Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Claudia Sippel"'
1
Akademický článek
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
Autor: Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L. Will, Divita Garg, Claudia Sippel, Tobias G. Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF H
Externí odkaz: https://doaj.org/article/816cddccf4d4425e993bdca998fb63bd
Zobrazit plný text záznamu
2
A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands
Autor: Stefania Staibano, Maria Romano, Felix Hausch, Andreas Bracher, Fabian H. Knaup, Claudia Sippel, Xixi Feng
Selective inhibition of FKBP51 has emerged as possible novel treatment for diseases like major depressive disorder, obesity, chronic pain, and certain cancers. The current FKBP51 inhibitors are rather large, flexible, and have to be further optimized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfded6e8a132f98d9a6b4ee0a95c3ab4
http://hdl.handle.net/11588/816340
Zobrazit plný text záznamu
3
Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins
Autor: Sebastian Pomplun, Kensuke Shima, Jan Rupp, Hui Ting Toh, Can Ünal, Michael Steinert, Andreas Hähle, Felix Hausch, Claudia Sippel, Alina Klages, Benedikt Rieß, Guido Hansen, Donald Tay, Ho Sup Yoon, Peter R. Preiser, Andreas Bracher
Publikováno v: Journal of Medicinal Chemistry. 61:3660-3673
FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fe0836f2c1f18eb927084c982ae4bd
https://doi.org/10.1021/acs.jmedchem.8b00137
Zobrazit plný text záznamu
4
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
Autor: Felix Hausch, Tobias G. Kapp, Komal Soni, Michael Sattler, Horst Kessler, Kenji Schorpp, Cindy L. Will, Divita Garg, Reinhard Lührmann, Thorsten Bach, Claudia Sippel, Kamyar Hadian, Pravin Kumar Ankush Jagtap, Harish K. Potukuchi, Tomáš Kubelka
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
'Nature Communications ', vol: 11, pages: 5621-1-5621-11 (2020)
Nat. Commun. 11:5621 (2020)
Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM interactions mediate heterodimerization of the constitutive splicing factors U2AF6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7c7bf8fe0cab2d397f14b562196e6e
https://mediatum.ub.tum.de/doc/1601975/document.pdf
Zobrazit plný text záznamu
5
Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States
Autor: Felix Hausch, Claudia Sippel, Michael Sattler, Pravin Kumar Ankush Jagtap, Sam Asami, Ville R. I. Kaila
Publikováno v: Angew. Chem.-Int. Edit. 58, 9429-9433 (2019)
The recently discovered SAFit class of inhibitors against the Hsp90 co-chaperone FKBP51 show greater than 10 000-fold selectivity over its closely related paralogue FKBP52. However, the mechanism underlying this selectivity remained unknown. By combi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0060658b81ad69d42012cb353bec869c
https://pubmed.ncbi.nlm.nih.gov/31549791
Zobrazit plný text záznamu
6
Selective inhibitors of the FK506-binding protein 51 by induced fit
Autor: Paula Fernandez-Vizarra, Gerd Ruhter, Serena Cuboni, Mathias V. Schmidt, S. Gaali, Alexander Kirschner, Felix Hausch, Georgia Balsevich, Elisabeth B. Binder, Anthony S. Zannas, Andreas Bracher, Christian Namendorf, Chadi Touma, Christian Kozany, Rika Draenert, Osborne F. X. Almeida, Manfred Uhr, Jakob Hartmann, Claudia Sippel
Publikováno v: Nature Chemical Biology. 11:33-37
The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. Drug discovery for FKBP51 has been hampered by the inability to pharmacologically differ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8f83ab1f89a82c7102536a7a797395
https://doi.org/10.1038/nchembio.1699
Zobrazit plný text záznamu
7
Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues
Autor: Alexander Pöthig, Claudia Sippel, Eberhardt Herdtweck, Johannes Richers, Felix Hausch, Konrad Tiefenbacher
Neurotrophic natural products hold potential as privileged structures for the development of therapeutic agents against neurodegeneration. However, only a few studies have been conducted to investigate a common pharmacophoric motif and structure-acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82c567aeea6499c8c4ebb877748ba0c
Zobrazit plný text záznamu
9
Vipp1 is required for basic thylakoid membrane formation but not for the assembly of thylakoid protein complexes
Autor: Peter Westhoff, Lutz A. Eichacker, Gerhard Wanner, Jürgen Soll, Friederich Ossenbühl, Bernhard Stein, Jörg Meurer, Won Kyong Cho, Ute C. Vothknecht, Elena Aseeva, Claudia Sippel
Publikováno v: Plant Physiology and Biochemistry. 45:119-128
Vipp1 ( v esicle i nducing p rotein in p lastids 1 ) is found in cyanobacteria and chloroplasts where it is essential for thylakoid formation. Arabidopsis thaliana mutant plants with a reduction of Vipp1 to about 20% of wild type content become albin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc46cd89058912e0fce79461963c4591
https://doi.org/10.1016/j.plaphy.2007.01.005
Zobrazit plný text záznamu
10
Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands
Autor: Claudia Sippel, Xixi Feng, Andreas Bracher, Felix Hausch
Publikováno v: Journal of medicinal chemistry. 58(19)
The FK506-binding protein 51 (FKBP51) is a promising drug target for the treatment of stress-related psychiatric or metabolic disorders. Just recently, the first selective ligands for FKBP51 were reported based on an induced fit mechanism, but they a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558e38432c2c94333e87763d5c5e6e58
https://pubmed.ncbi.nlm.nih.gov/26419422
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje