Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Claudia N. Generaux"'
Autor:
Mary F. Paine, Dhiren R. Thakker, David W. Boykin, Richard R. Tidwell, Mohamed A. Ismail, Arlene S. Bridges, Claudia N. Generaux, Garrett R. Ainslie
Publikováno v:
Drug Metabolism and Disposition. 41:518-528
DB868 [2,5-bis [5-(N-methoxyamidino)-2-pyridyl] furan], a prodrug of the diamidine DB829 [2,5-bis(5-amidino-2-pyridyl) furan], has demonstrated efficacy in murine models of human African trypanosomiasis. A cross-species evaluation of prodrug bioconve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246cbe7465926ee8114fa052479c62e9
https://doi.org/10.1124/dmd.112.048231
https://doi.org/10.1124/dmd.112.048231
Autor:
Miyoung Yoon, Carol A. Olson, Mary F. Paine, Richard R. Tidwell, James Edwin Hall, Grace Zhixia Yan, Kim L. R. Brouwer, Harvey J. Clewell, Rachel Beaulieu Goldsmith, Claudia N. Generaux
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(1)
Dose selection during antiparasitic drug development in animal models and humans traditionally has relied on correlations between plasma concentrations obtained at or below maximally tolerated doses that are efficacious. The objective of this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437e8a883b5dd5c55a5c45feb3e1a2c9
https://pubmed.ncbi.nlm.nih.gov/21953913
https://pubmed.ncbi.nlm.nih.gov/21953913
Autor:
Mary F, Paine, Michael Zhuo, Wang, Claudia N, Generaux, David W, Boykin, W David, Wilson, Harry P, De Koning, Carol A, Olson, Gabriele, Pohlig, Christian, Burri, Reto, Brun, Grace A, Murilla, John K, Thuita, Michael P, Barrett, Richard R, Tidwell
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 11(8)
Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::218ea05a777c2d996dd0a90e39b4117d
https://pubmed.ncbi.nlm.nih.gov/20721830
https://pubmed.ncbi.nlm.nih.gov/20721830
Autor:
Rachel Beaulieu Goldsmith, Howard M. Reisner, Claudia N. Generaux, Danny R. Gray, Richard R. Tidwell, Zhixia Yan
Publikováno v:
Journal of clinical laboratory analysis. 24(3)
Human African trypanosomiasis (HAT), also called African sleeping sickness, is a neglected tropical parasitic disease indigenous to sub‐Saharan Africa. Diamidine compounds, including pentamidine and CPD‐0801, are potent anti‐trypanosomal molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4af12c2158e6ff2285ba96525f2e7a
https://pubmed.ncbi.nlm.nih.gov/20486201
https://pubmed.ncbi.nlm.nih.gov/20486201
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(3)
Piperacillin metabolism and biliary excretion are different between humans and preclinical species. In the present study, piperacillin metabolites were characterized in bile and urine of healthy humans and compared with metabolites formed in vitro. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2ef046a44eda8648ac260b6b0b284b
https://pubmed.ncbi.nlm.nih.gov/17194717
https://pubmed.ncbi.nlm.nih.gov/17194717
Autor:
James Edwin Hall, Arlene S. Bridges, Reem K. Arafa, David W. Boykin, Claudia N. Generaux, Yi Miao, Tanja Wenzler, Mohamed A. Ismail, W. David Wilson, Reto Brun
Publikováno v:
Journal of medicinal chemistry. 49(17)
Diamidines 10a−g and 18a,b were obtained from dinitriles 9a−g and 15a,b by treatment with lithium trimethylsilylamide or upon hydrogenation of bis-O-acetoxyamidoximes. Dinitriles 9a−g were prepared via Suzuki reactions between arylboronic acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827376b95c5fc2025e0ce258126bae7f
https://pubmed.ncbi.nlm.nih.gov/16913722
https://pubmed.ncbi.nlm.nih.gov/16913722