Proteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implications for their clinical use

Autor: Matteo Calligaris, Giovanni Zito, Rosalia Busà, Matteo Bulati, Gioacchin Iannolo, Alessia Gallo, Anna Paola Carreca, Nicola Cuscino, Salvatore Castelbuono, Claudia Carcione, Claudio Centi, Giandomenico Amico, Alessandro Bertani, Cinzia Maria Chinnici, Pier Giulio Conaldi, Simone Dario Scilabra, Vitale Miceli

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Mesenchymal stromal/stem cells (MSCs) are a heterogeneous population of multipotent cells that can be obtained from various tissues, such as dental pulp, adipose tissue, bone marrow and placenta. MSCs have gained importance in the field of regenerati

Externí odkaz: https://doaj.org/article/2c22fd740e34499aa84df7c75f8425dc

Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Priming Strategy to Improve Their Properties

Autor: Alessia Gallo, Nicola Cuscino, Flavia Contino, Matteo Bulati, Mariangela Pampalone, Giandomenico Amico, Giovanni Zito, Claudia Carcione, Claudio Centi, Alessandro Bertani, Pier Giulio Conaldi, Vitale Miceli

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 863, p 863 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 863

Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these cells are expanded in two-dimensional (2D) cultures, and, in that cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72f027743d654c7625750d0706f4904
http://hdl.handle.net/10447/555566