Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Claudia Zampaloni"'
Autor:
Caterina Bissantz, Claudia Zampaloni, Pascale David-Pierson, Guennaelle Dieppois, Andreas Guenther, Andrej Trauner, Lotte Winther, William Stubbings
Publikováno v:
Antibiotics, Vol 13, Iss 1, p 72 (2024)
Antibiotic development traditionally involved large Phase 3 programs, preceded by Phase 2 studies. Recognizing the high unmet medical need for new antibiotics and, in some cases, challenges to conducting large clinical trials, regulators created a st
Externí odkaz:
https://doaj.org/article/8b350f65cd544b579d8799292ca67984
Autor:
Matthew F. Kaleta, Olga E. Petrova, Claudia Zampaloni, Fernando Garcia-Alcalde, Matthew Parker, Karin Sauer
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Transcriptomic studies have revealed a large number of uncharacterized genes that are differentially expressed in biofilms, which may be important in regulating biofilm phenotypes such as resistance to antimicrobial agents. To identify biofi
Externí odkaz:
https://doaj.org/article/e446955beeea4e8faa141ae2c3ef3b3d
Autor:
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare mu
Externí odkaz:
https://doaj.org/article/e3d8b35e0db44a9784cca19e12812b34
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1891 (2008)
Increased tolerance to antimicrobial agents is thought to be an important feature of microbes growing in biofilms. We address the question of how biofilm organization affects antibiotic susceptibility. We established Escherichia coli biofilms with di
Externí odkaz:
https://doaj.org/article/1d62c341158f431fbc6a6a50eb630616
Autor:
Michael H. Baym, Claudia Zampaloni, Roy Kishony, Andreas Haldimann, Fabian Glaser, Idan Yelin, Dor Russ, Eric D. Kelsic, Einat Shaer Tamar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Beta-lactamase inhibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactamase enzymes. These inhibitors compete with the beta-lactam antibiotic for the same binding site on the beta-lactamase, thus generating an evolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0d9aff47b7d0289c60b3d57610c7c3
https://doaj.org/article/e3d8b35e0db44a9784cca19e12812b34
https://doaj.org/article/e3d8b35e0db44a9784cca19e12812b34
Autor:
Claudia Zampaloni, Rusudan Okujava, Isabelle Walter, Caterina Bissantz, Elisabet I. Nielsen, Tianlai Shi, Andreas Haldimann, Anders N. Kristoffersson
Publikováno v:
Journal of Antimicrobial Chemotherapy.
Background Diazabicyclooctanes (DBOs) are an increasingly important group of non β-lactam β-lactamase inhibitors, employed clinically in combinations such as ceftazidime/avibactam. The dose finding of such combinations is complicated using the trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efa4db951fbe72593dff9f89291a35e
https://doi.org/10.1093/jac/dkz440
https://doi.org/10.1093/jac/dkz440
Autor:
Fabian Glaser, Claudia Zampaloni, Einat Shaer Tamar, Dor Russ, Roy Kishony, Idan Yelin, Andreas Haldimann
Beta-lactamase inhibitors are increasingly used to counteract microbial resistance to beta-lactam antibiotics mediated by beta-lactamase enzymes. These inhibitors compete with the beta-lactam drug for the same binding site of the beta-lactamase, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1bc61245061dc309d77fb869d0ed3d
Autor:
Claudia Zampaloni, Tomefa E. Asempa, Kamilia Abdelraouf, Caterina Bissantz, David P. Nicolau, Ana Motos
Nacubactam is a novel, broad-spectrum, β-lactamase inhibitor that is currently under development as combination therapy with meropenem. This study evaluated the efficacy of human-simulated epithelial lining fluid (ELF) exposures of meropenem, nacuba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd90e7202c593a886edcd0e8116d45c
https://europepmc.org/articles/PMC6437545/
https://europepmc.org/articles/PMC6437545/
Autor:
Caterina Bissantz, Sara Giovagnoli, Marguerite L. Monogue, David P. Nicolau, Claudia Zampaloni
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Urinary tract infections (UTIs) are a tremendous burden on the health care system due to the vast number of infections resulting in antibiotic therapy and/or hospitalization. Additionally, these infections are frequently caused by multidrug-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad856153e0b660561e3c733bb25fa19
https://doi.org/10.1128/aac.02596-17
https://doi.org/10.1128/aac.02596-17
Publikováno v:
Scientific Reports
Global transcriptomic analysis via RNA-seq is often hampered by the high abundance of ribosomal (r)RNA in bacterial cells. To remove rRNA and enrich coding sequences, subtractive hybridization procedures have become the approach of choice prior to RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408deab1a81f0619adea4bf07efd67cf
https://pubmed.ncbi.nlm.nih.gov/28117413
https://pubmed.ncbi.nlm.nih.gov/28117413