Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Claudia Wrzos"'
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Akademický článek
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Autor: Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons
Publikováno v: Cell Reports, Vol 16, Iss 2, Pp 314-322 (2016)
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target mye
Externí odkaz: https://doaj.org/article/e689c7d8c7524e5585884a9cb5ab5c4d
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2
Microglia damage precedes major myelin breakdown in X‐linked adrenoleukodystrophy and metachromatic leukodystrophy
Autor: Gisela Stoltenburg-Didinger, Dirk Fitzner, Stefan Nessler, Christian Hartmann, Caroline G. Bergner, Anne Winkler, Franziska van der Meer, Claudia Wrzos, Christine Stadelmann, Emil Valizada, Simon Hametner, Mevlude Türkmen, Wolfgang Brück, Sabine Pfeifenbring
Publikováno v: Glia
X‐linked adrenoleukodystrophy (X‐ALD) and metachromatic leukodystrophy (MLD) are two relatively common examples of hereditary demyelinating diseases caused by a dysfunction of peroxisomal or lysosomal lipid degradation. In both conditions, accumu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2768b1fc357db3ee77acb5bc8a52e34f
http://europepmc.org/articles/PMC6594046
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3
Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration
Autor: Mayland Chang, Claudia Wrzos, Dietmar Rudolf Thal, Ming Gao, Anne Winkler, Michael Haberl, Jeffrey Bennett, Christine Stadelmann, Ghislain Opdenakker, Wiebke Möbius, Stefan Nessler, Marie-Theres Weil, Francesca Odoardi
Publikováno v: J Clin Invest
Approximately 80% of neuromyelitis optica spectrum disorder (NMOSD) patients harbor serum anti-aquaporin-4 autoantibodies targeting astrocytes in the CNS. Crucial for NMOSD lesion initiation is disruption of the blood-brain barrier (BBB), which allow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3c02a462a19c012e04ea86da0d3c2b
https://doi.org/10.1172/jci141694
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4
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Autor: Nicole Schaeren-Wiemers, Marie-Theres Weil, Jeffrey Bennett, Anne Winkler, Martin Kerschensteiner, Mikael Simons, Torben Ruhwedel, Christine Stadelmann, Elisa Romanelli, Lukas Enz, Claudia Wrzos, Klaus-Armin Nave, Norbert Goebels, Wiebke Möbius
Publikováno v: Cell Reports
Cell reports 16(2), 314-322 (2016). doi:10.1016/j.celrep.2016.06.008
Cell Reports, Vol 16, Iss 2, Pp 314-322 (2016)
Summary Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to ta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3ceb9355a1e6dbaca77072555126a6
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6
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
Autor: Sebastian Schmitt, Mikael Simons, Christina Sergiou, Laura Starost, Marc Ehrlich, Eugenio F. Fornasiero, Henning Urlaub, Ludovico Cantuti-Castelvetri, Leda Dimou, Paula Sánchez, Christine Stadelmann, Verena Schultz, Sarah Jäkel, Sunit Mandad, Wolfgang Brück, Maryam K. Fard, Claudia Wrzos, Tanja Kuhlmann, Franziska van der Meer
Publikováno v: Sci Transl Med
Science Translational Medicine
Science translational medicine 9(419), eaam7816 (2017). doi:10.1126/scitranslmed.aam7816
Science translational medicine
Investigations into brain function and disease depend on the precise classification of neural cell types. Cells of the oligodendrocyte lineage differ greatly in their morphology, but accurate identification has thus far only been possible for oligode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0b4169bf21de4d74080261a81fe797
https://europepmc.org/articles/PMC7116798/
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9
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination
Autor: Franziska van der Meer, Uta Scheidt, Verena Schultz, Erik Bahn, Claudia Wrzos, Andreas Junker, Wolfgang Brück, Christine Stadelmann
Publikováno v: Glia
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage. Although remyelination is considered beneficial in the long term, it is not known,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8447d3fed1f7f97b7995f20d0b9a1
https://www.ncbi.nlm.nih.gov/pubmed/28560740
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10
Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions
Autor: Christiane Wegner, Dieter M. Kayser, Stefan Nessler, Claudia Wrzos, Jeffrey Bennett, Christine Stadelmann, Dietmar Rudolf Thal, Anne Winkler, Wolfgang Brück, Imke Metz
Publikováno v: Acta Neuropathologica. 127:523-538
Neuromyelitis optica (NMO) is a chronic, mostly relapsing inflammatory demyelinating disease of the CNS characterized by serum anti-aquaporin 4 (AQP4) antibodies in the majority of patients. Anti-AQP4 antibodies derived from NMO patients target and d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816240df05a16b6c34cda23cd40b0a69
https://doi.org/10.1007/s00401-013-1220-8
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