Výsledky vyhledávání - "Claudio Avila"

Automated stopped-flow library synthesis for rapid optimisation and machine learning directed experimentation

Autor: Claudio Avila, Carlo Cassani, Thierry Kogej, Javier Mazuela, Sunil Sarda, Adam D. Clayton, Michael Kossenjans, Clive P. Green, Richard A. Bourne

Publikováno v: Chemical Science. 13:12087-12099

For the discovery of new candidate molecules in the pharmaceutical industry, library synthesis is a critical step, in which library size, diversity, and time to synthesise are fundamental. In this work we propose stopped-flow synthesis as an intermed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1533c6069f247ef56619a7ca56eb302
https://doi.org/10.1039/d2sc03016k

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Acid number, viscosity and end-point detection in a multiphase high temperature polymerisation process using an online miniaturised MEMS Fabry-Pérot interferometer

Autor: Rodrigo Rocha de Oliveira, Richard A. Bourne, Timothy N. Hunter, Poppy Krassa, Anna de Juan, Anna Rissanen, Claudio Avila, Christos Mantzaridis, Frans L. Muller, Joan Ferré, Uula Kantojärvi

Publikováno v: Avila, C, Mantzaridis, C, Ferré, J, Rocha de Oliveira, R, Kantojärvi, U, Rissanen, A, Krassa, P, de Juan, A, Muller, F L, Hunter, T N & Bourne, R A 2021, ' Acid number, viscosity and end-point detection in a multiphase high temperature polymerisation process using an online miniaturised MEMS Fabry-Pérot interferometer ', Talanta, vol. 224, 121735 . https://doi.org/10.1016/j.talanta.2020.121735

Recent advances in the latest generation of MEMS (micro-electro-mechanical system) Fabry-Pérot interferometers (FPI) for near infrared (NIR) wavelengths has led to the development of ultra-fast and low cost NIR sensors with potential to be used by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74398d12ce4e5e681d591fee8d83430b
https://cris.vtt.fi/en/publications/14f7c536-78dc-4ecd-b718-3f47c2c829fb

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Glycine Receptor Inhibition Differentially Affect Selected Neuronal Populations of the Developing Embryonic Cortex, as Evidenced by the Analysis of Spontaneous Calcium Oscillations

Autor: Denisse Ávila, Ariel Avila, Claudio Avila, Miguel Enrique Sánchez-Hechavarría, Eduardo Aedo

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8013, p 8013 (2020)
Volume 21
Issue 21

The embryonic developing cerebral cortex is characterized by the presence of distinctive cell types such as progenitor pools, immature projection neurons and interneurons. Each of these cell types is diverse on itself, but they all take part of the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95feb725724657da906900828d079276
https://pubmed.ncbi.nlm.nih.gov/33126495

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Process Monitoring of Moisture Content and Mass Transfer Rate in a Fluidised Bed with a Low Cost Inline MEMS NIR Sensor

Autor: Richard A. Bourne, Faiz M. Mahdi, Claudio Avila, Rodrigo Rocha de Oliveira, Joan Ferré, Timothy N. Hunter, Wayne E Sinclair, Anna de Juan, Frans L. Muller, Ali Hassanpour

Publikováno v: Pharmaceutical Research
BASE-Bielefeld Academic Search Engine
Dipòsit Digital de la UB
Universidad de Barcelona

Purpose The current trend for continuous drug product manufacturing requires new, affordable process analytical techniques (PAT) to ensure control of processing. This work evaluates whether property models based on spectral data from recent Fabry–P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19e3276f7c6950ec7dc0c7102050fb3
http://europepmc.org/articles/PMC7174278

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Data fusion strategies to combine sensor and multivariate model outputs for multivariate statistical process control

Autor: Richard A. Bourne, Frans L. Muller, Claudio Avila, Rodrigo Rocha de Oliveira, Anna de Juan

Process analytical technologies (PAT) applied to process monitoring and control generally provide multiple outputs that can come from different sensors or from different model outputs generated from a single multivariate sensor. This paper provides a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fc618a9a5a0f54da046a7c2bd6c940
https://eprints.whiterose.ac.uk/155953/1/ABC-01718-2019_R2.pdf

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'The healthcare system is not designed around my needs': How healthcare consumers self-integrate conventional and complementary healthcare services

Autor: Claudio Avila, Joanne Bradbury, Sandra Grace, A. Du Chesne

Publikováno v: Complementary therapies in clinical practice. 32

Objective To explore healthcare consumers' experiences of healthcare service integration. Methods This phenomenological study comprised three focus groups of 13 participants who were purposively invited to span three broad generations: young adults,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4818025daef84562b576d66c37ba673d
https://pubmed.ncbi.nlm.nih.gov/30057043

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Alisporivir plus ribavirin, interferon free or in combination with pegylated interferon, for hepatitis C virus genotype 2 or 3 infection

Autor: Cheng Yuan Peng, Wan-Long Chuang, Wei Zhang, Jens Rasenack, Nikolai V. Naoumov, Bin Li, Claudio Avila, Shiv Kumar Sarin, Jean-Michel Pawlotsky, Heiner Wedemeyer, Kelly A. Wong, Christophe Hézode, Samir Shah, Robert Flisiak, Graham R. Foster, Teerha Piratvisuth

Publikováno v: Hepatology. 62:1013-1023

Alisporivir is a cyclophilin inhibitor with pan-genotypic anti–hepatitis C virus (HCV) activity and a high barrier to viral resistance. The VITAL-1 study assessed alisporivir as interferon (IFN)-free therapy in treatment-naive patients infected wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f520a6de07f25e42f8cc2b0de99f2cf
https://doi.org/10.1002/hep.27960

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Telbivudine plus pegylated interferon alfa-2a in a randomized study in chronic hepatitis B is associated with an unexpected high rate of peripheral neuropathy

Autor: Mario Rizzetto, Seng Gee Lim, Rifaat Safadi, Nikolai V. Naoumov, Patrick Marcellin, Hugo Fainboim, Cheng Yuan Peng, Heiner Wedemeyer, Aldo Trylesinski, Wan-Long Chuang, Karsten Wursthorn, Michael Manns, Claudio Avila, George K. K. Lau, Graham R. Foster, W. Bao, Edward Gane

Publikováno v: Journal of Hepatology. 62:41-47

This study investigated the antiviral efficacy and safety of telbivudine in combination with pegylated interferon (PegIFN) alpha-2a in chronic hepatitis B (CHB) patients.This was a randomized, open-label, multicentre study, in treatment-naïve patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49fc58088a904eb186196ced4a43673
https://doi.org/10.1016/j.jhep.2014.08.021

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