Výsledky vyhledávání - "Claudia Mara Maciel-Rezende"

An in silico Study of Benzophenone Derivatives as Potential Non-Competitive Inhibitors of Trypanosoma cruzi and Leishmania Amazonensis Cysteine Proteinases

Autor: Cláudio Viegas Junior, Letícia de Almeida, Marcelo Henrique dos Santos, Thiago Elias Castilho, Marcos José Marques, Luciano T. Costa, Poliany G. Freitas, Claudia Mara Maciel-Rezende, Nelson José Freitas da Silveira

Publikováno v: Journal of the Brazilian Chemical Society v.29 n.3 2018
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 29, Issue: 3, Pages: 515-527, Published: MAR 2018

This study investigates the mechanisms of interaction between benzophenone derivatives and cruzain and Llacys1 (the protein expressed by cysteine protease gene isoform 1 of L. amazonensis) by homology modelling, docking and molecular dynamics simulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fae45c6a58c860453ad69c36d66f2cb
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000300515

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Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones

Autor: Marcos José Marques, Éderson D’Martin Costa, Antonio C. Doriguetto, Letícia de Almeida, Marcelo Henrique dos Santos, Danielle Ferreira Dias, Claudia Mara Maciel-Rezende, Karina Ferreira Alves, Cláudio Viegas Junior, Francieli Ribeiro Pires

Publikováno v: Bioorganic & Medicinal Chemistry. 21:3114-3119

Nine O -alkyl and O- prenyl derivatives were synthesized from commercial 2,4-dihydroxybenzophenone, 4,e4,4′-dihydroxybenzophenone and were evaluated for their leishmanicidal activity against promastigote forms of Leishmania amazonensis , as well th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8371cdc41757cf5bf0c2446a2a111029
https://doi.org/10.1016/j.bmc.2013.03.045

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Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes

Autor: Cláudio Viegas Junior, Larissa de Oliveira Passos Jesus, Letícia de Almeida, Wagner Alves de Souza Judice, Marcos José Marques, Francieli Ribeiro Pires, Karina Ferreira Alves, Mario Augusto Izidoro, Marcelo Henrique dos Santos, Claudia Mara Maciel-Rezende

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 75

The leishmanicidal potential of benzophenones has been described, some of them highlighting their potential as cysteine protease inhibitors. Therefore, this work described leishmanicidal activity of nine benzophenone derivatives (1a-c;2a-c;3a-c) agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9d1aac8cce5fbdf0b2b0f89d335233
https://pubmed.ncbi.nlm.nih.gov/26463637

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