Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Claudia Trefzer"'
Autor:
Markus K Muellner, Barbara Mair, Yasir Ibrahim, Claudia Kerzendorfer, Hannelore Lechtermann, Claudia Trefzer, Freya Klepsch, André C Müller, Ernestine Leitner, Sabine Macho‐Maschler, Giulio Superti‐Furga, Keiryn L Bennett, José Baselga, Uwe Rix, Stefan Kubicek, Jacques Colinge, Violeta Serra, Sebastian MB Nijman
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 2, Pp 1-16 (2015)
Abstract Some mutations in cancer cells can be exploited for therapeutic intervention. However, for many cancer subtypes, including triple‐negative breast cancer (TNBC), no frequently recurring aberrations could be identified to make such an approa
Externí odkaz:
https://doaj.org/article/034f9bbfb32d4b97b689c5cf0c981ff6
Autor:
Claudia Trefzer, Gregory I. Vladimer, Keiryn L. Bennett, Alexey Stukalov, Hans P. Kiener, Johannes W. Bigenzahn, Barbara Herdy, Tamara Theil, Jacques Colinge, Johannes Holinka, Giulio Superti-Furga, Thomas Karonitsch, Chris Soon Heng Tan
Publikováno v:
European Journal of Immunology. 45:1500-1511
Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76819f2c13048956294f8944a1877c5
https://doi.org/10.1002/eji.201444979
https://doi.org/10.1002/eji.201444979
Autor:
Silvia Buroni, Henrieta Škovierová, Elisabetta Molteni, Giovanna Riccardi, Florence Pojer, Claudia Trefzer, Vadim Makarov, Stewart T. Cole, Adela Bobovská, Simone Nenci, Katarína Mikušová, Kai Johnsson, Maria Rosalia Pasca
Publikováno v:
Journal of the American Chemical Society; Vol 134
Benzothiazinones (BTZs) are antituberculosis drug candidates with nanomolar bactericidal activity against tubercle bacilli. Here we demonstrate that BTZs are suicide substrates of the FAD-dependent decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase Dp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed48cf8d81ce98ec1b431a3aeef0dbc
Autor:
Robert Kralovics, Stefan Kubicek, Sebastian M.B. Nijman, Christoph Bock, Tiina Berg, Marco P. Licciardello, M K Müllner, Michael Schuster, Jacques Colinge, Giulio Superti-Furga, Thomas Penz, Gerhard Dürnberger, Claudia Kerzendorfer, Bernd Boidol, Claudia Trefzer, Sara Sdelci
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2015, 34 (29), pp.3780-3790. ⟨10.1038/onc.2014.319⟩
Europe PubMed Central
Oncogene, Nature Publishing Group, 2015, 34 (29), pp.3780-3790. ⟨10.1038/onc.2014.319⟩
Europe PubMed Central
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90028faf5dc5a9043d69bad24a5b2b5c
https://hal.umontpellier.fr/hal-02287227
https://hal.umontpellier.fr/hal-02287227
Autor:
André C. Müller, Giulio Superti-Furga, Henning J. Jessen, Keiryn L. Bennett, Roberto Giambruno, Alexandre Hofer, Gregor S. Cremosnik, Claudia Trefzer
Publikováno v:
Chemistry-A European Journal
Phosphoanhydrides (P-anhydrides) are ubiquitously occurring modifications in nature. Nucleotides and their conjugates, for example, are among the most important building blocks and signaling molecules in cell biology. To study and manipulate their bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e133e521563ba0af6c06449347f07e3f
https://pubmed.ncbi.nlm.nih.gov/26033174
https://pubmed.ncbi.nlm.nih.gov/26033174
Autor:
Giulio Superti-Furga, Thorsten Klampfl, Manuela Gridling, Stefan Kubicek, Branka Radic, Claudia Trefzer, Vincent A. Blomen, Kilian Huber, Robert Kralovics, Cristina Mayor-Ruiz, Georg E. Winter, Thijn R. Brummelkamp, Doris Chen, Oscar Fernandez-Capetillo, Richard Kumaran Kandasamy
Genotoxic chemotherapy is the most common cancer treatment strategy. However, its untargeted generic DNA-damaging nature and associated systemic cytotoxicity greatly limit its therapeutic applications. Here, we used a haploid genetic screen in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8608ea005a03cceef715dc161d924740
https://europepmc.org/articles/PMC4913867/
https://europepmc.org/articles/PMC4913867/
Autor:
Barbara, Herdy, Thomas, Karonitsch, Gregory I, Vladimer, Chris S H, Tan, Alexey, Stukalov, Claudia, Trefzer, Johannes W, Bigenzahn, Tamara, Theil, Johannes, Holinka, Hans P, Kiener, Jacques, Colinge, Keiryn L, Bennett, Giulio, Superti-Furga
Publikováno v:
European journal of immunology. 45(5)
Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8733e5fd33c178dcff77a1274b58484b
https://pubmed.ncbi.nlm.nih.gov/25824620
https://pubmed.ncbi.nlm.nih.gov/25824620
Autor:
Katarína Mikušová, William R. Jacobs, Takushi Kaneko, Stanislav Huszár, Gurdyal S. Besra, Kai Johnsson, Khisi E. Mdluli, Peter G. Schultz, Klaus Fütterer, Jianing Wang, Peng-Yu Yang, Scott G. Franzblau, Rajkumar Halder, Feng Wang, Arnab Chatterjee, Morad Hassani, S. Whitney Barnes, John Kim, Scott H. Robbins, Zhenkun Ma, Yong Zhang, John R. Walker, Claudia Trefzer, Insha Ahmad, Brian Weinrick, Sarah M. Batt, Dhinakaran Sambandan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0376a6732f543768ce98a62844b4e9
https://europepmc.org/articles/PMC3785748/
https://europepmc.org/articles/PMC3785748/
Autor:
Rajkumar Halder, Sarah M. Batt, Takushi Kaneko, Dhinakaran Sambandan, John Kim, Insha Ahmad, Jianing Wang, Khisi E. Mdluli, Peng-Yu Yang, John R. Walker, Scott G. Franzblau, Feng Wang, Yong Zhang, Morad Hassani, Peter G. Schultz, Claudia Trefzer, Brian Weinrick, Zhenkun Ma, Katarína Mikušová, William R. Jacobs, S. Whitney Barnes, Kai Johnsson, Klaus Fütterer, Arnab Chatterjee, Stanislav Huszár, Gurdyal S. Besra, Scott H. Robbins
Publikováno v:
Proceedings of the National Academy of Sciences; Vol 110
A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against both drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb) and sterilizes Mtb in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abcc557805fa46886967cdb608799fd
https://doi.org/10.1073/pnas.1309171110
https://doi.org/10.1073/pnas.1309171110
Autor:
Patricia Schneider, Marlon J. Hinner, Makarov Vadim A, Claudia Trefzer, Monica Rengifo-Gonzalez, Kai Johnsson, Stewart T. Cole
Publikováno v:
Journal of the American Chemical Society. 132(39)
Benzothiazinones (BTZs) form a new class of potent antimycobacterial agents. Although the target of BTZs has been identified as decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1), their detailed mechanism of action remains obscure. Here we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20326c81a00a0ef5affb138b07776ae
https://pubmed.ncbi.nlm.nih.gov/20828197
https://pubmed.ncbi.nlm.nih.gov/20828197