Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Claudia M Testa"'
Autor:
Lana Sargent, Nitai D. Mukhopadhyay, Elvin T. Price, Leslie J. Cloud, Mark S. Baron, Jon D Snider, Brian Berman, Helengrace Quilon, Huma Nawaz, Sarah K. Lageman, Kristin M Zimmerman, Claudia M. Testa, Matthew J. Barrett
Publikováno v:
J Parkinsons Dis
Background: Individuals with Parkinson’s disease (PD) may be especially vulnerable to future cognitive decline from anticholinergic medications. Objective: To characterize anticholinergic medication burden, determine the co-occurrence of anticholin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca51fe24d227d68452efbfb72baefec1
https://doi.org/10.3233/jpd-212769
https://doi.org/10.3233/jpd-212769
Autor:
Claudia M. Testa
Publikováno v:
Current Geriatrics Reports. 11:19-32
Expanding therapeutic targets from proteins to RNAs opens up new possibilities for neurodegenerative disorders therapeutics development. Recently, a disease-modifying antisense oligonucleotide (ASO) agent was approved for spinal muscular atrophy, sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580b5eb3404706051431c67530be2bd1
https://doi.org/10.1007/s13670-020-00341-7
https://doi.org/10.1007/s13670-020-00341-7
Autor:
Florence C.F. Chang, Mark S. LeDoux, Victor S.C. Fung, Scott A. Norris, Christine Klein, Hyder A. Jinnah, Irene A. Malaty, Brian Berman, Joseph Jankovic, Emmanuel Roze, Sebastian Loens, Richard L. Barbano, Joel S. Perlmutter, Alberto J. Espay, Claudia M. Testa, Marie Vidailhet, Tobias Bäumer, Abhimanyu Mahajan, Laura J. Wright, Avinash V. Murthy
Publikováno v:
Mov Disord
BACKGROUND Knowledge of characteristics in upper limb dystonia remains limited, derived primarily from small, single-site studies. OBJECTIVE The objective of this study was to characterize demographic and clinical characteristics of upper limb dyston
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b930b56bb98af5aed217401abf2bc2
https://doi.org/10.1002/mds.28223
https://doi.org/10.1002/mds.28223
Autor:
Anthony W S Chan, Jie Jiang, Yiju Chen, Chunxia Li, Melinda S Prucha, Yijuan Hu, Tim Chi, Sean Moran, Tayeb Rahim, Shihua Li, Xiaojiang Li, Stuart M Zola, Claudia M Testa, Hui Mao, Rosa Villalba, Yoland Smith, Xiaodong Zhang, Jocelyne Bachevalier
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses co
Externí odkaz:
https://doaj.org/article/e416b6c611374cee97ca7a70bf7d021c
Autor:
Teresa Srajer, Francisco Cardoso, Ralf Reilmann, Asuncion Martinez, Julie C. Stout, Elizabeth McCusker, Claudia M. Testa, Zhong Pei, Bernhard Landwehrmeyer, Christopher A. Ross, Jamie Levey, Blair R. Leavitt, Sarah J. Tabrizi, Jee Bang
Publikováno v:
Movement Disorders Clinical Practice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bce9011edbb1d50e908f63f86dad802
https://doi.org/10.1002/mdc3.12808
https://doi.org/10.1002/mdc3.12808
Autor:
Claudia M. Testa
Publikováno v:
Tremor and Other Hyperkinetic Movements, Vol 3 (2013)
Genetics research is an avenue towards understanding essential tremor (ET). Advances have been made in genetic linkage and association: there are three reported ET susceptibility loci, and mixed but growing data on risk associations. However, causal
Externí odkaz:
https://doaj.org/article/10a3b532f06d475e923300902175c837
Evaluation of the Safety of Deutetrabenazine at Higher Doses to Treat Chorea in Huntington’s Disease
Autor:
Mark Forrest Gordon, David Oakes, Elise Kayson, Juha-Matti Savola, Nicholas Gross, Mat D. Davis, Jacquelyn Whaley, Maria Wieman, Samuel Frank, Claudia M. Testa, Shirley Eberly, Christina Vaughan, Jody Goldstein, David Stamler
