Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Claudine Dupuis-Hamelin"'
Autor:
Valérie Steier, Catherine Seys, Maxime Lampilas, Claudine Dupuis-Hamelin, Carole Delachaume, Michele Guitton, Thérèse Stachyra, Alain Bonnefoy, Monique Fairley
Publikováno v:
Journal of Antimicrobial Chemotherapy. 54:410-417
OBJECTIVES Production of beta-lactamases is the main mechanism of beta-lactam resistance in Gram-negative bacteria. Despite the current use of clavulanic acid, sulbactam and tazobactam, the prevalence of class A and class C enzymes is increasing worl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b4059cab97926e6d8314f4bc869e49
https://doi.org/10.1093/jac/dkh358
https://doi.org/10.1093/jac/dkh358
Autor:
Claudine Dupuis-Hamelin, Patrick Laurin, Periers Anne-Marie, Patrice Lassaigne, Branislav Musicki, Alain Bonnefoy, Michel Klich, Laurent Piombo
Publikováno v:
Tetrahedron Letters. 44:9259-9262
The design, synthesis, and biological activity in vitro of modified coumarin inhibitors of gyrase B are presented. Noviose, the sugar portion of coumarin antibiotics, was replaced by simplified mimics, a 5′,5′-dimethylcyclohexane or piperidine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1bbde1b9869d1e16befca3ffb510d4c
https://doi.org/10.1016/j.tetlet.2003.10.076
https://doi.org/10.1016/j.tetlet.2003.10.076
Autor:
Patrick Laurin, Pascale Mauvais, Alain Bonnefoy, Michel Klich, Patrice Lassaigne, Claudine Dupuis-Hamelin, Branislav Musicki, Christophe Peixoto
Publikováno v:
Tetrahedron Letters. 41:1741-1745
The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3061360d1ba9cf6259ea4012083b9848
https://doi.org/10.1016/s0040-4039(00)00044-7
https://doi.org/10.1016/s0040-4039(00)00044-7
Autor:
Periers Anne-Marie, Alain Bonnefoy, Didier Ferroud, Michel Klich, Patrice Lassaigne, Pascale Mauvais, Branislav Musicki, Jean-Luc Haesslein, Patrick Laurin, Claudine Dupuis-Hamelin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:161-165
The synthesis and biological profile in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3' of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7759aba47e7200be6016886f62b04427
https://doi.org/10.1016/s0960-894x(99)00654-x
https://doi.org/10.1016/s0960-894x(99)00654-x
Autor:
Michel Klich, Claudine Dupuis-Hamelin, Jeannine Collard, Patrice Lassaigne, Pascale Mauvais, Didier Ferroud, Alain Bonnefoy, Branislav Musicki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2881-2886
A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6d231e9b554c2dc069f0da68c586cf
https://doi.org/10.1016/s0960-894x(99)00493-x
https://doi.org/10.1016/s0960-894x(99)00493-x
Autor:
Alain Bonnefoy, Pascale Mauvais, Laurent Schio, Claudine Dupuis-Hamelin, Patrick Laurin, Michael Klich, Didier Ferroud, Patrice Lassaigne, Branislav Musicki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2875-2880
Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8317ecf0f78a79b58fec6c034c268203
https://doi.org/10.1016/s0960-894x(99)00492-8
https://doi.org/10.1016/s0960-894x(99)00492-8
Autor:
Pascale Mauvais, Didier Ferroud, Alain Bonnefoy, Patrice Lassaigne, Michel Klich, Branislav Musicki, Claudine Dupuis-Hamelin, Patrick Laurin
Publikováno v:
ChemInform. 30
The design, synthesis, and in vitro biological activity of a series of novel coumarin inhibitors of gyrase B is presented. Replacement of the 3-acylamino residue (3-NHCOR) of coumarin drugs with reversed isosteres C(=O)R, C(=N-OR)R', COOR, CONHR and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a749e5802e55302ecc6f9d527999646b
https://doi.org/10.1002/chin.199944288
https://doi.org/10.1002/chin.199944288
Autor:
Michel Klich, Pascale Mauvais, Alain Bonnefoy, Branislav Musicki, Didier Ferroud, Claudine Dupuis-Hamelin, Patrice Lassaigne, Jeannine Collard
Publikováno v:
ChemInform. 31
A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71bbc622902f7dadd832b46af3fdf4b
https://doi.org/10.1002/chin.200006212
https://doi.org/10.1002/chin.200006212
Autor:
Alain Bonnefoy, Didier Ferroud, Pascale Mauvais, Michael Klich, Patrick Laurin, Laurent Schio, Branislav Musicki, Claudine Dupuis-Hamelin, Patrice Lassaigne
Publikováno v:
ChemInform. 31
Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23ac26564abc3cea1345e47d5fa5b88
https://doi.org/10.1002/chin.200007210
https://doi.org/10.1002/chin.200007210
Autor:
Periers Anne-Marie, Didier Ferroud, Pascale Mauvais, Branislav Musicki, Jean-Luc Haesslein, Michel Klich, Patrice Lassaigne, Alain Bonnefoy, Claudine Dupuis-Hamelin, Patrick Laurin
Publikováno v:
ChemInform. 31
The synthesis and biological profile in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3' of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba45abcd17b4442b25eb83db84ff6470
https://doi.org/10.1002/chin.200021226
https://doi.org/10.1002/chin.200021226