Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Claudio Catalano"'
Autor:
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation ha
Externí odkaz:
https://doaj.org/article/1f2680b79836478cba894b08e1a585a6
Autor:
Nhi L. Tran, Skerdi Senko, Kyle W. Lucier, Ashlyn C. Farwell, Sabrina M. Silva, Phat V. Dip, Nicole Poweleit, Giovanna Scapin, Claudio Catalano
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4528 (2024)
Membrane proteins constitute about 20% of the human proteome and play crucial roles in cellular functions. However, a complete understanding of their structure and function is limited by their hydrophobic nature, which poses significant challenges in
Externí odkaz:
https://doaj.org/article/ec8c4682b1874cbebedbfe50a2da50e2
Autor:
Mohammed H. AL Mughram, Claudio Catalano, Noah B. Herrington, Martin K. Safo, Glen E. Kellogg
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The aliphatic hydrophobic amino acid residues—alanine, isoleucine, leucine, proline and valine—are among the most common found in proteins. Their structural role in proteins is seemingly obvious: engage in hydrophobic interactions to stabilize se
Externí odkaz:
https://doaj.org/article/f2ff01d0b7c34a5fa6fa2a27bb25f10f
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 239-256 (2021)
Atomic-resolution protein structural models are prerequisites for many downstream activities like structure-function studies or structure-based drug discovery. Unfortunately, this data is often unavailable for some of the most interesting and therape
Externí odkaz:
https://doaj.org/article/4ea46406e60e4f8bbf12f326f9a66320
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100055- (2021)
Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected experimental
Externí odkaz:
https://doaj.org/article/5aa080215e094a3ea3907a6adbe898f8
Autor:
Limin Yang, Claudio Catalano, Yunyao Xu, Weihua Qiu, Dongyu Zhang, Ann McDermott, Youzhong Guo, Paul Blount
Publikováno v:
BBA Advances, Vol 1, Iss , Pp 100011- (2021)
Proteoliposomes mimic the cell membrane environment allowing for structural and functional membrane protein analyses as well as antigen presenting and drug delivery devices. To make proteoliposomes, purified functional membrane proteins are required.
Externí odkaz:
https://doaj.org/article/4ae51f37a0f748b5b91891233552e71f
Publikováno v:
Membranes, Vol 11, Iss 11, p 849 (2021)
Mechanosensitive channels respond to mechanical forces exerted on the cell membrane and play vital roles in regulating the chemical equilibrium within cells and their environment. High-resolution structural information is required to understand the g
Externí odkaz:
https://doaj.org/article/d6ef261896024b6c834f3ab697fff4a4
Autor:
Amedee des Georges, Zephan Melville, Youzhong Guo, Harsh Bansia, Claudio Catalano, Andrew R. Marks
Publikováno v:
Microscopy and Microanalysis. 27:1690-1694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f44a9f78c5c08c167a160edae1a6480
https://doi.org/10.1017/s1431927621006206
https://doi.org/10.1017/s1431927621006206
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss, Pp 239-256 (2021)
Current Research in Structural Biology
Current Research in Structural Biology
Atomic-resolution protein structural models are prerequisites for many downstream activities like structure-function studies or structure-based drug discovery. Unfortunately, this data is often unavailable for some of the most interesting and therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fa428c48d272b37e653a4e98fcc73c
http://www.sciencedirect.com/science/article/pii/S2665928X21000209
http://www.sciencedirect.com/science/article/pii/S2665928X21000209
Membrane proteins are a ubiquitous group of bio-macromolecules responsible for many crucial biological processes and serve as drug targets for a wide range of modern drugs. Detergent-free technologies such as styrene-maleic acid lipid particles (SMAL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21602fa0eb8b3d816e56a531a88ab20f
https://doi.org/10.1101/2022.01.10.475744
https://doi.org/10.1101/2022.01.10.475744
