Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Claudia Mickael"'
Autor:
Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. Graham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal rol
Externí odkaz:
https://doaj.org/article/c4fa6ee4bd3349f19baf5bada146c57a
Autor:
Dara C. Fonseca Balladares, Biruk Kassa, Claudia Mickael, Rahul Kumar, Kevin Nolan, Thais C. F. Menezes, Michael H. Lee, Anthony M. Lau-Xiao, Ari B. Molofsky, Elina Wells, Brian B. Graham
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9202 (2024)
Background: Schistosomiasis is a parasitic infection that can cause pulmonary hypertension (PH). Th2 CD4 T cells are necessary for experimental Schistosoma-PH. However, if T cells migrate to the lung to initiate, the localized inflammation that drive
Externí odkaz:
https://doaj.org/article/69d4f02fe86a45deb56aae1d8f57c07b
Autor:
Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. Stenmark
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHypoxia is a common pathological driver contributing to various forms of pulmonary vascular diseases leading to pulmonary hypertension (PH). Pulmonary interstitial macrophages (IMs) play pivotal roles in immune and vascular dysfunction, l
Externí odkaz:
https://doaj.org/article/ff6beb390653433dbe01318df19ac657
Autor:
Biruk Kassa, Dara C. Fonseca‐Balladares, Rahul Kumar, Michael H. Lee, Claudia Mickael, Linda Sanders, Kevin Nolan, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Whether all Schistosoma species cause pulmonary hypertension (PH) is unclear. Experimentally exposing mice to Schistosoma haematobium eggs caused PH, which was less severe than that induced by S. mansoni exposure. These findings align with t
Externí odkaz:
https://doaj.org/article/46ef8c2b319c48a4b72d155414d53fe3
Autor:
Brian B. Graham, Joan F. Hilton, Michael H. Lee, Rahul Kumar, Dara Fonseca Balladares, Farbod N. Rahaghi, Raúl San José Estépar, Claudia Mickael, Rodrigo Luís Barbosa Lima, Camila M.C. Loureiro, Juliana Lucena, Rudolf K.F. Oliveira, Ricardo de Amorim Corrêa
Publikováno v:
JHLT Open, Vol 1, Iss , Pp 100007- (2023)
Pulmonary arterial hypertension associated with schistosomiasis (SchPAH) and pulmonary arterial hypertension associated with portal hypertension (PoPAH) are lung diseases that develop in the presence of liver diseases. However, mechanistic pathways b
Externí odkaz:
https://doaj.org/article/3299026feb594a1cb3780fc79b26ce21
Autor:
Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Right ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH i
Externí odkaz:
https://doaj.org/article/783929df348a4cba9dd4c63c25ba23b0
Autor:
Biruk Kassa, Michael H Lee, Rahul Kumar, Claudia Mickael, Linda Sanders, Rubin M Tuder, Margaret Mentink-Kane, Brian B Graham
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010343 (2022)
BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-d
Externí odkaz:
https://doaj.org/article/598c70bd548d40a9ac150d51cce361c6
Autor:
Jean Pierre Sibomana, Aloma Campeche, Roberto J. Carvalho-Filho, Ricardo Amorim Correa, Helena Duani, Virginia Pacheco Guimaraes, Joan F. Hilton, Biruk Kassa, Rahul Kumar, Michael H. Lee, Camila M. C. Loureiro, Sula Mazimba, Claudia Mickael, Rudolf K. F. Oliveira, Jaquelina S. Ota-Arakaki, Camila Farnese Rezende, Luciana C. S. Silva, Edford Sinkala, Hanan Yusuf Ahmed, Brian B. Graham
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung bloo
Externí odkaz:
https://doaj.org/article/305f8bf524b54848967de4207fdbe852
Autor:
Rahul Kumar, Michael H. Lee, Claudia Mickael, Biruk Kassa, Qadar Pasha, Rubin Tuder, Brian Graham
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) gains entry into the lung epithelial cells by binding to the surface protein angiotensin-converting enzyme 2. Severe SARS-CoV-2 infection, also known as coronavirus disease 2019 (COVID-19),
Externí odkaz:
https://doaj.org/article/75054e8c4b604736bc42c19e7ce892ee
Autor:
Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffrey C. Robinson, Daniel E. Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Alexandre McKeon, Suzette Riddle, R. Dale Brown, Leslie E. Morgan, Christopher M. Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James P. Maloney, Todd M. Bull, William J. Janssen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that int
Externí odkaz:
https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a