECs). Dysfunction of the BBB due to inflammatory processes is associated with several neurological disorders, including multiple scl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7feb0e8f23b13c1972f0689c881dd494
https://research.vumc.nl/en/publications/f7c27b95-85e7-487b-a3e4-2f25bfb00982

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Autor: Shamol Saha, Klodjan Stafa, Allison Citro, Hu Li, Patrick Aebischer, Rina Bandopadhyay, Joon Y. Boon, Maria Guillily, Marcie A. Glicksman, Benjamin Wolozin, Claudio Derada Troletti, Zhenyu Yue, Adamantios Mamais, Min Liu, James J. Collins, Katherine L. Youmans, Julien Dusonchet, Darren J. Moore, Li Qun Liu, Bernard L. Schneider, Liliane Glauser

Publikováno v: Human molecular genetics

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b397110c5e0daa2619e18ae79ac61bb8
https://pubmed.ncbi.nlm.nih.gov/24794857