Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Claudia Thäte"'
Autor:
Claudia Thäte, Christiane Woischwill, Gunda Brandenburg, Matthias Müller, Sonja Böhm, Joachim Baumgart
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 1960-1969 (2021)
Guidelines regulating the development of advanced therapy medicinal products (ATMPs) request nonclinical data for toxicity, biodistribution and tumorigenicity before mesenchymal stromal cell (MSC) products can be administered in large clinical trials
Externí odkaz:
https://doaj.org/article/86385dd8a2ad4d74bbb2a26777b6e766
Autor:
Matthias Müller, Joachim Baumgart, Claudia Thäte, Gunda Brandenburg, Christiane Woischwill, Sonja Böhm
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1960-1969 (2021)
Toxicology Reports, Vol 8, Iss, Pp 1960-1969 (2021)
Graphical abstract
Highlights • Good safety profile of mesenchymal stromal cells (MSCs) without toxicity findings. • MSC biodistribution showed primary distribution to the lung and short persistence. • No tumor formation observed after 6 m
Highlights • Good safety profile of mesenchymal stromal cells (MSCs) without toxicity findings. • MSC biodistribution showed primary distribution to the lung and short persistence. • No tumor formation observed after 6 m
Autor:
A. König, Ilya Chumakov, D. Lepaslier, B. Gawin, R. Bhogal, G. Zehetner, Gail A. P. Bruns, Claudia Thäte, Barbara Klamt, Manfred Gessler
Publikováno v:
Genomics. 30:37-45
The WAGR syndrome (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) deletion region on chromosome 11p13 has been extensively characterized by deletion analysis and long-range restriction mapping. A dense probe set is available
Publikováno v:
Scopus-Elsevier
The Wilms' tumour suppressor gene WT1 encodes a zinc finger protein that is mutated in a subset of Wilms' tumours. Mutation screening and animal studies revealed essential roles during development and later function of the kidneys and the entire geni
Autor:
Wolfram Scheurlen, A. Weirich, J. Mareš, Michael Schulze, Barbara Klamt, Peter Goetz, Roman Kodet, Claudia Thäte, Manfred Gessler, Norbert Graf
Publikováno v:
Genes, chromosomescancer. 22(4)
An extended analysis for loss of heterozygosity (LOH) on eight chromosomes was conducted in a series of 82 Wilms tumors. Observed rates of allele loss were: 9.5% (1p), 5% (4q), 6% (6p), 3% (7p), 9.8% (11q), 28% (11p15), 13.4% (16q), 8.8% (18p), and 1
Autor:
Thomas B. Shows, Arne König, S. Tsaoussidou, Manfred Gessler, Barbara Klamt, Carol Jones, Claudia Thäte, Michael J. Higgins, J. Pongratz
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 6(6)
A NotI end fragment library has been constructed for human Chromosome (Chr) 11p. Seventy-two clones were mapped to chromosomal subregions by use of somatic cell hybrids. The clones detect 44 different CpG islands, and we have isolated cosmid contigs