Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Claudia Ulrich Hjørringgaard"'
Autor:
Peter Madsen, Thomas Kjeldsen, Claus Bekker Jeppesen, Hanne H. F. Refsgaard, Trine Porsgaard, Helle Naver, Sanne Gram-Nielsen, Frantisek Hubalek, Lone Pridal, Tina Møller Tagmose, Erica Nishimura, Inger Lautrup-Larsen, Carsten Enggaard Stidsen, Valentina Manfè, Thomas Hoeg-Jensen, Claudia Ulrich Hjørringgaard, Svend Ludvigsen, Christian Fledelius
Publikováno v:
Journal of medicinal chemistry. 64(13)
Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec is based on re-engineering of the ultra-long oral basal insulin OI3
Autor:
Claudia Ulrich Hjørringgaard, Jørgen Olsen, Graeme I. Bell, Julie Støy, Soo-Young Park, Søren Gregersen
Publikováno v:
Diabetologia
Støy, J, Olsen, J, Park, S-Y, Gregersen, S, Hjørringgaard, C U & Bell, G I 2017, ' In vivo measurement and biological characterisation of the diabetes-associated mutant insulin p.R46Q (GlnB22-insulin) ', Diabetologia, vol. 60, no. 8, pp. 1423-1431 . https://doi.org/10.1007/s00125-017-4295-2
Støy, J, Olsen, J, Park, S-Y, Gregersen, S, Hjørringgaard, C U & Bell, G I 2017, ' In vivo measurement and biological characterisation of the diabetes-associated mutant insulin p.R46Q (GlnB22-insulin) ', Diabetologia, vol. 60, no. 8, pp. 1423-1431 . https://doi.org/10.1007/s00125-017-4295-2
AIMS/HYPOTHESIS: Heterozygous mutations in the insulin gene that affect proinsulin biosynthesis and folding are associated with a spectrum of diabetes phenotypes, from permanent neonatal diabetes to MODY. In vivo studies of these mutations may lead t
Autor:
Claudia Ulrich Hjørringgaard, Brian Vad, Søren Bang Nielsen, Vladimir Matchkov, Thomas Vosegaard, Niels Chr. Nielsen, Daniel Otzen, Troels Skrydstrup
Publikováno v:
Aarhus University
Hjørringgaard, C U, Vad, B, Nielsen, S B, Matchkov, V, Vosegaard, T, Nielsen, N C, Otzen, D & Skrydstrup, T 2010, ' Cyclodextrin scaffolded alamethicin with highly efficient channel-forming properties ', Journal of Peptide Science, vol. 16, pp. 148 .
Hjørringgaard, C U, Vad, B S, Matchkov, V, Nielsen, S B, Vosegaard, T, Nielsen, N C, Otzen, D & Skrydstrup, T 2010, ' Cyclodextrin Scaffolded Alamethicin with Highly Efficient Channel-forming Properties ', 31st European Peptide Symposium, 31EPS, Copenhagen, Denmark, 05/09/2010-09/09/2010 .
Hjørringgaard, C U, Vad, B, Nielsen, S B, Matchkov, V, Vosegaard, T, Nielsen, N C, Otzen, D & Skrydstrup, T 2010, ' Cyclodextrin scaffolded alamethicin with highly efficient channel-forming properties ', Journal of Peptide Science, vol. 16, pp. 148 .
Hjørringgaard, C U, Vad, B S, Matchkov, V, Nielsen, S B, Vosegaard, T, Nielsen, N C, Otzen, D & Skrydstrup, T 2010, ' Cyclodextrin Scaffolded Alamethicin with Highly Efficient Channel-forming Properties ', 31st European Peptide Symposium, 31EPS, Copenhagen, Denmark, 05/09/2010-09/09/2010 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::59ec461f3afde3a667e191fa8c2fea51
http://pure.au.dk/portal/en/publications/cyclodextrin-scaffolded-alamethicin-with-highly-efficient-channelforming-properties(20f2c6da-eb9e-43cb-ae30-c1ac18b7add4).html
http://pure.au.dk/portal/en/publications/cyclodextrin-scaffolded-alamethicin-with-highly-efficient-channelforming-properties(20f2c6da-eb9e-43cb-ae30-c1ac18b7add4).html