Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Claudia T. Flynn"'
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007674 (2019)
Viral myocarditis is a serious disease, commonly caused by type B coxsackieviruses (CVB). Here we show that innate immune protection against CVB3 myocarditis requires the IFIT (IFN-induced with tetratricopeptide) locus, which acts in a biphasic manne
Externí odkaz:
https://doaj.org/article/d298d946f1f745ab86b4b830b59d3960
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005861 (2016)
Innate immune responses in general, and type I interferons (T1IFNs) in particular, play an important and often essential role during primary viral infections, by directly combatting the virus and by maximizing the primary adaptive immune response. Se
Externí odkaz:
https://doaj.org/article/7426581dda9f425b983cb0d675ef65e3
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Previous research suggests that hepatocytes catabolize chemical toxins but do not remove microbial agents, which are filtered out by other liver cells (Kupffer cells and endothelial cells). Here we show that, contrary to current understanding, hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d451f6f70fb5073e21aabbe6767d54
http://europepmc.org/articles/PMC7568585
http://europepmc.org/articles/PMC7568585
Publikováno v:
Autophagy
Almost a billion people worldwide are chronically undernourished. Herein, using a mouse model of coxsackievirus B3 (CVB3) infection, we report that a single day of food restriction (FR) markedly increases susceptibility to attenuated enterovirus infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acca3c9808e23ebfcb7f5bd684c9b383
https://europepmc.org/articles/PMC8007148/
https://europepmc.org/articles/PMC8007148/
Autor:
Christopher C Kemball, Stephanie Harkins, Jason K Whitmire, Claudia T Flynn, Ralph Feuer, J Lindsay Whitton
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000618 (2009)
Many viruses encode proteins whose major function is to evade or disable the host T cell response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively strong T cell responses. Herein, we employ transgenic CD4(+) and
Externí odkaz:
https://doaj.org/article/cfa169a10cf548db966c297a81118ccb
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2906 (2008)
There is compelling evidence to support the idea that autophagy has a protective function in neurons and its disruption results in neurodegenerative disorders. Neuronal damage is well-documented in the brains of HIV-infected individuals, and evidence
Externí odkaz:
https://doaj.org/article/56019c7dd51c4684b54b36e56a5dad79
Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007674 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007674 (2019)
Viral myocarditis is a serious disease, commonly caused by type B coxsackieviruses (CVB). Here we show that innate immune protection against CVB3 myocarditis requires the IFIT (IFN-induced with tetratricopeptide) locus, which acts in a biphasic manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cf8f8bb89dcc05131052bf01c99585
http://europepmc.org/articles/PMC6453442
http://europepmc.org/articles/PMC6453442
Publikováno v:
The Journal of Immunology. 204:248.3-248.3
Liver has many biological functions, including (but by no means limited to) the removal, from the blood, of various pathogenic organisms. This phenomenon has been best-studied for bacteria, and is thought to be mainly mediated by Kupffer cells and si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::883acebfa9f0f06b85d497bf8fd314c3
https://doi.org/10.4049/jimmunol.204.supp.248.3
https://doi.org/10.4049/jimmunol.204.supp.248.3
Publikováno v:
Autophagy
RNA viruses modify intracellular membranes to produce replication scaffolds. In pancreatic cells, coxsackievirus B3 (CVB3) hijacks membranes from the autophagy pathway, and in vivo disruption of acinar cell autophagy dramatically delays CVB3 replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8025dc2170fb150c6683f6cb74a5fca5
https://doi.org/10.1080/15548627.2015.1063769
https://doi.org/10.1080/15548627.2015.1063769
Autor:
Claudia T. Flynn, Kwesi Frimpong-Boateng, J. Lindsay Whitton, Taishi Kimura, Stephanie Harkins
Publikováno v:
Virology. 512
Type B coxsackieviruses (CVB) can cause myocarditis and dilated cardiomyopathy (DCM), a potentially-fatal sequela that has been correlated to the persistence of viral RNA. Herein, we demonstrate that cardiac RNA persistence can be established even af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd64c916165aa91360e1ea08ff207e5
https://pubmed.ncbi.nlm.nih.gov/28950225
https://pubmed.ncbi.nlm.nih.gov/28950225