Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Claudio Basilico"'
Autor:
Eunjeong Seo, Upal Basu-Roy, Preethi H. Gunaratne, Cristian Coarfa, Dae-Sik Lim, Claudio Basilico, Alka Mansukhani
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2075-2087 (2013)
The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but few regulators of self-renewal and early cell-fate decisions are known. Here, we show that the Hippo pathway effector YAP1 is a direct target of SOX2 and can compe
Externí odkaz:
https://doaj.org/article/a6ac577f0b234f638b9345dd6315517e
Publikováno v:
Bio-Protocol, Vol 2, Iss 24 (2012)
Osteosarcomas are the most common primary, non-hematologic malignant tumors in childhood and adolescence, comprising almost 60% of all bone sarcomas. Although these tumors are osteoblastic in nature, the characteristics of the specific tumor-initiati
Externí odkaz:
https://doaj.org/article/280a0509e3ad4b6ea755e815dca3f9dc
Publikováno v:
Bio-Protocol, Vol 2, Iss 24 (2012)
Self-renewing cells from adult tissue (such as bone) that represent a progenitor population can be grown in suspension cultures in the presence of defined serum-free medium. Progenitor cells can be identified by this property of anchorage-independent
Externí odkaz:
https://doaj.org/article/eb91a81fa2304aac864170c6789b03bd
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3447 (2008)
FGF signaling inhibits chondrocyte proliferation, a cell type-specific response that is the basis for several genetic skeletal disorders caused by activating FGFR mutations. This phenomenon requires the function of the p107 and p130 members of the Rb
Externí odkaz:
https://doaj.org/article/6210f1ce4e6c494ea4409528203f8adc
Publikováno v:
Stem Cells. 35:2340-2350
The transcription factor (TF) yes-associated protein 1 (YAP1) is a major effector of the tumor suppressive Hippo signaling pathway and is also necessary to maintain pluripotency in embryonic stem cells. Elevated levels of YAP1 expression antagonize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42f2a348090eba0d0bf9c340d2bbcae
https://doi.org/10.1002/stem.2705
https://doi.org/10.1002/stem.2705
Autor:
Victoria Kolupaeva, Claudio Basilico, Rachel Ruoff, David Morgenstern, Shruti Nayak, Olga Katsara, Beatrix Ueberheide, Jessica R. Chapman
Publikováno v:
Molecular & Cellular Proteomics. 16:1126-1137
Fibroblast growth factor (FGF) signaling is vital for many biological processes, beginning with development. The importance of FGF signaling for skeleton formation was first discovered by the analysis of genetic FGFR mutations which cause several bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea18b2847f32b9c386288d09e4455c2
https://doi.org/10.1074/mcp.m116.064980
https://doi.org/10.1074/mcp.m116.064980
Autor:
Upal Basu-Roy, Kirk Rattanakorn, Preethi H. Gunaratne, Oran D. Kennedy, Giulia Maurizi, Michael J. Garabedian, Alka Mansukhani, Narendra Verma, Abhilash Gadi, Cristian Coarfa, Eugenia Han, Claudio Basilico
Publikováno v:
Oncotarget
Osteosarcoma (OS) is a highly aggressive pediatric bone cancer in which most tumor cells remain immature and fail to differentiate into bone-forming osteoblasts. However, OS cells readily respond to adipogenic stimuli suggesting they retain mesenchym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e69440c0bd1ca966718c2f420eb477
http://europepmc.org/articles/PMC5308629
http://europepmc.org/articles/PMC5308629
Publikováno v:
Oncogene
The stem cell transcription factor Sox2 is highly expressed in many cancers where it is thought to mark cancer stem cells (CSCs). In osteosarcomas, the most common bone malignancy, high Sox2 expression marks and maintains a fraction of tumor-initiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b00902b8320e9edf555ea2e15d7b4fa
https://pubmed.ncbi.nlm.nih.gov/29743593
https://pubmed.ncbi.nlm.nih.gov/29743593
Autor:
Claudio Basilico, Richard Bonneau, Zeynep Tokcaer-Keskin, Francesco Strino, Zuojian Tang, Stuart M. Brown, Xiangmei Xi, Lisa Dailey, Matthew Murtha, Yuval Kluger, Yatong Wang, Xi Chen
Publikováno v:
Nature methods
Promoters and enhancers establish precise gene transcription patterns. The development of functional approaches for their identification in mammalian cells has been complicated by the size of these genomes. Here we report a new method called FIREWACh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da4b7fec89170312dae9a2b6b4a9dec
https://doi.org/10.1038/nmeth.2885
https://doi.org/10.1038/nmeth.2885
Publikováno v:
Cancer Letters. 338:158-167
Osteosarcoma is an aggressive pediatric tumor of growing bones that, despite surgery and chemotherapy, is prone to relapse. These mesenchymal tumors are derived from progenitor cells in the osteoblast lineage that have accumulated mutations to escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48791d2aca62b03952b8e96e46e73874
https://doi.org/10.1016/j.canlet.2012.05.028
https://doi.org/10.1016/j.canlet.2012.05.028