Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Claudine Bisson"'
Autor:
Jason S. Wilson, Alicia M. Churchill-Angus, Simon P. Davies, Svetlana E. Sedelnikova, Svetomir B. Tzokov, John B. Rafferty, Per A. Bullough, Claudine Bisson, Patrick J. Baker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pore forming toxins (PFTs) form the major group of virulence factors in many pathogenic bacteria. Here the authors identify tripartite α-helical PFTs in pathogenic Gram negative bacteria and structurally characterize AhlABC from Aeromonas hydrophila
Externí odkaz:
https://doaj.org/article/2f6b67a180744391895b4f4a9d6daa29
Autor:
Abigail J. Perrin, Claudine Bisson, Peter A. Faull, Matthew J. Renshaw, Rebecca A. Lees, Roland A. Fleck, Helen R. Saibil, Ambrosius P. Snijders, David A. Baker, Michael J. Blackman
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Malaria is a deadly infectious disease. Rationally designed novel therapeutics will be essential for its control and eradication.
Externí odkaz:
https://doaj.org/article/6ee9607081a545d7b55c84aede269aec
Autor:
Claudine Bisson, Nathan B. P. Adams, Ben Stevenson, Amanda A. Brindley, Despo Polyviou, Thomas S. Bibby, Patrick J. Baker, C. Neil Hunter, Andrew Hitchcock
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Some bacteria can use inorganic phosphite and hypophosphite as sources of inorganic phosphorus. Here, the authors report crystal structures of the periplasmic proteins that bind these reduced phosphorus species and show that a P-H…π interaction be
Externí odkaz:
https://doaj.org/article/fb628c898a23417e81de94e06a980504
Autor:
Avnish Patel, Abigail J Perrin, Helen R Flynn, Claudine Bisson, Chrislaine Withers-Martinez, Moritz Treeck, Christian Flueck, Giuseppe Nicastro, Stephen R Martin, Andres Ramos, Tim W Gilberger, Ambrosius P Snijders, Michael J Blackman, David A Baker
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000264 (2019)
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disr
Externí odkaz:
https://doaj.org/article/2be28e1039ea4a58a0e34dc0e05e7111
Autor:
Christopher A Rice, Sara J Campbell, Claudine Bisson, Hayley J Owen, Svetlana E Sedelnikova, Patrick J Baker, David W Rice, Fiona L Henriquez, Craig W Roberts
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0198827 (2018)
Acanthamoeba is normally free-living, but sometimes facultative and occasionally opportunistic parasites. Current therapies are, by necessity, arduous and yet poorly effective due to their inabilities to kill cyst stages or in some cases to actually
Externí odkaz:
https://doaj.org/article/85ba507fe704463a900bf5c142dcff83
Autor:
Hugo Belda, Moritz Treeck, Benoit Gamain, Viola Introini, Claudine Bisson, Malgorzata Broncel, Heledd Davies, Marta Tibúrcio, Dominique Dorin-Semblat, Jean-Philippe Semblat, Xingda Ye, Myrsini Kaforou
Publikováno v:
Nature microbiology
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2020, 5 (6), pp.848-863. ⟨10.1038/s41564-020-0702-4⟩
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2020, 5 (6), pp.848-863. ⟨10.1038/s41564-020-0702-4⟩
Summary The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is closely linked to the increase in rigidity of infected erythrocytes and their adhesion to endothelial receptors, obstructing blood flow to vital organs
Publikováno v:
Journal of Visualized Experiments.
Presented here is a protocol for preparing cryo-lamellae from plunge-frozen grids of Plasmodium falciparum-infected human erythrocytes, which could easily be adapted for other biological samples. The basic principles for preparing samples, milling, a
Autor:
Elina Lidumniece, Michael J. Blackman, Konstantinos Koussis, Christine R. Collins, Aigars Jirgensons, Chrislaine Withers-Martinez, Abigail J. Perrin, Claudine Bisson, Fiona Hackett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Malaria remains a major global health threat. In the face of increasing resistance to available chemotherapeutics, new antimalarial drugs with new modes of action are urgently needed. The causative agent of malaria is a single-celled par
Autor:
Tsuyoshi Imasaki, Patrick Baumann, Claudine Bisson, Ashish Radadiya, Yuichiro Takagi, David W. Rice, Svetlana E. Sedelnikova, Nigel G. J. Richards, Adriana Coricello, Tyzoon K. Nomanbhoy, Alexandria H. Berry, Sabine Wenzel, John W. Kozarich, Yi Jin, Brian E. Nordin, Wen Zhu, Francisco Martínez-Márquez
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Communications Biology
Communications Biology
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a bona fide drug
Autor:
Nathan B P, Adams, Claudine, Bisson, Amanda A, Brindley, David A, Farmer, Paul A, Davison, James D, Reid, C Neil, Hunter
Publikováno v:
Nature plants. 6(12)
The insertion of magnesium into protoporphyrin initiates the biosynthesis of chlorophyll, the pigment that underpins photosynthesis. This reaction, catalysed by the magnesium chelatase complex, couples ATP hydrolysis by a ChlID motor complex to chela