Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Claudia M. Calvet"'
Autor:
Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust, Adam R. Renslo
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 15-25 (2013)
Inhibition of the Trypanosoma cruzi cysteine protease cruzain has been proposed as a therapeutic approach for the treatment of Chagas’ disease. Among the best-studied cruzain inhibitors to date is the vinylsulfone K777 (1), which has proven effecti
Externí odkaz:
https://doaj.org/article/e62bfad262f447a899c4489a4219fb1f
Autor:
Anjan Debnath, Claudia M Calvet, Gareth Jennings, Wenxu Zhou, Alexander Aksenov, Madeline R Luth, Ruben Abagyan, W David Nes, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006104 (2017)
Primary Amoebic Meningoencephalitis (PAM) is caused by Naegleria fowleri, a free-living amoeba that occasionally infects humans. While considered "rare" (but likely underreported) the high mortality rate and lack of established success in treatment m
Externí odkaz:
https://doaj.org/article/553d08f0e7b9437eabf9c8b31e039082
Autor:
Julia Medeiros Souza, Everton M Silva, Jessey Erath, Diane Thomas, James H. McKerrow, Lori Ferrins, Baljinder Singh, Erica Penn, Robert F. Campbell, Jair L. Siqueira-Neto, Ana Rodriguez, Jean A. Bernatchez, Susan E. Leed, Norma Roncal, Hitesh B. Jalani, Jasmin Ackermann, Michael P. Pollastri, Dana M. Klug, Laura-Isobel McCall, Kelly A. Bachovchin, Claudia M. Calvet, Richard J. Sciotti, Seema Bag, Melissa J. Buskes
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites includin
Autor:
Saulo Cabral Bourguignon, Mirian Claudia de Souza Pereira, Guilherme C. Lechuga, Carlos José Brito Ramos, Juliana Coelho Rodrigues Lima, Claudia M. Calvet, Valéria Laneuville Teixeira
Publikováno v:
Revista Brasileira de Farmacognosia, Vol 29, Iss 6, Pp 735-738 (2019)
Revista Brasileira de Farmacognosia v.29 n.6 2019
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Revista Brasileira de Farmacognosia v.29 n.6 2019
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Various extracts obtained from the red alga Plocamium brasiliense (Greville Howe & Taylor), including a fraction containing crude 5-chloro-1-(E)-chlorovinyl-2,4-dibromo-1,5-dimethylcyclohexane (1) and another containing a mixture of halogenated monot
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Autor:
Roberto Cirilli, Daniela De Vita, Marcel Kaiser, Antonella Messore, Valentina Noemi Madia, Cristina Faggi, Claudia M. Calvet, Vincenzo Summa, Annalise Di Marco, Gareth K. Jennings, Larissa M. Podust, Alessandro De Leo, Roberta Costi, Roberto Di Santo, Luca Pescatori, Valeria Tudino, Pascal Mäser, Reto Brun, Francesco Saccoliti, Luigi Scipione, Giacomo Pepe, Maria Rosaria Battista
Publikováno v:
Journal of Medicinal Chemistry. 62:1330-1347
We have designed and synthesized a series of new imidazole-based compounds structurally related to an antiprotozoal agent with nanomolar activity which we identified recently. The new analogues possess micromolar activities against Trypanosoma brucei
Autor:
James H. McKerrow, Tatiana Araújo Silva, Claudia M. Calvet, Jair L. Siqueira-Neto, Diane Thomas, David Gonzalez, Jacob M. Wozniak
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0007980 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in
Autor:
Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1736 (2012)
BACKGROUND:Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due
Externí odkaz:
https://doaj.org/article/0fedffa603054e8faa798a38e8ca4f82
Autor:
Luis Felipe de Carvalho Ferreira, Claudia M. Calvet, Tatiana Araújo Silva, Mirian Claudia de Souza Pereira
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4836 (2019)
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4836 (2019)
Transforming growth factor beta (TGF-&beta
) is a determinant for inflammation and fibrosis in cardiac and skeletal muscle in Chagas disease. To determine its regulatory mechanisms, we investigated the response of Trypanosoma cruzi-infected card
) is a determinant for inflammation and fibrosis in cardiac and skeletal muscle in Chagas disease. To determine its regulatory mechanisms, we investigated the response of Trypanosoma cruzi-infected card
Autor:
Mirian Claudia de Souza Pereira, Lygia da Veiga Pereira, Juliana Borsoi, Claudia M. Calvet, Thabata Lopes Alberto Duque, Andrea Henriques-Pons, Leonardo da Silva Lara, Leonardo C. Andrade-Lima
Publikováno v:
Microbes and Infection. 20:312-316
Chagas disease, caused by Trypanosoma cruzi, is an important global public health problem which, despite partial efficacy of benznidazole (Bz) in acute phase, urgently needs an effective treatment. Cardiotoxicity is a major safety concern for conduct