Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Claudia Stark"'
Autor:
Peter Stei, Fiona Sewell, Deborah Ockert, Helen Palmer, Marija Popovic, Elizabeth Donald, Sophie Kervyn, Wendy Roosen, Vicente Nogues, Linda Allais, Jean-Luc Delongeas, Matthias Festag, Kevin Somers, Ankie Schoenmakers, Kathryn Chapman, Sally Robinson, Claudia Stark
Publikováno v:
Regulatory Toxicology and Pharmacology. 67:27-38
Short term toxicity studies are conducted in animals to provide information on major adverse effects typically at the maximum tolerated dose (MTD). Such studies are important from a scientific and ethical perspective as they are used to make decision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68b6a65df8c912a87ad9e918ce987cf
https://doi.org/10.1016/j.yrtph.2013.04.003
https://doi.org/10.1016/j.yrtph.2013.04.003
Autor:
Thomas Kissner, Joanna L Parish, Jeanet Løgsted, Silvana Venturella, Anette Blak Grossi, Sofiene Mhedhbi, Jorgen Schützsack, Julia Schlichtiger, Noel Downes, Claudia Stark, Peter Heining, David Cameron, Manual Sanchez-Felix, Warren Harvey, Matthias Festag, Ingrid Brück Bøgh, Vanessa Ross, Stéphane Milano, Margaret Weaver
Publikováno v:
Toxicologic pathology. 44(3)
Minipigs have been used for dermal drug development studies for decades, and they are currently more frequently considered as the second nonrodent species for pivotal nonclinical studies, in lieu of the dog or nonhuman primate, for compounds delivere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9317c2b3a21efbe5bbb662a8fc1a940d
https://pubmed.ncbi.nlm.nih.gov/26674803
https://pubmed.ncbi.nlm.nih.gov/26674803
Autor:
Elizabeth Donald, Vicente Nogues, Kamil Nahas, Peter Stei, Matthias Festag, Kathryn Chapman, Lynne Waterson, Kirsty Quinn, Kev Somers, Jean-Luc Delongeas, Sally Robinson, Claudia Stark, Nigel Pickersgill, Sophie Kervyn, David Dreher, Deborah Ockert, Sally Old, Ann Lampo
Publikováno v:
Regulatory Toxicology and Pharmacology. 50:345-352
Regulatory guidelines indicate acute toxicity studies in animals are considered necessary for pharmaceuticals intended for human use. This is the only study type where lethality is mentioned as an endpoint. The studies are carried out, usually in rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b781e257a7cdc12a895acd78881556
https://doi.org/10.1016/j.yrtph.2007.11.009
https://doi.org/10.1016/j.yrtph.2007.11.009
Publikováno v:
Handbook of experimental pharmacology. 232
Nonclinical safety pharmacology and toxicology testing of drug candidates assess the potential adverse effects caused by the drug in relation to its intended use in humans. Hazards related to a drug have to be identified and the potential risks at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd9ed51c65d8138ab6a40ccb716ad8c7
https://pubmed.ncbi.nlm.nih.gov/26489827
https://pubmed.ncbi.nlm.nih.gov/26489827
Autor:
Thomas Steger-Hartmann, Claudia Stark
Publikováno v:
New Approaches to Drug Discovery ISBN: 9783319289120
Nonclinical safety pharmacology and toxicology testing of drug candidates assess the potential adverse effects caused by the drug in relation to its intended use in humans. Hazards related to a drug have to be identified and the potential risks at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db1b6357bce22bcd380b1501a9c03230
https://doi.org/10.1007/164_2015_16
https://doi.org/10.1007/164_2015_16
Autor:
Yvon Rabemampianina, Lieve Lammens, Markus Stephan-Gueldner, Friedrich von Landenberg, Claudia Stark, Olympe Depelchin, Rudolf Pfister, David M. Smith, Robert Combes, Ruediger Hack, Joerg Luft, Barry Phillips, Soren Dyring Jacobsen, Susan Sparrow
Publikováno v:
Regulatory Toxicology and Pharmacology. 41:95-101
A working party, comprising two animal welfare organisations and some 12 pharmaceutical companies in Europe, was established to minimise the use of the dog in safety testing. As first step, the participants defined the major objectives of preliminary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddeeee3a8ebf7ffebe09170b4c03e50
https://doi.org/10.1016/j.yrtph.2004.10.006
https://doi.org/10.1016/j.yrtph.2004.10.006
Autor:
Stefan Kaulfuss, Michael Jeffers, Martin Michels, Alwin Krämer, Lena Herbst, Katja Zimmermann, Olaf Panknin, Michael Brüning, Holger Hess-Stumpp, Hartmut Rehwinkel, Stefan Pusch, Roland Neuhaus, Katja Prelle, Karl Ziegelbauer, Sven Ring, Michael Brands, Andreas von Deimling, Claudia Stark
Publikováno v:
Cancer Research. 76:2645-2645
Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that is frequently mutated in certain cancers, with incidence rates ranging from 7-90% for glioma, chondrosarcoma, intrahepatic cholangiocarcinoma and AML. Wildtype IDH1 (wtIDH1) catalyzes the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0800beaca2bde404f2e8261e4aeda29
https://doi.org/10.1158/1538-7445.am2016-2645
https://doi.org/10.1158/1538-7445.am2016-2645
Publikováno v:
Journal of pharmacological and toxicological methods. 62(3)
As part of the RETHINK European FP6 Project an overview of the acceptability and usefulness of minipigs has been carried out in the regulatory arenas of human and veterinary pharmaceuticals, food additives, cosmetics, biocides and agrochemicals, chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7655dd67cd8c15538dfe9a5956fdbfc8
https://pubmed.ncbi.nlm.nih.gov/20601024
https://pubmed.ncbi.nlm.nih.gov/20601024
Autor:
Lieve Lammens, Peter Stei, Markus Stephan-Gueldner, Rudolf Pfister, Claudia Stark, David M. Smith, Yvon Rabemampianina, Annie Delaunois, Joerg Luft, Friedrich von Landenberg, Ruediger Hack, Barry Phillips, Sue Sparrow, Robert Combes, Anna-Mette Paarup
Publikováno v:
Toxicology. 231:97-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf2e8d8ca51bdd2263748465ae564f8
https://doi.org/10.1016/j.tox.2006.11.020
https://doi.org/10.1016/j.tox.2006.11.020