Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Claudia Röefzaad"'
Autor:
Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas
Externí odkaz:
https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
Autor:
Fabian Pusch, Heathcliff Dorado García, Robin Xu, Dennis Gürgen, Yi Bei, Lotte Brueckner, Claudia Röefzaad, Jennifer von Stebut, Victor Bardinet, Rocío Chamorro González, Angelika Eggert, Johannes H. Schulte, Patrick Hundsdörfer, Georg Seifert, Kerstin Haase, Beat Schaefer, Marco Wachtel, Anja A. Kühl, Michael V. Ortiz, Antje M. Wengner, Monika Scheer, Anton G. Henssen
The small molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), elimusertib, is currently being tested clinically in various cancer entities in adults and children. Its preclinical anti-tumor activity in pediatric malignancies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0d29ac49cc5470dd6d6265d1b65580e
https://doi.org/10.1101/2022.11.10.515290
https://doi.org/10.1101/2022.11.10.515290
Autor:
Anne, Thorwarth, Kerstin, Haase, Claudia, Röefzaad, Kristian W, Pajtler, Kathrin, Schramm, Kathrin, Hauptmann, Anke, Behnke, Christian, Vokuhl, Thomas, Elgeti, Alexander, Gratopp, Johannes H, Schulte, Monika, Scheer, Pablo, Hernáiz Driever, Karsten, Nysom, Angelika, Eggert, Anton G, Henssen, Hedwig E, Deubzer
Publikováno v:
JCO precision oncology. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54f24b9b5c057f3f31a7306de4f1f180
https://pubmed.ncbi.nlm.nih.gov/35613412
https://pubmed.ncbi.nlm.nih.gov/35613412
Autor:
Eric Blanc, Annika Winkler, F Hertwig, Katharina Kasack, Joern Toedling, Filippos Klironomos, Victor Bardinet, Konstantin Helmsauer, Johannes H. Schulte, Anton G. Henssen, Patrick Hundsdörfer, Theresa M Thole, Natalie Timme, Ian C. MacArthur, Richard Koche, David Torrents, Elias Rodriguez-Fos, Nina Thiessen, Claudia Röefzaad, Montserrat Puiggròs, Hedwig E. Deubzer, Jessica Theissen, Karin Schmelz, Dieter Beule, Roland F. Schwarz, Carolina Rosswog, Steffen Fuchs, Rocio Chamorro, Annette Künkele, Angelika Eggert, Heathcliff Dorado Garcia, Sascha Sauer, Martin Burkert, Annabell Szymansky, Jesper L.V. Maag, Natalia Munoz-Perez, Matthias Fischer, Yi Bei
Publikováno v:
Nat Genet
Extrachromosomal circularization of DNA is an important genomic feature in cancer. The structure, composition and genome-wide frequency of extrachromosomal circular DNA, however, have not yet been extensively profiled. Here, we combined genomic and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87775e81c435286f7bad0fc82ccfe777
https://doi.org/10.1038/s41588-019-0547-z
https://doi.org/10.1038/s41588-019-0547-z
Autor:
Konstantin Helmsauer, Matthias Fischer, David Torrents, M. E. Valieva, Philipp Euskirchen, F Hertwig, Katharina Kasack, Claudia Röefzaad, Heathcliff Dorado Garcia, Rocío Chamorro González, Luis P. Kuschel, Robert Schöpflin, Kerstin Haase, Stefan Mundlos, Angelika Eggert, Anton G. Henssen, Verena Heinrich, Yi Bei, Johannes Schulte, Richard Koche, Michael I. Robson, Elias Rodriguez-Fos, Montserrat Puiggròs, Carolina Rosswog, Annabell Szymansky, Salaheddine Ali, Jörn Tödling
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA. The exact amplicon structure has not been described thus far and the functional relevan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9711a48d996498abf07dbc3f6d695
Autor:
Joern Toedling, Victor Bardinet, Angelika Eggert, Carolina Rosswog, Natalia Munoz-Perez, Steffen Fuchs, Anton G. Henssen, Jesper L.V. Maag, Theresa M Thole, Johannes H. Schulte, Dieter Beule, Matthias Fischer, David Torrents, Filippos Klironomos, Heathcliff Dorado Garcia, Hedwig E. Deubzer, Annabell Szymansky, Montserrat Puiggròs, Natalie Timme, Ian C. MacArthur, Eric Blanc, Annika Winkler, Rocio Chamorro, Annette Künkele, F Hertwig, Karin Schmelz, Yi Bei, Roland F. Schwarz, Katharina Kasack, Richard Koche, Martin Burkert, Sascha Sauer, Patrick Hundsdörfer, Elias Rodriguez-Fos, Nina Thiessen, Jessica Theissen, Claudia Röefzaad, Konstantin Helmsauer
Publikováno v:
Nature Genetics. 52:464-464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45bf3ca27715366109c9c9d09122e71
https://doi.org/10.1038/s41588-020-0598-1
https://doi.org/10.1038/s41588-020-0598-1
Autor:
Helmsauer, Konstantin, Valieva, Maria E., Ali, Salaheddine, Chamorro González, Rocío, Rodriguez-Fos, Elias, Puiggròs, Montserrat, Torrents, David
Publikováno v:
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Universitat Politècnica de Catalunya (UPC)
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). The exact amplicon structure has not been described thus far and the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::75cbbd3e2b7e858ca9bd64f81c06706b