Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

Autor: Margherita Piccardi, Manuel Gentiluomo, Stefania Bertoncini, Raffaele Pezzilli, Bálint Erőss, Stefania Bunduc, Faik G. Uzunoglu, Renata Talar-Wojnarowska, Tomas Vanagas, Cosimo Sperti, Martin Oliverius, Mateus Nóbrega Aoki, Stefano Ermini, Tamás Hussein, Ugo Boggi, Krzysztof Jamroziak, Evaristo Maiello, Luca Morelli, Ludmila Vodickova, Gregorio Di Franco, Stefano Landi, Andrea Szentesi, Martin Lovecek, Marta Puzzono, Francesca Tavano, Hanneke W. M. van Laarhoven, Alessandro Zerbi, Beatrice Mohelnikova-Duchonova, Hannah Stocker, Eithne Costello, Gabriele Capurso, Laura Ginocchi, Rita T. Lawlor, Giuseppe Vanella, Francesca Bazzocchi, Jakob R. Izbicki, Anna Latiano, Bas Bueno-de-Mesquita, Ruggero Ponz de Leon Pisani, Ben Schöttker, Pavel Soucek, Péter Hegyi, Maria Gazouli, Thilo Hackert, Juozas Kupcinskas, Lina Poskiene, Matteo Tacelli, Susanne Roth, Silvia Carrara, Francesco Perri, Viktor Hlavac, George E. Theodoropoulos, Olivier R. Busch, Andrea Mambrini, Casper H. J. van Eijck, Paolo Arcidiacono, Aldo Scarpa, Claudio Pasquali, Daniela Basso, Maurizio Lucchesi, Anna Caterina Milanetto, John P. Neoptolemos, Giulia Martina Cavestro, Dainius Janciauskas, Xuechen Chen, Roger Chammas, Mara Goetz, Hermann Brenner, Livia Archibugi, Michael Dannemann, Federico Canzian, Sergio Tofanelli, Daniele Campa

Publikováno v: Biological Research, Vol 56, Iss 1, Pp 1-9 (2023)

Abstract Background The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Neandertal-introgre

Externí odkaz: https://doaj.org/article/5ff8a3d541ef46499f490cb19c62c412

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Autor: Giuseppe Di Fede, Marcella Catania, Cristiana Atzori, Fabio Moda, Claudio Pasquali, Antonio Indaco, Marina Grisoli, Marta Zuffi, Maria Cristina Guaita, Roberto Testi, Stefano Taraglio, Maria Sessa, Graziano Gusmaroli, Mariacarmela Spinelli, Giulia Salzano, Giuseppe Legname, Roberto Tarletti, Laura Godi, Maurizio Pocchiari, Fabrizio Tagliavini, Daniele Imperiale, Giorgio Giaccone

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)

Abstract Prion diseases are neurodegenerative disorders which are caused by an accumulation of the abnormal, misfolded prion protein known as scrapie prion protein (PrPSc). These disorders are unique as they occur as sporadic, genetic and acquired fo

Externí odkaz: https://doaj.org/article/46afdf2fd23547ffa41d811b6d180715

Genetic and non-genetic risk factors for early-onset pancreatic cancer

Autor: Ylenia Nodari, Manuel Gentiluomo, Beatrice Mohelnikova-Duchonova, Edita Kreivenaite, Anna Caterina Milanetto, Jurgita Skieceviciene, Stefano Landi, Rita T Lawlor, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Martin Lovecek, Maria Gazouli, Maarten F. Bijlsma, Luca Morelli, Vytautas Kiudelis, Matteo Tacelli, Dalila Lucíola Zanette, Pavel Soucek, Faik Uzunoglu, Rudolf Kaaks, Jakob Izbicki, Ugo Boggi, Raffaele Pezzilli, Andrea Mambrini, Claudio Pasquali, Hanneke W. van Laarhoven, Verena Katzke, Giulia Martina Cavestro, Cosimo Sperti, Martin Loos, Anna Latiano, Bálint Erőss, Martin Oliverius, Theron Johnson, Daniela Basso, John P. Neoptolemos, Mateus Nóbrega Aoki, William Greenhalf, Pavel Vodicka, Livia Archibugi, Giuseppe Vanella, Maurizio Lucchesi, Renata Talar-Wojnarowska, Krzysztof Jamroziak, Mohammed Al Saeedi, Casper H.J. van Eijck, Juozas Kupcinskas, Tamás Hussein, Marta Puzzono, Stefania Bunduc, Mara Götz, Silvia Carrara, Andrea Szentesi, Francesca Tavano, Stefania Moz, Péter Hegyi, Claudio Luchini, Gabriele Capurso, Francesco Perri, Stefano Ermini, George Theodoropoulos, Giovanni Capretti, Orazio Palmieri, Laura Ginocchi, Niccolò Furbetta, Federico Canzian, Daniele Campa

