The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

Autor: Beatriz Alvarez-Castelao, Susanne tom Dieck, Claudia M Fusco, Paul Donlin-Asp, Julio D Perez, Erin M Schuman

Publikováno v: eLife, Vol 9 (2020)

We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nasc

Externí odkaz: https://doaj.org/article/a2a91b9d6fb5494ea948d96533c2e08d

Co-translational assembly orchestrates competing biogenesis pathways

Autor: Maximilian Seidel, Anja Becker, Filipa Pereira, Jonathan J. M. Landry, Nayara Trevisan Doimo de Azevedo, Claudia M. Fusco, Eva Kaindl, Natalie Romanov, Janina Baumbach, Julian D. Langer, Erin M. Schuman, Kiran Raosaheb Patil, Gerhard Hummer, Vladimir Benes, Martin Beck

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The biogenesis of nuclear pores imposes a logistic challenge for cells. Here, the authors investigate structural motifs for co-translational interactions in nucleoporins and find that co-translational assembly events differ between paralogous assembl

Externí odkaz: https://doaj.org/article/11fbfd960c6d41eaa79ad6eccdf62d07

A Functional Dissection of the mRNA and Locally Synthesized Protein Population in Neuronal Dendrites and Axons

Autor: Julio D Perez, Erin M. Schuman, Claudia M Fusco

Publikováno v: Annu. Rev. Genet.

Neurons are characterized by a complex morphology that enables the generation of subcellular compartments with unique biochemical and biophysical properties, such as dendrites, axons, and synapses. To sustain these different compartments and carry a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd4070f813afa60962b7ef3d40443cf
https://pubmed.ncbi.nlm.nih.gov/34460296

Co-translational assembly counteracts promiscuous interactions

Autor: Benes, Julian David Langer, Claudia M Fusco, Kiran Raosaheb Patil, Jan Baumbach, Erin M. Schuman, Michael Seidel, Annette Becker, Trevisan Doimo de Azevedo N, Martin Beck, Filipa Pereira, Jonathan J M Landry, Kaindl E, Gerhard Hummer

During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::752f4739c302b0196f131b68969cd3ca
https://doi.org/10.1101/2021.07.13.452229

Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins

Autor: Anja Staab, Veronica Villeri, Kristina Desch, Erin M. Schuman, Claudia M Fusco, Julian David Langer, Ivy C. W. Chan, Aline Ricarda Dörrbaum, Mantian Wang, Eleanor Vail

Publikováno v: Nature Communications 12(1), 6127 (2021). doi:10.1038/s41467-021-26365-x
Nat. Commun.
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications (Nat Commun)

Owing to their morphological complexity and dense network connections, neurons modify their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue enriched for dendrites and axons). Although ribosome biogenesis largely takes pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f206c9f7b50af8d77a0776937533f806
https://pub.dzne.de/record/162680