Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Claudia Selck"'
Autor:
Prerak Trivedi, Gaurang Jhala, David J. De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W. Kay, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibitin
Externí odkaz:
https://doaj.org/article/0e2a9e262b5049768e050d08ba434b1c
Autor:
Allison K. Maher, Katie L. Burnham, Emma M. Jones, Michelle M. H. Tan, Rocel C. Saputil, Laury Baillon, Claudia Selck, Nicolas Giang, Rafael Argüello, Clio Pillay, Emma Thorley, Charlotte-Eve Short, Rachael Quinlan, Wendy S. Barclay, Nichola Cooper, Graham P. Taylor, Emma E. Davenport, Margarita Dominguez-Villar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Although myeloid cell dysfunction has been observed in COVID-19, the underlying mechanisms remain incompletely understood. Here, the authors demonstrate that monocytes from patients with mild to moderate COVID-19 show a blunted innate immune response
Externí odkaz:
https://doaj.org/article/de001711bc5c459694d246aeb3195fa0
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is currently being explored. While clinical trial results thus far support t
Externí odkaz:
https://doaj.org/article/c20123422de1457eb5713a9aee9b25fa
Autor:
Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J. Kwong, Evan G. Pappas, Helen E. Thomas, Thomas W.H. Kay, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differe
Externí odkaz:
https://doaj.org/article/2e4f4427f77c4d30acd6cfc411dba09c
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78706 (2013)
Studies on pancreatic cell physiology rely on the investigation of exocrine and endocrine cells in vitro. Particularly, in the case of the exocrine tissue these studies have suffered from a reduced functional viability of acinar cells in culture. As
Externí odkaz:
https://doaj.org/article/aa3d04f21e3b46b3b688e0211276a37d
Autor:
Claudia Selck, Gaurang Jhala, David De George, Chun-Ting J. Kwong, Marie K. Christensen, Evan Pappas, Xin Liu, Tingting Ge, Prerak Trivedi, Axel Kallies, Helen E. Thomas, Thomas W.H. Kay, Balasubramanian Krishnamurthy
Persistent antigen exposure results in the differentiation of functionally impaired, also termed exhausted, T cells which are maintained by a distinct population of precursors of exhausted T (TPEX) cells. T cell exhaustion is well studied in the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a021ee27d4d282bb2528e974c011c67e
https://doi.org/10.1101/2023.02.12.528226
https://doi.org/10.1101/2023.02.12.528226
Autor:
Dan V Le, Claudia Selck, Chun-Ting J. Kwong, Balasubramanian Krishnamurthy, Helen E. Thomas, Thomas W.H. Kay, Lachlan J McAnaney, Krisna Tahija
Publikováno v:
Immunology & Cell Biology. 99:486-495
Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet in routine clinical use or able to achieve insulin independence in patients. In addition to this, the principles of T1D treatment r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a6759a6a2a6a7a3e7fa5c8d7d34288b
https://doi.org/10.1111/imcb.12444
https://doi.org/10.1111/imcb.12444
Autor:
Helen E. Thomas, Stacey Fynch, Balasubramanian Krishnamurthy, Tara Catterall, Satoru Akazawa, Thomas C. Brodnicki, Kate L. Graham, Claudia Selck, Thomas W.H. Kay, Chun-Ting J. Kwong, Leanne Mackin, Evan G Pappas, Andrew P. R. Sutherland, Gaurang Jhala
Publikováno v:
Diabetologia. 64:878-889
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfaf809b660ae5a6174b5dc3eb53a74
https://doi.org/10.1007/s00125-020-05378-z
https://doi.org/10.1007/s00125-020-05378-z
Autor:
Allison K. Maher, Katie L. Burnham, Emma Jones, Laury Baillon, Claudia Selck, Nicolas Giang, Rafael Argüello, Charlotte-Eve Short, Rachael Quinlan, Wendy S. Barclay, Nichola Cooper, Graham P. Taylor, Emma E. Davenport, Margarita Dominguez-Villar
Alterations in the myeloid immune compartment have been observed in COVID-19, but the specific mechanisms underlying these impairments are not completely understood. Here we examined the functionality of classical CD14+monocytes as a main myeloid cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a773ae273555a1771bee49b7f1ab28
https://doi.org/10.1101/2022.04.03.486830
https://doi.org/10.1101/2022.04.03.486830
Publikováno v:
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases ISBN: 9781315151366
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fec163501c7f51dd6388559af4e6393
https://doi.org/10.1201/9781315151366-5
https://doi.org/10.1201/9781315151366-5