Publikováno v: Digestive and Liver Disease. Elsevier
Nodari, Y, Gentiluomo, M, Mohelnikova-Duchonova, B, Kreivenaite, E, Milanetto, A C, Skieceviciene, J, Landi, S, Lawlor, R T, Petrone, M C, Arcidiacono, P G, Lovecek, M, Gazouli, M, Bijlsma, M F, Morelli, L, Kiudelis, V, Tacelli, M, Zanette, D L, Soucek, P, Uzunoglu, F, Kaaks, R, Izbicki, J, Boggi, U, Pezzilli, R, Mambrini, A, Pasquali, C, van Laarhoven, H W, Katzke, V, Cavestro, G M, Sperti, C, Loos, M, Latiano, A, Erőss, B L, Oliverius, M, Johnson, T, Basso, D, Neoptolemos, J P, Aoki, M N B, Greenhalf, W, Vodicka, P, Archibugi, L, Vanella, G, Lucchesi, M, Talar-Wojnarowska, R, Jamroziak, K, Saeedi, M A, van Eijck, C H J, Kupcinskas, J, Hussein, T, Puzzono, M, Bunduc, S, Götz, M, Carrara, S, Szentesi, A, Tavano, F, Moz, S, Hegyi, P T, Luchini, C, Capurso, G, Perri, F, Ermini, S, Theodoropoulos, G, Capretti, G, Palmieri, O, Ginocchi, L, Furbetta, N, Canzian, F & Campa, D 2023, ' Genetic and non-genetic risk factors for early-onset pancreatic cancer ', Digestive and Liver Disease . https://doi.org/10.1016/j.dld.2023.02.023
Digestive and liver disease. Elsevier

Background: Early-onset pancreatic cancer (EOPC) represents 5–10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908b302f31600ad0c324d0be7a47532d
https://pure.eur.nl/en/publications/a96c0fc0-eb08-405f-bf2a-f59d50640a72

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer

Autor: Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nóbrega Aoki, Martin Oliverius, Ludmila Vodičková, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamás Hussein, Beatrice Mohelnikova-Duchonova, Casper H.J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Pérez, Martin Lovecek, Markus W. Büchler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Götz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schöttker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Péter Hegyi, Luca Morelli, Niccolò Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederike Dijk, Anna Caterina Milanetto, Francesca Tavano, Klara Cervena, Bálint Erőss, Sabrina G. Testoni, Judith H.E. Verhagen-Oldenampsen, Ewa Małecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian

Publikováno v: Critical reviews in oncology/hematology
Campa, D, Gentiluomo, M, Stein, A, Aoki, M N B, Oliverius, M, Vodičková, L, Jamroziak, K, Theodoropoulos, G, Pasquali, C, Greenhalf, W, Arcidiacono, P G, Uzunoglu, F, Pezzilli, R, Luchini, C, Puzzono, M, Loos, M, Giaccherini, M, Katzke, V, Mambrini, A, Kiudeliene, E, Federico, K E, Johansen, J, Hussein, T, Mohelnikova-Duchonova, B, van Eijck, C H J, Brenner, H, Farinella, R, Pérez, J S, Lovecek, M, Büchler, M W, Hlavac, V, Izbicki, J R, Hackert, T, Chammas, R, Zerbi, A, Lawlor, R, Felici, A, Götz, M, Capurso, G, Ginocchi, L, Gazouli, M, Kupcinskas, J, Cavestro, G M, Vodicka, P, Moz, S, Neoptolemos, J P, Kunovsky, L, Bojesen, S E, Carrara, S, Gioffreda, D, Morkunas, E, Abian, O, Bunduc, S, Basso, D, Boggi, U, Wlodarczyk, B, Szentesi, A, Vanella, G, Chen, I, Bijlsma, M F, Kiudelis, V, Landi, S, Schöttker, B, Corradi, C, Giese, N, Kaaks, R, Peduzzi, G, Hegyi, P T, Morelli, L, Furbetta, N, Soucek, P, Latiano, A, Talar-Wojnarowska, R, Lindgaard, S C, Dijk, F, Milanetto, A C, Tavano, F, Cervena, K, Erőss, B L, Testoni, S G, Verhagen-Oldenampsen, J H E, Małecka-Wojciesko, E, Costello, E, Salvia, R, Maiello, E, Ermini, S, Sperti, C, Holleczek, B, Perri, F, Skieceviciene, J, Archibugi, L, Lucchesi, M, Rizzato, C & Canzian, F 2023, ' The PANcreatic Disease ReseArch (PANDoRA) consortium : Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer ', Critical Reviews in Oncology/Hematology, vol. 186, 104020 . https://doi.org/10.1016/j.critrevonc.2023.104020

