Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Claudia Sissi"'
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
G-quadruplexes (G4s) are nucleic acid secondary structures detected within human chromosomes, that cluster at gene promoters and enhancers. This suggests that G4s may play specific roles in the regulation of gene expression. Within a distinct subgrou
Externí odkaz:
https://doaj.org/article/1fe8e29107d04ed9b4b871c6a61fa80d
Autor:
Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni, Costantino Floris, Antonella Rosa, Mariella Nieddu, Pierluigi Caboni, Claudia Sissi, Andrea Angeli, Claudiu T. Supuran, Filippo Cottiglia
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 539-548 (2020)
In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical invest
Externí odkaz:
https://doaj.org/article/ba38eeee14924a808934f20776c11ded
Autor:
Manlio Palumbo, Claudia Sissi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11984 (2022)
Winning the war against cancer represents a major goal currently [...]
Externí odkaz:
https://doaj.org/article/96a63fbb57e3404a9c0820babb79c29d
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 373 (2022)
In the past two decades, significant efforts have been put into designing small molecules to target selected genomic sites where DNA conformational rearrangements control gene expression. G-rich sequences at oncogene promoters are considered good poi
Externí odkaz:
https://doaj.org/article/be7b308e7f6145ed85ce118636e2c203
Autor:
Silvia Da Ros, Giulia Nicoletto, Riccardo Rigo, Silvia Ceschi, Eleonora Zorzan, Mauro Dacasto, Mery Giantin, Claudia Sissi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 329 (2020)
The regulation of conformational arrangements of gene promoters is a physiological mechanism that has been associated with the fine control of gene expression. Indeed, it can drive the time and the location for the selective recruitment of proteins o
Externí odkaz:
https://doaj.org/article/635fe677dcd64618aa409350e23683f0
Autor:
Manlio Palumbo, Roberto Porta, Rodolfo Pescador, Danilo Moltrasio, Claudia Sissi, Lorena Lucatello, Elena Vianini, Barbara Gatto
Publikováno v:
International Journal of Molecular Sciences, Vol 9, Iss 6, Pp 1008-1023 (2008)
Cathepsin G (CatG) is a chymotrypsin-like protease released upon degranulation of neutrophils. In several inflammatory and ischaemic diseases the impaired balance between CatG and its physiological inhibitors leads to tissue destruction and platelet
Externí odkaz:
https://doaj.org/article/6e0c79bf11a943dd85ac6d2a5b75c74d
Publikováno v:
ARKIVOC, Vol 2004, Iss 5, Pp 204-218 (2004)
Externí odkaz:
https://doaj.org/article/0ed6353e8cb84d809351025d9599f5e4
Autor:
Silvia Da Ros, Eleonora Zorzan, Mery Giantin, Lara Zorro Shahidian, Manlio Palumbo, Mauro Dacasto, Claudia Sissi
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103876 (2014)
Downregulation of gene expression by induction of non-canonical DNA structures at promotorial level is a novel attractive anticancer strategy. In human, two guanine-rich sequences (h_kit1 and h_kit2) were identified in the promotorial region of oncog
Externí odkaz:
https://doaj.org/article/c047fd252dd2497d96aa64573b5c85dc
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58529 (2013)
The physiological role(s) played by G-quadruplexes renders these 'non-canonical' DNA secondary structures interesting new targets for therapeutic intervention. In particular, the search for ligands for selective recognition and stabilization of G-qua
Externí odkaz:
https://doaj.org/article/cdb5d662e5814e3ba7389f1523df69bd
Autor:
Michele Ghezzo, Claudia Sissi
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 148:5375-5385
I-motifs are tetra-helixes that may form in cytosine-rich strands. They are based on cytosine–cytosine+ base pairs that require the N3 hemi-protonation of the nucleobases, and therefore, the stability of these non-canonical DNA arrangements depends