Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Claudio Mapelli"'
Autor:
Jing Yang, Claudio Mapelli, Zhaoqing Wang, Chi Shing Sum, Ji Hua, R. Michael Lawrence, Yan Ni, Dietmar A. Seiffert
Publikováno v:
Platelets, Vol 33, Iss 7, Pp 979-986 (2022)
Protease-activated receptor 4 (PAR4) is a promising drug target to improve the efficacy/safety window of antiplatelet agents. The native peptide GYPGQV, and the more-potent peptide AYPGKF, are PAR4-specific activators. However, these PAR4 agonist pep
Externí odkaz:
https://doaj.org/article/da63be13adb74a87bc2112cc0441e456
Autor:
Angie Sun, Brian Hall, Jennifer O'Neil, Abbas Walji, Claudio Mapelli, Michael J. Hohn, Mark J Demma
Publikováno v:
FEBS Letters. 594:1467-1476
Myc, a transcription factor with oncogenic activity, is upregulated by amplification, translocation, and mutation of the cellular pathways that regulate its stability. Inhibition of the Myc oncogene by various modalities has had limited success. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bbf5ccd1517becdfa722df7872cc4a
https://doi.org/10.1002/1873-3468.13759
https://doi.org/10.1002/1873-3468.13759
Autor:
Raffeal Bennett, Ian Mangion, Gregory F. Pirrone, Erik L. Regalado, Debopreeti Mukherjee, Alexey A. Makarov, Timothy Nowak, Claudio Mapelli, Jennifer L. Hickey, Vladimir Shchurik
Publikováno v:
Analytica chimica acta. 1142
At the forefront of synthetic endeavors in the pharmaceutical industry, including drug discovery and high-throughput screening, timelines are tight and large quantities of pure chemical targets are rarely available. In this regard, the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5999d2706794a3ac4e4abb59d7f43c4
https://pubmed.ncbi.nlm.nih.gov/33280687
https://pubmed.ncbi.nlm.nih.gov/33280687
Autor:
Nabil G Seidah, Steve Poirier, Maxime Denis, Rex Parker, Bowman Miao, Claudio Mapelli, Annik Prat, Hanny Wassef, Jean Davignon, Katherine A Hajjar, Gaétan Mayer
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41865 (2012)
Proprotein convertase subtilisin/kexin-9 (PCSK9) enhances the degradation of hepatic low-density lipoprotein receptor (LDLR). Deletion of PCSK9, and loss-of-function mutants in humans result in lower levels of circulating LDL-cholesterol and a strong
Externí odkaz:
https://doaj.org/article/01c0adcef4634440bdb84bf935f462b6
Autor:
Michael A. Poss, Jennifer X. Qiao, Xiao-Bing Wang, Jin-Quan Yu, Claudio Mapelli, Qian Shao, Forrest Zhang, Ru-Yi Zhu, Qingfeng Wu, Peng-Xiang Shen, Jian He
Publikováno v:
Science. 355:499-503
Expressed preferences among methyl groups Targeting just one of the two equivalent branch ends in Y-shaped molecules is a particular challenge for catalysis. Enzymes manage to do it by grasping the whole molecule, octopus-like, but often enzymes cann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65468fec4c3c78e3fa9831f9337cfd4f
https://doi.org/10.1126/science.aal5175
https://doi.org/10.1126/science.aal5175
Autor:
Abbas Walji, John Zelina, Federica Orvieto, Smaranda Bodea, Simona Altezza, Derek Wiswell, Mark J Demma, Shiying Chen, Jennifer O'Neil, Enrique Escandón, Eric S. Muise, Alessia Santoprete, Brian Hall, Claudio Mapelli, Benjamin Ruprecht, Angie Sun, Kallol Ray, Federica Tucci, Sarah Javaid
Publikováno v:
Molecular and Cellular Biology
The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription.
The
The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef31b9d6cd632d0e4db013eeb058b278
https://doi.org/10.1128/mcb.00248-19
https://doi.org/10.1128/mcb.00248-19
Autor:
Federica Orvieto, Mark J Demma, Canada Keith A, Alycia V Shoultz, Alessia Santoprete, Kuanchang Chen, Amy Bittner Mccracken, Xiaohong Zhu, Scott A. Johnson, Claudio Mapelli, Iman Farasat, Brian M. Lacey, Zachary Z Brown, Abbas Walji, Robert M. Garbaccio, Jennifer O'Neil, Elisabetta Bianchi
Publikováno v:
The Journal of organic chemistry. 85(3)
The Myc transcription factor represents an "undruggable" target of high biological interest due to its central role in various cancers. An abbreviated form of the c-Myc protein, called Omomyc, consists of the Myc DNA-binding domain and a coiled-coil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbde67858f848c479c02eb0d491b7bd
https://pubmed.ncbi.nlm.nih.gov/31660743
https://pubmed.ncbi.nlm.nih.gov/31660743
Autor:
Jian He, Kap-Sun Yeung, Jin-Quan Yu, Claudio Mapelli, Zhong Jin, Michael A. Poss, Zhipeng Zhang, Suhua Li, Pankaj Jain, Toshihiko Shigenari, Michael M. Miller, Gang Chen, Paul Michael Scola
Publikováno v:
Journal of the American Chemical Society. 137:3338-3351
Pd-catalyzed β-C-H functionalizations of carboxylic acid derivatives using an auxiliary as a directing group have been extensively explored in the past decade. In comparison to the most widely used auxiliaries in asymmetric synthesis, the simplicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7bd4bec96aa06daea0d5d2bc2e473a
https://doi.org/10.1021/ja512690x
https://doi.org/10.1021/ja512690x
Autor:
Claudio Mapelli, Douglas James Riexinger, Kimberly Voronin, Jianing Zeng, Ving G. Lee, Samuel J. Bonacorsi, Sharon Gong, Nishith Sanghvi, Hao Jiang, Alban Allentoff
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:579-583
The synthesis of a 16-residue, stable isotopically labeled peptide is described for use as a LC-MS/MS (Liquid chromatography-mass spectrometry/mass spectrometry) internal standard in bioanalytical studies. This peptide serves as a single universal su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bdf69b55d2a122a2006964d7d78d4d6
https://doi.org/10.1002/jlcr.3218
https://doi.org/10.1002/jlcr.3218
Autor:
Li Xin, Ming Lei, Claudio Mapelli, Tasir Shamsul Haque, Ge Zhang, John Krupinski, Sarah E. Malmstrom, Ving G. Lee, Douglas James Riexinger, Songping Han, William R. Ewing, Cooper Christopher B
Publikováno v:
Peptides. 31:950-955
We report the identification of potent agonists of the Glucagon-Like Peptide-1 Receptor (GLP-1R). These compounds are short, 11 amino acid peptides containing several unnatural amino acids, including (in particular) analogs of homohomophenylalanine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ba8ccad0d57dfbb86122717aef54d4
https://doi.org/10.1016/j.peptides.2010.01.008
https://doi.org/10.1016/j.peptides.2010.01.008