Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Claudia McGinnis"'
Autor:
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187574 (2017)
Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The development of novel ON drug candidates has demonstrated excellent efficacy, but in certain cases
Externí odkaz:
https://doaj.org/article/50e4d29434af416b9fb4beb0c1a70d7a
Autor:
Anna Lenard, Elisa Alghisi, Hamina Daff, Massimiliano Donzelli, Claudia McGinnis, Claudia Lengerke
Publikováno v:
Haematologica, Vol 101, Iss 5 (2016)
Externí odkaz:
https://doaj.org/article/0870ec65cc1f4b7a9a7e99c5b6f34a28
Autor:
Manuela Jaklin, Claudia McGinnis, Erich Kueng, Paul Barrow, Lisa Sach-Peltason, Marcel Leist, Stefan Kustermann, Jitao David Zhang, Nicole Schaefer, Nicole Clemann
Publikováno v:
Toxicological Sciences
Teratogenicity poses severe threats to patient safety. Stem-cell-based in vitro systems are promising tools to predict human teratogenicity. However, current in vitro assays are limited because they either capture effects on a certain germ layer, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb95219af3a197bc5805d486b9c288ab
https://doi.org/10.1101/2021.07.06.451364
https://doi.org/10.1101/2021.07.06.451364
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98383c2302b7e39b205b8db7cce782a
https://doi.org/10.1530/endoabs.73.oc14.2
https://doi.org/10.1530/endoabs.73.oc14.2
Autor:
Claudia McGinnis, Robin Dickinson, Dongtao Lee, Kenneth Macleod, Rachel McBrinn, Larry Higgins
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2feec9526e00c0f9c8cccab368820bd
https://doi.org/10.1530/endoabs.73.aep405
https://doi.org/10.1530/endoabs.73.aep405
Autor:
Katie Turner, Julia Hui, Graeme J. Moffat, Dinesh Stanislaus, Bruce K. Beyer, Scott Engel, Kimberly Brannen, James Vergis, David Potter, Claudia McGinnis, Nicola Powles-Glover, Mary Ellen McNerney, Aaron Fullerton, Karen A. Augustine, Brian P. Enright, Paul Barrow, Michael J. Graziano, William S. Nowland, Marlowe J. Schneidkraut
Publikováno v:
Reproductive Toxicology. 88:17-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3c53e23ffa154d27a79ed315eec7ee
https://doi.org/10.1016/j.reprotox.2019.07.033
https://doi.org/10.1016/j.reprotox.2019.07.033
Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models
Autor:
Kar Lai, Poon, Xingang, Wang, Serene G P, Lee, Ashley S, Ng, Wei Huang, Goh, Zhonghua, Zhao, Muthafar, Al-Haddawi, Haishan, Wang, Sinnakaruppan, Mathavan, Philip W, Ingham, Claudia, McGinnis, Tom J, Carney
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 156(1)
Organ toxicity, particularly liver toxicity, remains one of the major reasons for the termination of drug candidates in the development pipeline as well as withdrawal or restrictions of marketed drugs. A screening-amenable alternative in vivo model s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78ad8241b8ee62d14aea6109580f2155
https://pubmed.ncbi.nlm.nih.gov/28069987
https://pubmed.ncbi.nlm.nih.gov/28069987
Autor:
Stephen Fowler, Thomas J. Carney, Phillip W. Ingham, Xingang Wang, Haishan Wang, Ashley Shu Mei Ng, Claudia McGinnis, Wei Huang Goh, Kar Lai Poon
Publikováno v:
Archives of toxicology. 91(3)
Understanding and predicting whether new drug candidates will be safe in the clinic is a critical hurdle in pharmaceutical development, that relies in part on absorption, distribution, metabolism, excretion and toxicology studies in vivo. Zebrafish i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c390bf8eadadaa65229cf492712a8af3
https://pubmed.ncbi.nlm.nih.gov/27485346
https://pubmed.ncbi.nlm.nih.gov/27485346
Autor:
Thomas H. Marsilje, Alan Collis, Dejan Bojanic, Maria Magnifico, Madhu S. Mondal, Philip Bentley, Claudia Mcginnis, Scott A. Biller, Wilfried Frieauff, Hans-Joerg Martus, Willi Suter, Laszlo Urban, Joseph Gabriels
Publikováno v:
Toxicological Sciences. 118:71-85
This article describes the first step toward full (that includes conditions for both absence and presence of metabolic activation) validation and drug discovery application of a 96-well, automated, high-content micronucleus (HCMN) assay. The current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c27036df218e53ef61a7f044ee92cb
https://doi.org/10.1093/toxsci/kfq181
https://doi.org/10.1093/toxsci/kfq181
Autor:
E. Durr, C. Zihlmann, Mohammed Ullah, E. Di Lenarda, N. Schaub, Stefan Kustermann, Adrian Roth, Andreas Brink, Silke Simon, Thomas Singer, Volkmar Starke, Christoph Funk, Franziska Boess, Y.M. Siegrist, Claudia McGinnis, Stephen Fowler, Rubén Alvarez-Sánchez, Kuresh Youdim, R. Lieven, X. Ang, Franz Schuler, Anne-Christine Cascais, Simone Schadt, Michaela Marschmann
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 30(1 Pt)
Drug-induced liver injury (DILI) is a leading cause of acute hepatic failure and a major reason for market withdrawal of drugs. Idiosyncratic DILI is multifactorial, with unclear dose-dependency and poor predictability since the underlying patient-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bc2419c5c5dbfcdf6f3d4ea009394e
https://pubmed.ncbi.nlm.nih.gov/26407524
https://pubmed.ncbi.nlm.nih.gov/26407524