Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Claudia Stross"'
Autor:
Jan Stindt, Philipp Ellinger, Claudia Stross, Verena Keitel, Dieter Häussinger, Sander H J Smits, Ralf Kubitz, Lutz Schmitt
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20562 (2011)
Homologous recombination in Saccharomyces cerevisiae is a well-studied process. Here, we describe a yeast-recombination-based approach to construct and mutate plasmids containing the cDNA of the human bile salt export pump (BSEP) that has been shown
Externí odkaz:
https://doaj.org/article/bdcdee7e959f46709a3483635d6b4003
Autor:
Christian M. Lange, Robert Tampé, Markus Schneider, Georg Dultz, Stefan Zeuzem, Antoine Marion, Ricardo M. Biondi, Tetsuro Shimakami, Tobias M. Zeitler, Rebecca M. Richter, Iris Antes, Christoph Welsch, Christian Grimm, Claudia Stross, Kazuhisa Murai, Daisuke Yamane, Min Kyung Yi, Katrin Bäumer
Publikováno v:
J Biol Chem
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these inhibitors, the mutations do not
Autor:
Carola Dröge, Ralf Kubitz, Jan Stindt, Ulrike Teufel, Daniel Wenning, Guido Engelmann, Dieter Häussinger, Stefanie Kluge, Claudia Stross, Christa Flechtenmacher, Claus Peter Schmitt
Publikováno v:
Pediatric Transplantation. 20:987-993
PFIC due to BSEP mutations (PFIC type 2) often necessitates OLT. It has recently been recognized that some PFIC-2 patients develop phenotypic disease recurrence post-OLT due to the appearance of anti-BSEP antibodies. Here, we describe a boy who becam
Autor:
Stefanie Kluge, Verena Keitel, Carola Dröge, Dieter Häussinger, Ralf Kubitz, Claudia Stross, Jan Stindt, Nathalie Walter
Publikováno v:
Clinical Reviews in Allergy & Immunology. 48:273-284
Severe cholestasis may result in end-stage liver disease with the need of liver transplantation (LTX). In children, about 10 % of LTX are necessary because of cholestatic liver diseases. Apart from bile duct atresia, three types of progressive famili
Autor:
Ralf Kubitz, Katrin Weissenberger, Dieter Häussinger, Elisabeth Winands, Stefanie Kluge, Claudia Stross
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 305:G722-G730
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major uptake transporter for bile salts into liver parenchymal cells, and PKC-mediated endocytosis was shown to regulate the number of Ntcp molecules at the plasma membrane. In this stu
Autor:
Olga Domanova, Stefanie Mühlfeld, Verena Keitel, Dieter Häussinger, Thomas Berlage, Ralf Kubitz, Angelika Helmer, Claudia Stross
Publikováno v:
Hepatology. 56:2387-2397
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcell
Autor:
Stefan Zeuzem, Christian M. Lange, Claudia Stross, Monazza Q. Ahmad, K Haselow, Christoph Welsch, Tetsuro Shimakami
Publikováno v:
Scientific Reports
High replicative fitness is a general determinant of a multidrug resistance phenotype and may explain lower sensitivity to direct-acting antiviral agents (DAAs) in some hepatitis C virus genotypes. Genetic diversity in the molecular target site of pe
Autor:
Florian Brinkert, Rainer Ganschow, Takehisa Ueno, Khalid A. Noli, Ralf Kubitz, Guido Engelmann, Claudia Stross, Lutz Schmitt, Stefanie Kluge, Patrick Gerner, Ross W. Shepherd, Carola Dröge, Constanze Wiek, Anil Dhawan, Ieva Pukite, Enke Grabhorn, A.S. Knisely, Verena Keitel, Ulrich Baumann, Helmut Hanenberg, Dieter Häussinger, Jan Stindt
Progressive familial intrahepatic cholestasis type 2 (PFIC-2) is caused by mutations in ABCB11, encoding the bile salt export pump (BSEP). In 2009, we described a child with PFIC-2 who developed PFIC-like symptoms after orthotopic liver transplantati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ca398470fd25527c1b3fcef9849e20
https://www.ncbi.nlm.nih.gov/pubmed/26516723
https://www.ncbi.nlm.nih.gov/pubmed/26516723
Publikováno v:
bchm. 390:235-244
Members of all three classes of the protein kinase C (PKC) family including atypical PKCzeta (PKCζ) are involved in central functions of liver parenchymal cells. However, expression and localization of PKCiota (PKCι), the highly homologous atypical
Autor:
Fred Schaper, Claudia Stross, Christa Gerlach, Simone Radtke, Heike M. Hermanns, Peter C. Heinrich, Thomas Clahsen, Rudolf Volkmer-Engert
Publikováno v:
Journal of Biological Chemistry. 281:8458-8468
Down-regulation of interleukin (IL)-6-type cytokine signaling has been shown to occur, among other mechanisms, via induction of the feedback inhibitor SOCS3 (suppressor of cytokine signaling 3). Binding of SOCS3 to the phosphorylated Tyr(759) in the