Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

Autor: Rasmus D Wollenberg, Søren S Donau, Manuel H Taft, Zoltan Balázs, Sven Giese, Claudia Thiel, Jens L Sørensen, Thorbjørn T Nielsen, Henriette Giese, Dietmar J Manstein, Reinhard Wimmer, Teis E Sondergaard

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0235568 (2020)

Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides whi

Externí odkaz: https://doaj.org/article/cdef8469221e44b98270913f548467c7

The Conserved Lysine-265 Allosterically Modulates Nucleotide- and Actin-binding Site Coupling in Myosin-2

Autor: Vincent A. Behrens, Stefan Münnich, Georg Adler-Gunzelmann, Claudia Thiel, Arnon Henn, Sharissa L. Latham, Manuel H. Taft

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Myosin motor proteins convert chemical energy into force and movement through their interactions with nucleotide and filamentous actin (F-actin). The evolutionarily conserved lysine-265 (K265) of the myosin-2 motor from Dictyostelium discoid

Externí odkaz: https://doaj.org/article/eaaa298420cf47cbb9f594859b1b21ab

Spotted Fever Group Rickettsiae in Ticks, Germany

Autor: Cornelia Silaghi, Dietmar Hamel, Claudia Thiel, Kurt Pfister, Martin Pfeffer

Publikováno v: Emerging Infectious Diseases, Vol 17, Iss 5, Pp 890-892 (2011)

To explore increased risk for human Rickettsia spp. infection in Germany, we investigated recreational areas and renatured brown coal surface-mining sites (also used for recreation) for the presence of spotted fever group rickettsiae in ticks. R. rao

Externí odkaz: https://doaj.org/article/ec6f720060af42af80037ca9e4e62751

Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium

Autor: Zoltan Balázs, Thorbjørn Terndrup Nielsen, Henriette Giese, Jens Laurids Sørensen, Teis Esben Sondergaard, Søren Sejer Donau, Manuel H. Taft, Sven Giese, Rasmus Dam Wollenberg, Reinhard Wimmer, Claudia Thiel, Dietmar J. Manstein

Publikováno v: PLoS ONE
Wollenberg, R D, Donau, S S, Taft, M H, Balázs, Z, Giese, S, Thiel, C, Sørensen, J L, Nielsen, T T, Giese, H, Manstein, D J, Wimmer, R & Sondergaard, T E 2020, ' Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium ', PLOS ONE, vol. 15, no. 6, e0235568 . https://doi.org/10.1371/journal.pone.0235568
PLoS ONE, Vol 15, Iss 6, p e0235568 (2020)

Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbf4fe31da13b89de8a5118c0244282
https://pubmed.ncbi.nlm.nih.gov/32598376

Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin

Autor: Sven Giese, Claudia Thiel, Henriette Giese, Zoltan Balázs, Manuel H. Taft, Dietmar J. Manstein, Rasmus Dam Wollenberg, Teis Esben Sondergaard

Publikováno v: Wollenberg, R, Taft, M H, Giese, S, Thiel, C, Balázs, Z, Giese, H, Manstein, D & Sondergaard, T E 2019, ' Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin ', Journal of Biological Chemistry, vol. 294, no. 4, pp. 1328-1337 . https://doi.org/10.1074/jbc.RA118.005408

The cyanoacrylate compound phenamacril (also known as JS399-19) is a recently identified fungicide that exerts its antifungal effect on susceptible Fusarium species by inhibiting the ATPase activity of their myosin class I motor domains. Although muc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be3d247fde259987709350467f1a35f
https://vbn.aau.dk/da/publications/0589bd35-b0a1-4a69-9241-a3b89594c190