Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Claudia Kunz"'
Publikováno v:
Pharmaceutics, Vol 11, Iss 4, p 152 (2019)
The protein therapeutic and CD95L inhibitor asunercept is currently under clinical investigation for the treatment of glioblastoma and myelodysplastic syndrome. The purpose of this study was to predict the asunercept pharmacokinetics in children and
Externí odkaz:
https://doaj.org/article/a2a8789986a24fd6ae8c6155359b23ca
Autor:
Dieter Lemke, Wolfgang Wick, Harald Fricke, Michael Platten, Michael Kluge, Martin Bendszus, Claudia Kunz, Christian Gieffers, Jürgen Debus, Amir Abdollahi, Uwe Haberkorn, Manfred Jugold, Christian Merz, Benedikt Wiestler, Andreas von Deimling, Jaromir Sykora, Torsten Schmenger, Theresa Bunse, Antje Wick, Felix Sahm, Petra Rübmann, Philipp-Niclas Pfenning, Carina M. Thomé, Jonas Blaes
Supplementary Figure 1: Detection of asunercept/ APG101 in brains of treated mice. Supplementary Figure 2: qPCR for MMP2 (A) or MMP9 (B) and representative images of human microglia after 12 h treatment with vehicle (I), 20 µg/ml APG101 (II), 50 U/m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dd0115f80e90f8b03640535eda7b58
https://doi.org/10.1158/1541-7786.22513288
https://doi.org/10.1158/1541-7786.22513288
Autor:
Stephanie E. Combs, Martin Bendszus, Michael Platten, Claudia Kunz, Christian Hartmann, Jürgen Debus, Inga Harting, Elena Vetlova, Josef Pichler, Andreas von Deimling, Maximilian G. Schliesser, Benedikt Wiestler, Oliver Heese, Tobias Martens, Grigory Kobyakov, Klaus Junge, Harald Fricke, Wolfgang Wick
Purpose: Preclinical data indicate anti-invasive activity of APG101, a CD95 ligand (CD95L)–binding fusion protein, in glioblastoma.Experimental Design: Patients (N = 91) with glioblastoma at first or second progression were randomized 1:2 between s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c615c3e083cd6ca127f672e942b84ee
https://doi.org/10.1158/1078-0432.c.6523403
https://doi.org/10.1158/1078-0432.c.6523403
Autor:
Stephanie E. Combs, Martin Bendszus, Michael Platten, Claudia Kunz, Christian Hartmann, Jürgen Debus, Inga Harting, Elena Vetlova, Josef Pichler, Andreas von Deimling, Maximilian G. Schliesser, Benedikt Wiestler, Oliver Heese, Tobias Martens, Grigory Kobyakov, Klaus Junge, Harald Fricke, Wolfgang Wick
Acknowledgement. List of investigators and other study stuff at the individual sites.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91edbf9535d17c28a5448c6c54946b3f
https://doi.org/10.1158/1078-0432.22456733
https://doi.org/10.1158/1078-0432.22456733
Autor:
Stephanie E. Combs, Martin Bendszus, Michael Platten, Claudia Kunz, Christian Hartmann, Jürgen Debus, Inga Harting, Elena Vetlova, Josef Pichler, Andreas von Deimling, Maximilian G. Schliesser, Benedikt Wiestler, Oliver Heese, Tobias Martens, Grigory Kobyakov, Klaus Junge, Harald Fricke, Wolfgang Wick
CONSORT Statement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5521b5e95be5e7b97bf78eb10ef0ac1b
https://doi.org/10.1158/1078-0432.22456730.v1
https://doi.org/10.1158/1078-0432.22456730.v1
Autor:
Stephanie E. Combs, Martin Bendszus, Michael Platten, Claudia Kunz, Christian Hartmann, Jürgen Debus, Inga Harting, Elena Vetlova, Josef Pichler, Andreas von Deimling, Maximilian G. Schliesser, Benedikt Wiestler, Oliver Heese, Tobias Martens, Grigory Kobyakov, Klaus Junge, Harald Fricke, Wolfgang Wick
Suppl Figures S1-S4. S1: Genomic Localization of the CpG2 in the CD95 L promoter. S2: Survival probability according to CpG2 methylation status. S3: Survival probability according to CD95L expression as detected by IHC. S4 a and b: Cox regression dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3416fd1a2322699fc3084de9c15d55c1
https://doi.org/10.1158/1078-0432.22456727.v1
https://doi.org/10.1158/1078-0432.22456727.v1
Autor:
Hans-Jürgen Stellbrink, Torsten Schaller, Kerstin Sturm, Norbert Hermann Brockmeyer, Anja Potthoff, Markus Bickel, Stefan Scholten, Nils Postel, Arne Jessen, Matthias Christian Müller, Dirk Jaeger, Christian Müller, Narges Seyfizadeh, Leonie Jenner, Kevin Moog, Stefan Hans Schöffel, Bernd Ullrich, Laura Brosi, Claudia Kunz, Daniel Thomas, Rico Laage, Frank Hanakam, Oliver Schoenborn-Kellenberger, Marina Mangold, Katharina Och, Thorsten Lehr, Michaela Anja Elisabeth Arndt, Jürgen Krauss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0050342137fe2d7ab0b999b466f8c0b
https://doi.org/10.2139/ssrn.4453382
https://doi.org/10.2139/ssrn.4453382
Autor:
Ulrike Grittner, Matthias Endres, Karl Georg Haeusler, Johannes Schurig, Georg Hagemann, Peter U Heuschmann, Darius G Nabavi, Claudia Kunze, Ingo Schmehl, Robert Stingele, Serdar Tütüncü, Andreas Kauert, Manuel C Olma, Katrin Hansen, Joanna Dietzel, Boris Dimitrijeski, Frank Hamilton, Martin Honermann, Gerhard Jan Jungehuelsing, Hans-Christian Koennecke, Bruno-Marcel Mackert, Paul Sparenberg, Enrico Voelzke, Carolin Waldschmidt, Daniel Zeise-Wehry
Publikováno v:
Open Heart, Vol 11, Iss 2 (2024)
Background Oral anticoagulation (OAC) is key in stroke prevention in patients with atrial fibrillation (AF) but there is uncertainty regarding the optimal timing of OAC (re)initiation after stroke, as recent large randomised controlled trials have me
Externí odkaz:
https://doaj.org/article/670206ec4bbc4bbebf3348b4b2ce2e5d
Publikováno v:
Journal of Pharmaceutical Sciences. 108:399-415
The use of co-solvent systems can benefit the freeze-drying process and product performance. In this study, cycle designs were applied based on existing recommendations for water-based formulations. Modifications thereof and the influence on the proc
Autor:
Claudia Kunz, Henning Gieseler
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2179-2191
The goal of the present study was to assess the applicability of dynamic vapor sorption analysis of freeze-dried products. Water vapor sorption profiles of intact and ground cakes were recorded to determine the relevance of powder handling. Grinding