Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Autor: Fanny Baran-Marszak, Mohand Boukhiar, Stéphanie Harel, Christelle Laguillier, Claudine Roger, Remy Gressin, Antoine Martin, Remi Fagard, Nadine Varin-Blank, Florence Ajchenbaum-Cymbalista, Dominique Ledoux

Publikováno v: Haematologica, Vol 95, Iss 11 (2010)

Background The deregulation of several transcription factors contribute to the aggressive course of mantle cell lymphoma. This study focuses on survival signals emanating from the tumor environment and involving the signal transducer and activator of

Externí odkaz: https://doaj.org/article/eeb2cfaccdfe4fb1b931f89a48218a57

Survival Response to B-Cell Receptor Ligation Is Restricted to Progressive Chronic Lymphocytic Leukemia Cells Irrespective of Zap70 Expression

Autor: Claudine Roger, Nathalie Chevallier, Rémi Letestu, Celia Salanoubat, Florence Ajchenbaum-Cymbalista, Laurence Sanhes, Joelle Nataf, Pierre-Antoine Deglesne, Taoufik Beitar, Fanny Baran-Marszak, Nadine Varin-Blank

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2006, 66 (14), pp.7158-7166. ⟨10.1158/0008-5472.CAN-06-0085⟩

Despite very similar gene expression profiles, the clinical course of B-cell chronic lymphocytic leukemia (B-CLL) is heterogeneous. Immunoglobulin VH (IgVH) mutational status and expression of B-cell receptor (BCR) signaling mediators have been assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedcedcf8c5e0985dc8fac75b74e47ad
https://doi.org/10.1158/0008-5472.can-06-0085

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

Autor: Laura Velazquez, Sylvie Chevret, E. Mazoyer, Anabell Alvarado, Marie-Caroline Le Bousse-Kerdilès, Christophe Desterke, Jean-Jacques Kiladjian, Fanny Baran-Marszak, Bruno Cassinat, Stéphane Giraudier, Hajer Magdoud, Claudine Roger, Nadine Varin-Blank, Carole Tonetti, Florence Cymbalista, Stephanie Harel, Pierre Fenaux

Publikováno v: Blood. 116(26)

Activating mutations in signaling molecules, such as JAK2-V617F, have been associated with myeloproliferative neoplasms (MPNs). Mice lacking the inhibitory adaptor protein Lnk display deregulation of thrombopoietin/thrombopoietin receptor signaling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25a6b43590b85677d0490e4607a8745
https://pubmed.ncbi.nlm.nih.gov/20870899

A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB

Autor: Denis Lesage, Pierre Olivier Schischmanoff, Nadine Varin-Blank, Isabelle Dusanter-Fourt, Valeri Metelev, Inès Souissi, An Cao, Fanny Baran-Marszak, Laurent Ah-Koon, Stéphanie Le Coquil, Imen Najjar, Remi Fagard, Claudine Roger

Publikováno v: BMC Cell Biology
BMC Cell Biology, Vol 12, Iss 1, p 14 (2011)
BMC Cell Biology, BioMed Central, 2011, 12 (1), pp.14. 〈10.1186/1471-2121-12-14〉
BMC Cell Biology, BioMed Central, 2011, 12 (1), pp.14. ⟨10.1186/1471-2121-12-14⟩
BMC Cell Biology, 2011, 12 (1), pp.14. ⟨10.1186/1471-2121-12-14⟩

Background The transcription factor STAT3 (signal transducer and activator of transcription 3) is frequently activated in tumor cells. Activated STAT3 forms homodimers, or heterodimers with other TFs such as NF-κB, which becomes activated. Cytoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bdf102f48c8c7043bef930bf549c54
http://europepmc.org/articles/PMC3082224

Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma

Autor: Julie Tran, Nadine Varin-Blank, Dominique Ledoux, Claudine Roger, Florence Ajchenbaum-Cymbalista, Mohand-Akli Boukhiar, Fanny Baran-Marszak, Antoine Martin, Remy Gressin

Publikováno v: Experimental Hematology & Oncology
Experimental Hematology & Oncology, BMC, 2013, 2 (1), pp.4. ⟨10.1186/2162-3619-2-4⟩
Experimental Hematology & Oncology, Vol 2, Iss 1, p 4 (2013)

Background We previously showed that B-cell receptor (BCR) signaling pathways are important for in vitro survival of mantle cell lymphoma (MCL) cells. To further identify early BCR-activated signaling pathways involved in MCL cell survival, we focuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d7701e8a380329e5e92444892d4806