Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Claudia Noack"'
Autor:
Claudia Noack, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, Laura Cecilia Zelarayán
Publikováno v:
Stem Cell Research, Vol 23, Iss C, Pp 127-131 (2017)
Krueppel-like factor 15 (KLF15) is abundantly expressed in liver, kidney, and muscle, including myocardium. In the adult heart KLF15 is important to maintain homeostasis and to repress hypertrophic remodeling. We generated a homozygous hESC KLF15 kno
Externí odkaz:
https://doaj.org/article/b3d4ee37248248eeaf0f489e459b5be2
Publikováno v:
Bio-Protocol, Vol 6, Iss 13 (2016)
Fibroblasts are often used as a feeder layer for progenitor or stem cells in co-culture systems. In the heart fibroblasts are important for cardiac development, homeostasis, and remodelling. They provide cardiomyocytes and progenitor cells not only w
Externí odkaz:
https://doaj.org/article/112f012d806d4a3a9d4c1113e89cfe8a
Autor:
Claudia Noack, Maria‐Patapia Zafiriou, Hans‐Joerg Schaeffer, Anke Renger, Elena Pavlova, Rainer Dietz, Wolfram H. Zimmermann, Martin W. Bergmann, Laura C. Zelarayán
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 9, Pp 992-1007 (2012)
Abstract Wnt/β‐catenin signalling controls adult heart remodelling in part via regulation of cardiac progenitor cell (CPC) differentiation. An enhanced understanding of mechanisms controlling CPC biology might facilitate the development of new the
Externí odkaz:
https://doaj.org/article/c43eb5fa41884bf287e16986c246bb44
Autor:
Laura C Zelarayan, Ali El-Armouche, Lavanya M Iyer, Anke Renger, Wolfram-Hubertus Zimmermann, Andreas Jungmann, Claudia Noack, Matthias Dewenter, Franziska S Rathjens, Karl Toischer, Larissa Fabritz, Fahima Syeda, Maria-Patapia Zafeiriou, Alica Blenkle, Oliver J. Müller
Publikováno v:
Cardiovascular Research
Aims Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23405a5a5638ee33855c8e919f42015c
http://europepmc.org/articles/PMC8262635
http://europepmc.org/articles/PMC8262635
Autor:
Wei Tan, Laura C Zelarayan, Claudia Noack, Rhonda Bassel-Duby, Shirin Doroudgar, Julia Groß, Nicole Herzog, Wolfram H. Zimmermann, Ning Liu, Orr Shomroni, John R. McAnally, Kelli J. Carroll, Eric Schoger, Gabriela Salinas, Lavanya M Iyer
Publikováno v:
Circulation Research. 126:6-24
Rationale: Genome editing by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is evolving rapidly. Recently, second-generation CRISPR/Cas9 activation systems based on nuclease inactive dead (d)Cas9 fused to transcriptional tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f2527f1eff6e4f539df68b29e51144
https://doi.org/10.1161/circresaha.118.314522
https://doi.org/10.1161/circresaha.118.314522
Autor:
Wolfram-Hubertus Zimmermann, Laura C Zelarayan, Malte Tiburcy, Dörthe M. Katschinski, Elif Levent, Claudia Noack
Publikováno v:
Circulation. 142(17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69495be0a3cf8bbe3995d3a74b32331
https://pubmed.ncbi.nlm.nih.gov/33104400
https://pubmed.ncbi.nlm.nih.gov/33104400
Autor:
Orr Shomroni, Cheila Rocha, Gabriela Salinas, Laura C Zelarayan, Mareike Jassyk, Eric Schoger, Lavanya M Iyer, Claudia Noack
Publikováno v:
Circulation Research. 127
An altered transcriptomic profile of cardiomyocytes is a hallmark of cardiac remodelling and heart failure. Re-activation of gene programs necessary for myocardial homeostasis and inhibition of deleterious signalling pathways, such as Wnt/beta-cateni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d1a72bdf4956af07779de733ad9277
https://doi.org/10.1161/res.127.suppl_1.498
https://doi.org/10.1161/res.127.suppl_1.498
Autor:
Laura C Zelarayan, Eva Wagner, Wolfram-Hubertus Zimmermann, Enno Klussmann, Norman Y. Liaw, Lavanya M Iyer, Claudia Noack, Kerstin Zuehlke, Eric Schoger
Publikováno v:
Circulation Research. 125
Integrative biochemical and omic-based approaches have refined our understanding of how cells integrate the Wnt signal at the chromatin level to yield specific cellular responses. However, this aspect remains unexplored in the heart. Since Wnt/β-cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79265410c0da0dce2aa3e4c0330e7941
https://doi.org/10.1161/res.125.suppl_1.377
https://doi.org/10.1161/res.125.suppl_1.377
Autor:
John McAnally, Lavanya M Iyer, Eric Schoger, Rhonda Bassel-Duby, Wei Tan, Laura C Zelarayan, Kelli J. Carroll, Claudia Noack, Wolfram H. Zimmermann, Norman Y. Liaw
Publikováno v:
Circulation Research. 125
Cardiac remodelling is accompanied by silencing of genes necessary for cardiac homeostasis including Krüppel-like factor 15 ( Klf15 ), an anti-hypertrophic factor. Due to a lack of tools for gene activation, we aim to adapt a CRISPR-based approach f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8f54e9e7d33385a8d7daf33e9c7a44
https://doi.org/10.1161/res.125.suppl_1.372
https://doi.org/10.1161/res.125.suppl_1.372
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39646411f4101ab3b75b2673ad007224
https://doi.org/10.1096/fasebj.2019.33.1_supplement.758.12
https://doi.org/10.1096/fasebj.2019.33.1_supplement.758.12