Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Claudia Sardi"'
Autor:
Arianna Mazzoli, Claudia Sardi, Ludovic Breasson, Franziska Theilig, Barbara Becattini, Giovanni Solinas
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 2, Pp 94-107 (2021)
Abstract The cJun N‐terminal Kinases (JNK) emerged as a major link between obesity and insulin resistance, but their role in the loss of pancreatic β‐cell mass and function driving the progression from insulin resistance to type‐2 diabetes and
Externí odkaz:
https://doaj.org/article/c496186e3bfe449e91a07039b69b1407
PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation
Publikováno v:
JHEP Reports, Vol 3, Iss 6, Pp 100359- (2021)
Background & Aims: Phosphatidylinositides-3 kinases (PI3Ks) are promising drug targets for cancer therapy, but blockage of PI3K-AKT signalling causes hyperglycaemia, hyperinsulinaemia, and liver damage in patients, and hepatocellular carcinoma (HCC)
Externí odkaz:
https://doaj.org/article/0fe2adb7ba684bfba3441a0071b78ab9
Autor:
Marinos Kallikourdis, Elisa Martini, Pierluigi Carullo, Claudia Sardi, Giuliana Roselli, Carolina M. Greco, Debora Vignali, Federica Riva, Anne Marie Ormbostad Berre, Tomas O. Stølen, Andrea Fumero, Giuseppe Faggian, Elisa Di Pasquale, Leonardo Elia, Cristiano Rumio, Daniele Catalucci, Roberto Papait, Gianluigi Condorelli
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Abatacept is an FDA-approved drug used for treatment of rheumatoid arthritis. Here the authors show that abatacept reduces cardiomyocyte death in a mouse model of heart failure by inhibiting activation and heart infiltration of T cells and macrophage
Externí odkaz:
https://doaj.org/article/73c739f75c0e45a385907278d0b7888b
Autor:
Claudia Sardi, Stefano Garetto, Laura Capone, Valentina Galbiati, Marco Racchi, Stefano Govoni, Emiliano Giovagnoni, Jacopo Lucci
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The evolution of medical devices has led to the introduction of medical devices that include “substances” and which, due to their presentation and sites of application may resemble medicinal products. The difference between substance-based medica
Externí odkaz:
https://doaj.org/article/b68dcb2b1ab046508385e65b76535e2d
Autor:
Claudia Sardi
Publikováno v:
Medienimpulse, Vol 55, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/3c9524f4965a464e9664fce5efbecacb
Autor:
Vagner Ramon R. Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjörnstedt, Maria E. Johansson, Barbara Becattini, Per‐Anders Jansson, Giovanni Solinas
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(9)
The kinase IKKβ controls pro-inflammatory gene expression, and its activity in the liver and leukocytes was shown to drive metabolic inflammation and insulin resistance in obesity. However, it was also proposed that liver IKKβ signaling protects ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c256e554a53425baffd98af7d9f7e45
https://pubmed.ncbi.nlm.nih.gov/36001064
https://pubmed.ncbi.nlm.nih.gov/36001064
PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 6, Pp 100359-(2021)
JHEP Reports, Vol 3, Iss 6, Pp 100359-(2021)
Background & Aims Phosphatidylinositides-3 kinases (PI3Ks) are promising drug targets for cancer therapy, but blockage of PI3K-AKT signalling causes hyperglycaemia, hyperinsulinaemia, and liver damage in patients, and hepatocellular carcinoma (HCC) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4bc1a713cb3358ff32fff23b3414f5
https://pubmed.ncbi.nlm.nih.gov/34704005
https://pubmed.ncbi.nlm.nih.gov/34704005
Autor:
Tommaso Mello, Simone Camelliti, Lucia Sfondrini, Elisa Martini, Michele Sommariva, Cristiano Rumio, Marinos Kallikourdis, Fabrizio Marcucci, Claudia Sardi
Publikováno v:
Life sciences. 264
Aims Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e18762833793ec8fc91cb97b651ea3
https://pubmed.ncbi.nlm.nih.gov/33141040
https://pubmed.ncbi.nlm.nih.gov/33141040
Publikováno v:
The FASEB Journal. 32:319-329
PI3Kγ has emerged as a promising target for the treatment of obesity and insulin resistance; however, previous studies have indicated that PI3Kγ activity in pancreatic β cells is required for normal insulin secretion in response to glucose. Hence,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06fe0c2f48ee61925811b512fae3c19
https://doi.org/10.1096/fj.201700372rr
https://doi.org/10.1096/fj.201700372rr
Autor:
Claudia Sardi, Michele Sommariva, Marinos Kallikourdis, Patrizia Luchini, Andrea Emanuelli, Lucia Sfondrini, Cristiano Rumio, Lucia M Manara, Elisa Martini, Amedeo Giannoni
Publikováno v:
Microscopy Research and Technique. 80:563-569
Several studies support the role of Western-style diet (WD) in inflammatory bowel disease (IBD). Toll-like receptors/NOD-like receptors (TLRs/NLRs) are important to maintain a healthy epithelium as well as inducing inflammation. Given that dietary fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afa4bc129a235c8b094591412c0c60dd
https://doi.org/10.1002/jemt.22831
https://doi.org/10.1002/jemt.22831