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e2b865a80bd50161d13cfdbcf249c7
https://is.muni.cz/publication/2297219

Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Autor: Chiara Corradi, Giulia Lencioni, Manuel Gentiluomo, Alessio Felici, Anna Latiano, Gediminas Kiudelis, Casper H J van Eijck, Katalin Marta, Rita T Lawlor, Francesca Tavano, Ugo Boggi, Frederike Dijk, Giulia Martina Cavestro, Roel C H Vermeulen, Thilo Hackert, Maria Chiara Petrone, Faik Güntac Uzunoğlu, Livia Archibugi, Jakob R Izbicki, Luca Morelli, Alessandro Zerbi, Stefano Landi, Hannah Stocker, Renata Talar-Wojnarowska, Gregorio Di Franco, Péter Hegyi, Cosimo Sperti, Silvia Carrara, Gabriele Capurso, Maria Gazouli, Hermann Brenner, Stefania Bunduc, Olivier Busch, Francesco Perri, Martin Oliverius, Péter Jeno Hegyi, Mara Goetz, Pasquale Scognamiglio, Andrea Mambrini, Paolo Giorgio Arcidiacono, Edita Kreivenaite, Juozas Kupcinskas, Tamas Hussein, Stefano Ermini, Anna Caterina Milanetto, Pavel Vodicka, Vytautas Kiudelis, Viktor Hlaváč, Pavel Soucek, George E Theodoropoulos, Daniela Basso, John P Neoptolemos, Mateus Nóbrega Aoki, Raffaele Pezzilli, Claudio Pasquali, Roger Chammas, Sabrina Gloria Giulia Testoni, Beatrice Mohelnikova-Duchonova, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian, Daniele Campa

Publikováno v: Journal of Medical Genetics. BMJ Publishing Group
Journal of medical genetics. BMJ Publishing Group
Corradi, C, Lencioni, G, Gentiluomo, M, Felici, A, Latiano, A, Kiudelis, G, van Eijck, C H J, Marta, K, Lawlor, R T, Tavano, F, Boggi, U, Dijk, F, Cavestro, G M, Vermeulen, R C H, Hackert, T, Petrone, M C, Uzunoğ lu, F G N, Archibugi, L, Izbicki, J R, Morelli, L, Zerbi, A, Landi, S, Stocker, H, Talar-Wojnarowska, R, di Franco, G, Hegyi, P T, Sperti, C, Carrara, S, Capurso, G, Gazouli, M, Brenner, H, Bunduc, S, Busch, O, Perri, F, Oliverius, M, Hegyi, P T J, Goetz, M, Scognamiglio, P, Mambrini, A, Arcidiacono, P G, Kreivenaite, E, Kupcinskas, J, Hussein, T, Ermini, S, Milanetto, A C, Vodicka, P, Kiudelis, V, Hlaváč, V, Soucek, P, Theodoropoulos, G E, Basso, D, Neoptolemos, J P, Nóbrega Aoki, M, Pezzilli, R, Pasquali, C, Chammas, R, Testoni, S G G, Mohelnikova-Duchonova, B, Lucchesi, M, Rizzato, C, Canzian, F & Campa, D 2023, ' Polymorphic variants involved in methylation regulation : a strategy to discover risk loci for pancreatic ductal adenocarcinoma ', Journal of Medical Genetics . https://doi.org/10.1136/jmg-2022-108910

IntroductionOnly a small number of risk factors for pancreatic ductal adenocarcinoma (PDAC) has been established. Several studies identified a role of epigenetics and of deregulation of DNA methylation. DNA methylation is variable across a lifetime a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7e994d0576232b00fd676671fa0272
https://doi.org/10.1136/jmg-2022-108910