Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Claudia Robles-Planells"'
Autor:
Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Casey Pulliam, Keegan A. Christensen, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted using the FDA-approved anti-rheumatic drug, auranofin (AF), to selectively sensitize cancer
Externí odkaz:
https://doaj.org/article/c5a3742216384e1498585e82c931ad1b
Autor:
Adam J. Rauckhorst, Gabriela Vasquez Martinez, Gabriel Mayoral Andrade, Hsiang Wen, Ji Young Kim, Aaron Simoni, Claudia Robles-Planells, Kranti A. Mapuskar, Prerna Rastogi, Emily J. Steinbach, Michael L. McCormick, Bryan G. Allen, Navjot S. Pabla, Ashley R. Jackson, Mitchell C. Coleman, Douglas R. Spitz, Eric B. Taylor, Diana Zepeda-Orozco
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101849- (2024)
Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains uncl
Externí odkaz:
https://doaj.org/article/3fd3e25948fb47dd89066773a4e94c07
Autor:
Carlos Barrera-Avalos, Pedro Briceño, Daniel Valdés, Mónica Imarai, Elías Leiva-Salcedo, Leonel E. Rojo, Luis A. Milla, Juan Pablo Huidobro-Toro, Claudia Robles-Planells, Alejandro Escobar, Francesco Di Virgilio, Gabriel Morón, Daniela Sauma, Claudio Acuña-Castillo
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103520- (2021)
Summary: T cell activation requires the processing and presentation of antigenic peptides in the context of a major histocompatibility complex (MHC complex). Cross-dressing is a non-conventional antigen presentation mechanism, involving the transfer
Externí odkaz:
https://doaj.org/article/128cfe10d0e34ee580248c3e368befc7
Autor:
Claudia Robles-Planells, Giselle Sánchez-Guerrero, Carlos Barrera-Avalos, Silvia Matiacevich, Leonel E. Rojo, Jorge Pavez, Edison Salas-Huenuleo, Marcelo J. Kogan, Alejandro Escobar, Luis A. Milla, Ricardo Fernandez, Mónica Imarai, Eugenio Spencer, Juan Pablo Huidobro-Toro, Claudio Acuña-Castillo
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation and immunogenic cell death
Externí odkaz:
https://doaj.org/article/6ea9183ca04c481c9a90f59db9b9426e
Autor:
Claudia Robles-Planells, Sofia A. Michelson, Javier Mena, Daniela Escrig, Juan L. Rojas, Giselle Sanchez-Guerrero, Ronny Hernández, Carlos Barrera-Avalos, Leonel E. Rojo, Daniela Sauma, Alexis M. Kalergis, Mónica Imarai, Ricardo Fernández, Carolina A. Robles, Elías Leiva-Salcedo, Rocio Santander, Alejandro Escobar, Claudio Acuña-Castillo
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and
Externí odkaz:
https://doaj.org/article/1ee59b96ff124ad68a8a218a86c6a7ef
Autor:
María José Hevia, Patricio Castro, Katherine Pinto, Mauricio Reyna-Jeldes, Felipe Rodríguez-Tirado, Claudia Robles-Planells, Sebastián Ramírez-Rivera, Juan Andrés Madariaga, Felipe Gutierrez, Javier López, Marcelo Barra, Erwin De la Fuente-Ortega, Giuliano Bernal, Claudio Coddou
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Gastric cancer (GC) is the one of the most prevalent cancers and one of the leading causes of cancer-induced deaths. Previously, we found that the expression of purinergic P2Y2 receptor (P2Y2R) is increased in GC samples as compared to adjacent healt
Externí odkaz:
https://doaj.org/article/2b9298a25ac64be2921e21f12f1bd8c2
Autor:
Jonathan Morales, Carlos Barrera-Avalos, Carlos Castro, Stephanie Castillo, Claudio Barrientos, Claudia Robles-Planells, Ximena López, Ernesto Torres, Margarita Montoya, Marcelo Cortez-San Martín, Denise Riquelme, Alejandro Escobar, Ricardo Fernández, Mónica Imarai, Daniela Sauma, Leonel E. Rojo, Elias Leiva-Salcedo, Claudio Acuña-Castillo
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naïve CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells generated in vitro are loade
Externí odkaz:
https://doaj.org/article/51ff5d8be73c4a808e35262395de0beb
Autor:
Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Bryan G. Allen, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
bioRxiv
Thioredoxin Reductase (TrxR) is a key enzyme in reactive oxygen species (ROS) detoxification and in redox regulation. Because cancer cells produce increased steady-state levels of ROS (i.e., superoxide and hydrogen peroxide), TrxR is viable target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db2b29a43eee17c37e62aa5bb71f97e
https://doi.org/10.1101/2023.05.07.539772
https://doi.org/10.1101/2023.05.07.539772
Autor:
Claudia Robles-Planells, Tanya Neira, Leonel E. Rojo, Alejandro Escobar, Claudio Acuña-Castillo, Claudio Cappelli, Ximena Lopez, Javier Mena, Luis A. Milla, Mónica Imarai, Carlos Barrera-Avalos, Elías Leiva-Salcedo, Ricardo Fernández
Publikováno v:
Immunotherapy. 13:309-326
Aim: Whole dead tumor cells can be used as antigen source and the induction of protective immune response could be enhanced by damage-associated molecular patterns. Materials & methods: We generated whole dead tumor cells called B16-immunogenic cell
Autor:
Melissa A. Fath, Dijie Liu, Claudia Robles-Planells, Jordan T. Ewald, Keegan A. Christensen, Spenser S. Johnson, Stephen A. Graves, Douglas R. Spitz, Yusuf Menda, M. Sue O’Dorisio
Publikováno v:
Cancer Research. 83:5034-5034
Introduction/Background: Atypical lung carcinoids and lung neuroendocrine carcinomas (NECs) are currently incurable. Most of these cancers express the C-X-C chemokine receptor 4 (CXCR4), making CXCR4 an attractive target for cancer diagnosis and trea