Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Claudie Gabillard-Lefort"'
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103393- (2024)
The role of mitochondria spans from the regulation of the oxidative phosphorylation, cell metabolism and survival/death pathways to a more recently identified function in chronic inflammation. In stress situations, mitochondria release some pro-infla
Externí odkaz:
https://doaj.org/article/8cfb507396fd4c07abe288df778e4365
Autor:
Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of
Externí odkaz:
https://doaj.org/article/af089efb2deb4f1abed964d43721db1d
Autor:
Claudie Gabillard-Lefort, Michelle Casey, Arlene M. A. Glasgow, Fiona Boland, Orla Kerr, Elaine Marron, Anne-Marie Lyons, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 205:783-794
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1c75fc17cf33b1bb5eeb96762dd28b
https://doi.org/10.1164/rccm.202106-1426oc
https://doi.org/10.1164/rccm.202106-1426oc
Autor:
Michelle Casey, Claudie Gabillard-Lefort, Oisín F McElvaney, Oliver J McElvaney, Tomás Carroll, Ronan C Heeney, Cedric Gunaratnam, Emer P Reeves, Mark P Murphy, Noel G McElvaney
Publikováno v:
Thorax. :thorax-2022
Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) has been shown to improve lung function in people with cystic fibrosis (PWCF). However, its biological effects remain incompletely understood. Here we describe alterations in pulmonary and systemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b442e6df043caaddb162bbb1a6fbd8c0
https://doi.org/10.1136/thorax-2022-219943
https://doi.org/10.1136/thorax-2022-219943
Autor:
Vipatsorn Shutchaidat, Michael Henry, Bader Alfawaz, Claudie Gabillard-Lefort, Mark E Murphy, Noel G. McElvaney, Padraig Hawkins, Paula Meleady, Thomas McEnery, Orla Coleman, Emer P. Reeves, David A. Bergin
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research
article-version (VoR) Version of Record
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c12b221e483cf6a075ab8311f17278
http://openres.ersjournals.com/content/7/4/00234-2021.full
http://openres.ersjournals.com/content/7/4/00234-2021.full
Autor:
Michael Williamson, Yu Qing Jolene Teo, Noel G. McElvaney, Aram Alharbi, Emer P. Reeves, Claudie Gabillard-Lefort, Michelle Casey
Publikováno v:
Expert review of respiratory medicine. 16(1)
Introduction Cystic fibrosis (CF) is a genetically inherited disease, with mortality and morbidity associated with respiratory disease. The inflammatory response in CF is characterized by excessive neutrophil influx to the airways, mainly due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4592b62c6844c880a893ae6f3339b2
https://pubmed.ncbi.nlm.nih.gov/34726115
https://pubmed.ncbi.nlm.nih.gov/34726115
Autor:
Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard-Lefort, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney
Publikováno v:
EBioMedicine. 77
Background Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the protease-anti-protease balance in the circulation and pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c191dfe15f2bd153e567baf2798ce8ea
https://pubmed.ncbi.nlm.nih.gov/35217407
https://pubmed.ncbi.nlm.nih.gov/35217407
Autor:
Michael E. O’Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
International Journal of Molecular Sciences. 23:2441
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its anti-inflammatory activities mediated by a broad spectrum of protein, cytokine, and cell surfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c3272317f6677cb84233639f5927a7
https://doi.org/10.3390/ijms23052441
https://doi.org/10.3390/ijms23052441
Autor:
Stéphanie Chadet, Marie Piollet, Claudie Gabillard-Lefort, Fabrice Ivanes, Oana-Maria Aburel, Lauriane Benoist, Denis Angoulvant, Danina-Mirela Muntean, Adrian Sturza
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 855, p 855 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences
Volume 22
Issue 2
Vascular dysfunction in cardiovascular diseases includes vasomotor response impairments, endothelial cells (ECs) activation, and smooth muscle cells (SMCs) proliferation and migration to the intima. This results in intimal hyperplasia and vessel fail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc7f49014c876a048c909645896ddfc
https://doi.org/10.3390/ijms22020855
https://doi.org/10.3390/ijms22020855