Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Claudia M. Gohr"'
Publikováno v:
Current Rheumatology Reports. 24:40-45
Arthritis is a common clinical manifestation of hereditary hemochromatosis (HH), and HH is one of a handful of conditions linked to calcium pyrophosphate deposition (CPPD) in joints. The connection between these two types of arthritis has not yet bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c63787f57effab743ff044e29f5cd3
https://doi.org/10.1007/s11926-022-01054-w
https://doi.org/10.1007/s11926-022-01054-w
Autor:
Elizabeth Mitton-Fitzgerald, Ann K. Rosenthal, Amaryllis Ortiz, Charlene J. Williams, Claudia M. Gohr, Gabriel Mbalaviele
Publikováno v:
Arthritis Rheumatol
OBJECTIVE The gene TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate deposition disease (CPDD). While the CCAL1 OPG mutation (OPG-XL) was originally believed to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa62c53564d8edb2d9e75957dd9d719
https://doi.org/10.1002/art.41678
https://doi.org/10.1002/art.41678
Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease
Autor:
L. Cardinal, A. Ortiz, A. Charniak, Ann K. Rosenthal, U. Qazi, Charlene J. Williams, Elizabeth Mitton-Fitzgerald, A.T. Kaell, Claudia M. Gohr, M. Bernstein
Summary Objective Mutations on chromosomes 5p (CCAL2) and 8q (CCAL1) have been linked to familial forms of calcium pyrophosphate deposition disease (CPDD). Mutations in the ANKH gene account for CCAL2, but the identity of CCAL1 has been elusive. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fe789b80fb11f1c479a2fd505e5658
https://europepmc.org/articles/PMC6293976/
https://europepmc.org/articles/PMC6293976/
Publikováno v:
Current rheumatology reports. 18(5)
The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50225bb3a97e346287189d0ca6db8753
https://pubmed.ncbi.nlm.nih.gov/27032788
https://pubmed.ncbi.nlm.nih.gov/27032788
Publikováno v:
Biochemical and Biophysical Research Communications. 388:533-538
Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c23909a0f4efc657c09b54c15444f1a
https://doi.org/10.1016/j.bbrc.2009.08.038
https://doi.org/10.1016/j.bbrc.2009.08.038
Publikováno v:
Osteoarthritis and Cartilage. 16(11):1395-1402
Summary Objective Sixty percent of synovial fluids from patients with severe osteoarthritis (OA) contain calcium pyrophosphate dihydrate (CPPD) or basic calcium phosphate (BCP) crystals. These bioactive crystals can be particularly difficult to accur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b901b3e37f6b3c1c00d1873ed0f5a228
Publikováno v:
Connective Tissue Research. 48:286-291
Calcific tendonitis is a common clinical condition associated with high rates of tendon rupture, prolonged symptoms, and poor response to therapy. Little is known about the pathogenesis of calcifications in tendons and consequently few effective ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28fca14df9f0ebc0571cefdff31dcf6
https://doi.org/10.1080/03008200701692362
https://doi.org/10.1080/03008200701692362
Autor:
James T. Ninomiya, Carolyn B. Coyne, Ann K. Rosenthal, Elizabeth Mitton-Fitzgerald, Claudia M. Gohr, Rupinder Grewal, William T. Jackson
Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58873ba7d2cc62d575c2ee6d80268f8d
https://europepmc.org/articles/PMC4505557/
https://europepmc.org/articles/PMC4505557/
Publikováno v:
Osteoarthritis and Cartilage. 11(6):463-470
Objectives : Thyroid hormones induce features of the hypertrophic phenotype in mature articular chondrocytes as well as in growth plate chondrocytes. Hypertrophic chondrocytes are responsible for extracellular matrix mineralization, with formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee1b8194c362d1b8d76bc8f05ac11c9
Publikováno v:
Osteoarthritis and Cartilage. 9(6):578-581
Objectives The transglutaminase (TGase) family includes seven different enzymes that catalyse a protein cross-linking reaction resulting in structural and functional alterations in substrate proteins. TGase activity is easily measureable in mature ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7af35b10cf4d3baa08b1d6b57fa959a