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pro vyhledávání: '"Claudia S. Barros"'
Autor:
Claudia S. Barros, Torsten Bossing
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101735- (2022)
Summary: Here, we describe a protocol to remove single identified cells directly from Drosophila living brains and analyze their transcriptome. We detail the steps to harvest fluorescent cells using a capillary under epifluorescence and transmitted l
Externí odkaz:
https://doaj.org/article/d864281069e743ac86d75ef89a70a729
Autor:
Shamprasad Varija Raghu, Farhan Mohammad, Jia Yi Chua, Joanne Shi Woon Lam, Mavis Loberas, Sadhna Sahani, Claudia S. Barros, Adam Claridge-Chang
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila—neurogeneticists identify and isolate neural circuits with a binary h
Externí odkaz:
https://doaj.org/article/779a5d3b388c4a65bdbbc1659d0a7345
Autor:
Jon Gil-Ranedo, Eleanor Gonzaga, Karolina J. Jaworek, Christian Berger, Torsten Bossing, Claudia S. Barros
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2921-2933.e5 (2019)
Summary: Adult stem cells reactivate from quiescence to maintain tissue homeostasis and in response to injury. How the underlying regulatory signals are integrated is largely unknown. Drosophila neural stem cells (NSCs) also leave quiescence to gener
Externí odkaz:
https://doaj.org/article/09ce47b321fa476997223988634243e7
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Drosophila neural stem cells (NSCs) are quiescent at early larval stages but how this is regulated is unclear. Here, Ding et al. show that quiescence of NSCs is mediated by cell-contact inhibition via the Hippo pathway transmembrane proteins Crumbs a
Externí odkaz:
https://doaj.org/article/b45130861d8047d4ad7b56043c0cb9b3
Autor:
Claudia S. Barros, Claire L. Adams, Matthew Banton, Yeasmin Akther, Oliver Hanemann, Vikram Sharma
Publikováno v:
Neuro Oncol
Aims Meningioma is the most common primary intracranial tumour. Although ~80% are benign WHO grade I and show high rates of recurrence. Surgery is the main therapeutic approach, yet location can hamper complete resection and chemotherapies are ineffe
Autor:
Yeasmin Akther, Claire L. Adams, Claudia S. Barros, Oliver Hanemann, Vikram Sharma, Matthew Banton
Publikováno v:
Neuro-oncology Advances
Introduction Meningioma are the most common primary intracranial tumour. According to WHO, ~80% tumours are benign grade I. Although, some grade I tumour clinically show aggressive behaviour. Radio-surgery are the main therapeutic approaches, chemoth
Autor:
Claudia S. Barros, Torsten Bossing
Publikováno v:
Cell reports. 36(1)
Repair after traumatic injury often starts with mitotic activation around the lesion edges. Early midline cells in the Drosophila embryonic CNS can enter into division following the traumatic disruption of microtubules. We demonstrate that microtubul
Autor:
Bruce J. Aronow, Aaron Topol, Jonathan A. Ellman, Chimezie Ononenyi, Carty Nc, Angus C. Nairn, Ulrich Müller, A. Phillips, Jian Xu, Seok-Man Ho, Christopher Pittenger, Michael W. Nestor, Paul J. Lombroso, Sounak Gupta, Ethan Foscue, Kristen J. Brennand, Tyler D. Baguley, Judith L. Rapoport, Claudia S. Barros, Brigham J. Hartley, Peter Gochman, M. Xu, Pradeep Kurup
Publikováno v:
Molecular Psychiatry. 23:271-281
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR)
Autor:
Claudia S. Barros, Adam Claridge-Chang, Sadhna Sahani, Mavis Loberas, Jia Yi Chua, Farhan Mohammad, Joanne Lam, Shamprasad Varija Raghu
Publikováno v:
Molecular Brain
Molecular Brain, Vol 11, Iss 1, Pp 1-12 (2018)
Molecular Brain, Vol 11, Iss 1, Pp 1-12 (2018)
The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila—neurogeneticists identify and isolate neural circuits with a binary heterologo
Publikováno v:
Developmental Cell. 23(2):433-440
SummaryMechanisms of CNS repair have vital medical implications. We show that traumatic injury to the ventral midline of the embryonic Drosophila CNS activates cell divisions to replace lost cells. A pilot screen analyzing transcriptomes of single ce