Publikováno v:
CNS Spectrums. 26:162-163
BackgroundIn the First-HD pivotal trial, the maximum deutetrabenazine dose evaluated to treat chorea associated with Huntington’s disease (HD chorea) was 48 mg/d, which is the approved maximum dose for this population. In ARC-HD, an open-label exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153786e18f6d851621dcebf5e0f11539
https://doi.org/10.1017/s1092852920002618
https://doi.org/10.1017/s1092852920002618
Autor:
David Oakes, Samuel Frank, Jody Goldstein, Mat D. Davis, David Stamler, Christina Vaughan, Jacquelyn Whaley, Claudia M. Testa, Mark Forrest Gordon, Elise Kayson, Juha-Matti Savola
Publikováno v:
CNS Spectrums. 26:164-165
BackgroundChorea is a prominent motor dysfunction in Huntington’s disease (HD). Deutetrabenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor, is FDA-approved for the treatment of chorea in HD. In the pivotal, 12-week First-HD trial, deut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07132bae31fd5e85591b2f95501346b4
https://doi.org/10.1017/s1092852920002655
https://doi.org/10.1017/s1092852920002655
Autor:
Michel Panisset, Günther Deuschl, Patrick A. Dion, Lukas Tittmann, Mark Hallett, Claudia M. Testa, Simon Girard, Zbigniew K. Wszolek, Karin Srulijes, Klaus Seppi, Susanne A. Schneider, Gregor Kuhlenbäumer, Nancy D. Merner, Juliane Winkelmann, Wolfgang Lieb, Manuela Pendziwiat, Dietrich Haubenberger, Oswaldo Lorenzo-Betancor, Franziska Hopfner, Ronald B. Postuma, Kirsten E. Zeuner, Geneviève Bernard, Sylvain Chouinard, Guy A. Rouleau, Elan D. Louis, Owen A. Ross, Eva Reischl, Thomas Arzberger, Daniela Berg, Stefanie H. Müller, Sara Ortega-Cubero, Cynthia V. Bourassa, Joshua M. Shulman, Ali H. Rajput, Alexandra I. Soto-Ortolaza, Stephan Klebe, Nicolas Dupré, Isabel Wurster, Pau Pastor, Anna Hussl, Konstantin Strauch, Karl-Heinz Ladwig, Colin A. Hodgkinson, Joseph Jankovic, Delia Lorenz, Werner Poewe, Lorraine N. Clark, Alex Rajput, Carles Vilariño-Güell
Publikováno v:
Brain 139, 3163-3169 (2016)
Brain 139(12), 3163-3169 (2016). doi:10.1093/brain/aww242
Brain 139(12), 3163-3169 (2016). doi:10.1093/brain/aww242
We conducted a genome-wide association study of essential tremor, a common movement disorder characterized mainly by a postural and kinetic tremor of the upper extremities. Twin and family history studies show a high heritability for essential tremor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f6a8d91674448e5d174db466b050ff
https://doi.org/10.1093/brain/aww242
https://doi.org/10.1093/brain/aww242
Autor:
Alfredo Berardelli, Brian Berman, Ami Rosen, Ramon L. Rodriguez, Alberto J. Espay, Stephen G. Reich, Irene A. Malaty, Florence Ching Fen Cheng, Hyder A. Jinnah, Ludy C. Shih, Emmanuel Roze, Susan H. Fox, Christine Klein, Marie Vidailhet, William G. Ondo, Sarah Pirio Richardson, Tao Xie, Joel S. Perlmutter, Mark Hallett, Pinky Agarwal, Scott A. Norris, Laura J. Wright, Norbert Brüggemann, Daniel D. Truong, Mark S. LeDoux, Fatta B. Nahab, Claudia M. Testa, Zoltan Mari, Richard L. Barbano
Publikováno v:
Movement Disorders. 31:1874-1882
Background Clinical characteristics of isolated idiopathic cervical dystonia such as onset site and spread to and from additional body regions have been addressed in single-site studies with limited data and incomplete or variable dissociation of foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::103a14d97ace5f84d2c056f7cc99f32c
https://doi.org/10.1002/mds.26817
https://doi.org/10.1002/mds.26817