Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Claudia LANGLAIS"'
Autor:
Ania Wilczynska, Sarah L. Gillen, Tobias Schmidt, Hedda A. Meijer, Rebekah Jukes-Jones, Claudia Langlais, Kari Kopra, Wei-Ting Lu, Jack D. Godfrey, Benjamin R. Hawley, Kelly Hodge, Sara Zanivan, Kelvin Cain, John Le Quesne, Martin Bushell
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract Background Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not full
Externí odkaz:
https://doaj.org/article/7d0c484dc2a4472ab9ac49baaa014cd9
Autor:
Andrew Craxton, Deeksha Munnur, Rebekah Jukes-Jones, George Skalka, Claudia Langlais, Kelvin Cain, Michal Malewicz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.
Externí odkaz:
https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b1
Autor:
Alexa Wentges, Alexandra Mack, Josip Skoko, M. Eugenia Delgado, Cathrin Hagenlocher, David Dinsdale, Lydia Dyck, Markus Rehm, Christian T. Hellwig, Carol Hanna, Claudia Langlais, Kelvin Cain, Marion MacFarlane
Publikováno v:
Cell Death and Differentiation
Cancer cells that are resistant to Bax/Bak-dependent intrinsic apoptosis can be eliminated by proteasome inhibition. Here, we show that proteasome inhibition induces the formation of high molecular weight platforms in the cytosol that serve to activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332c998bc32744c429758eb2b423ab05
https://doi.org/10.1038/s41418-021-00843-7
https://doi.org/10.1038/s41418-021-00843-7
Autor:
Tobias Schmidt, Kelvin Cain, Cornelia H. de Moor, Sarah L. Gillen, Ania Wilczynska, Hedda A. Meijer, Rebekah Jukes-Jones, Martin Bushell, Claudia Langlais
Publikováno v:
Nucleic Acids Research
The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b79a3e01f2b095f122af8b1daa6c4e
http://europepmc.org/articles/PMC6736043
http://europepmc.org/articles/PMC6736043
Autor:
Claudia Langlais, Benjamin R. Hawley, Sara Zanivan, Sarah L. Gillen, Martin Bushell, Tobias Schmidt, Jack D. Godfrey, Kelvin Cain, John Le Quesne, Wei-Ting Lu, Hedda A. Meijer, Kari Kopra, Ania Wilczynska, Kelly Hodge, Rebekah Jukes-Jones
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Genome Biology
Genome Biology
BackgroundRegulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444add359bf08aaa4839f1802dab73fb
https://eprints.gla.ac.uk/199869/1/199869.pdf
https://eprints.gla.ac.uk/199869/1/199869.pdf
Publikováno v:
Methods. 61:98-104
Apoptosis and necroptosis are dependent on the formation/activation of distinct multi-protein complexes; these include the Death-Inducing Signalling Complex (DISC), apoptosome, piddosome, necrosome and ripoptosome. Despite intense research, the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6674058109749c78bc5aee7c52301bbc
https://doi.org/10.1016/j.ymeth.2013.02.006
https://doi.org/10.1016/j.ymeth.2013.02.006
Autor:
Peter Geserick, Mike Hupe, Martin Leverkus, Diana Panayotova Dimitrova, Claudia Langlais, Maria Feoktistova, Beate Kellert, Marion MacFarlane, Kelvin Cain, Georg Häcker
Publikováno v:
Molecular Cell. 43:449-463
Summary The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the spontaneous formation of an intracellular platform that activates either apoptosis or necroptosis. This 2 MDa intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ce3fe364b72ec53de8edbfad41efc7
https://doi.org/10.1016/j.molcel.2011.06.011
https://doi.org/10.1016/j.molcel.2011.06.011
Autor:
Thomas E. DeCoursey, Martin J. S. Dyer, Tom Henley, Mahmood Khan, Randy D. Gascoyne, Ian C. M. MacLennan, Mandeep K Bhamrah, Kelvin Cain, Karen Pulford, Claudia Langlais, David Dinsdale, Melania Capasso, Robert S. Boyd, Elena Vigorito, Deri Morgan, Boris Musset, Vladimir V. Cherny
Publikováno v:
Nature Immunology. 11:265-272
Voltage-gated proton currents regulate generation of reactive oxygen species (ROS) in phagocytic cells. In B cells, stimulation of the B cell antigen receptor (BCR) results in the production of ROS that participate in B cell activation, but the invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df14f3769c0058f0906d987160031393
https://doi.org/10.1038/ni.1843
https://doi.org/10.1038/ni.1843
Publikováno v:
Cold Spring Harbor protocols. 2015(12)
This protocol describes an in vitro model for studying the mechanisms of caspase activation and native apoptosome complex assembly in cell-free extracts. Active caspases in dATP-activated lysates are detected by fluorimetry using a tetrapeptide subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba9579c025cec997a95f3db9bcffa49
https://pubmed.ncbi.nlm.nih.gov/26631121
https://pubmed.ncbi.nlm.nih.gov/26631121
Publikováno v:
Journal of Biological Chemistry. 276:41985-41990
In many forms of apoptosis, cytochrome c released from mitochondria induces the oligomerization of Apaf-1 to form a caspase-activating apoptosome complex. Activation of lysates in vitro with dATP and cytochrome c results in the formation of an active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bfb7d66cf5f9326a733dacf39ae42c
https://doi.org/10.1074/jbc.m107419200
https://doi.org/10.1074/jbc.m107419200