Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Claudie Gabillard"'
Autor:
Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103894- (2022)
Summary: Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the protease-anti-protease balance in the circulation and
Externí odkaz:
https://doaj.org/article/8689f1b6c49645dc94c1c385411f7c38
Autor:
Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of
Externí odkaz:
https://doaj.org/article/af089efb2deb4f1abed964d43721db1d
Autor:
Michael E. O’Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2441 (2022)
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its anti-inflammatory activities mediated by a broad spectrum of protein, cytokine, and cell surfac
Externí odkaz:
https://doaj.org/article/e95866bc15ba4f818cf757bd848d6ef5
Autor:
Marie Piollet, Adrian Sturza, Stéphanie Chadet, Claudie Gabillard-Lefort, Lauriane Benoist, Danina-Mirela Muntean, Oana-Maria Aburel, Denis Angoulvant, Fabrice Ivanes
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 855 (2021)
Vascular dysfunction in cardiovascular diseases includes vasomotor response impairments, endothelial cells (ECs) activation, and smooth muscle cells (SMCs) proliferation and migration to the intima. This results in intimal hyperplasia and vessel fail
Externí odkaz:
https://doaj.org/article/45a782d0e7674acea390fb0de2349229
Autor:
Claudie Gabillard-Lefort, Michelle Casey, Arlene M. A. Glasgow, Fiona Boland, Orla Kerr, Elaine Marron, Anne-Marie Lyons, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 205:783-794
Autor:
Casey, Michelle, Lefort, Claudie Gabillard, McElvaney, Oisín F., McElvaney, Oliver J., Carroll, Tomás, Heeney, Ronan C., Gunaratnam, Cedric, Reeves, Emer P., Murphy, Mark P., McElvaney, Noel G.
Publikováno v:
Thorax; Aug2023, Vol. 78 Issue 8, p835-839, 5p
Autor:
Michelle Casey, Claudie Gabillard-Lefort, Oisín F McElvaney, Oliver J McElvaney, Tomás Carroll, Ronan C Heeney, Cedric Gunaratnam, Emer P Reeves, Mark P Murphy, Noel G McElvaney
Publikováno v:
Thorax. :thorax-2022
Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) has been shown to improve lung function in people with cystic fibrosis (PWCF). However, its biological effects remain incompletely understood. Here we describe alterations in pulmonary and systemi
Autor:
Vipatsorn Shutchaidat, Michael Henry, Bader Alfawaz, Claudie Gabillard-Lefort, Mark E Murphy, Noel G. McElvaney, Padraig Hawkins, Paula Meleady, Thomas McEnery, Orla Coleman, Emer P. Reeves, David A. Bergin
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research
article-version (VoR) Version of Record
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of
Autor:
Michael Williamson, Yu Qing Jolene Teo, Noel G. McElvaney, Aram Alharbi, Emer P. Reeves, Claudie Gabillard-Lefort, Michelle Casey
Publikováno v:
Expert review of respiratory medicine. 16(1)
Introduction Cystic fibrosis (CF) is a genetically inherited disease, with mortality and morbidity associated with respiratory disease. The inflammatory response in CF is characterized by excessive neutrophil influx to the airways, mainly due to the
Autor:
Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard-Lefort, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney
Publikováno v:
EBioMedicine. 77
Background Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the protease-anti-protease balance in the circulation and pulmonary