Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Claudia Knothe"'
Autor:
Dirk van Lier, Adrien Picod, Gernot Marx, Pierre-François Laterre, Oliver Hartmann, Claudia Knothe, Feriel Azibani, Joachim Struck, Karine Santos, Jens Zimmerman, Andreas Bergmann, Alexandre Mebazaa, Peter Pickkers
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
PurposeAdrecizumab, a non-neutralizing antibody of adrenomedullin (ADM) was recently investigated regarding its potential to restore endothelial barrier function in septic shock patients with high plasma ADM levels. Circulating dipeptidyl peptidase 3
Externí odkaz:
https://doaj.org/article/9ceda969fd96492fab2f461288831bbd
Autor:
Hiromi Shiratori, Carmen Feinweber, Claudia Knothe, Jörn Lötsch, Dominique Thomas, Gerd Geisslinger, Michael J Parnham, Eduard Resch
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163184 (2016)
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is associated with various diseases including cancer. Many compounds have been reported to modify DNA methylation states. Despite increasing interest in
Externí odkaz:
https://doaj.org/article/18a68f7af3ff4c9ba40a3471623ac0c5
Autor:
Alfred Ultsch, Claudia Knothe, Mattias Kettner, Peter H. Schmidt, Bruno G. Oertel, Cora Wunder, Stefan W. Toennes, Jörn Lötsch, Gerd Geisslinger
Publikováno v:
Epigenomics. 8:1583-1599
Aim: Exposure to opioids has been associated with epigenetic effects. Studies in rodents suggested a role of varying degrees of DNA methylation in the differential regulation of μ-opioid receptor expression across the brain. Methods: In a translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeac422b9d9a217c2a415710aa018c9
https://doi.org/10.2217/epi-2016-0072
https://doi.org/10.2217/epi-2016-0072
Publikováno v:
Epigenomics. 8:167-179
Background: Increased global DNA methylation in the blood of patients chronically exposed to opioids had been interpreted as an indication of an epigenetic action of this drug class. Materials & methods: To strengthen the causality, human MCF7 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119789f061d286e99663d7db71f89708
https://doi.org/10.2217/epi.15.78
https://doi.org/10.2217/epi.15.78
Publikováno v:
Europe PubMed Central
The complexity of the sense of smell makes adverse olfactory effects of drugs highly likely, which can impact a patient's quality of life. Here, we present a bioinformatics approach that identifies drugs with potential olfactory effects by connecting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c19de87af1d0f07b61d0c03cb2c1095
https://doi.org/10.1016/j.drudis.2015.06.012
https://doi.org/10.1016/j.drudis.2015.06.012
Autor:
Alexandra Doehring, Alfred Ultsch, Claudia Knothe, Gerd Geisslinger, Jörn Lötsch, Eduard Resch, Hiromi Shiratori
Publikováno v:
Clinical Epigenetics
Background: The quantification of global DNA methylation has been established in epigenetic screening. As more practicable alternatives to the HPLC-based gold standard, the methylation analysis of CpG islands in repeatable elements (LINE-1) and the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39dfaa14262a77512457cb68274c7a3
https://pubmed.ncbi.nlm.nih.gov/27222668
https://pubmed.ncbi.nlm.nih.gov/27222668
Publikováno v:
Clinical pharmacokinetics. 55(7)
Abuse-deterrent formulations (ADFs) are technologically sophisticated pharmaceutical formulations that impede manipulation and extraction of opioids and/or provoke unpleasant effects when they are taken in excessive quantity. This is implemented by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca83c2161526b76fd3a24902e961e1f
https://pubmed.ncbi.nlm.nih.gov/26719075
https://pubmed.ncbi.nlm.nih.gov/26719075
Autor:
Claudia Knothe, Dominique Thomas, Hiromi Shiratori, Gerd Geisslinger, Jörn Lötsch, Carmen Feinweber, Eduard Resch, Michael J. Parnham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0163184 (2016)
PLoS ONE, Vol 11, Iss 10, p e0163184 (2016)
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is associated with various diseases including cancer. Many compounds have been reported to modify DNA methylation states. Despite increasing interest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c74cced42c9ced1920f1420722c421
https://publica.fraunhofer.de/handle/publica/246074
https://publica.fraunhofer.de/handle/publica/246074
Autor:
Nerea Ferreirós, Katrin Olbrich, Tanya S. King, Katharina L. Kynast, Ellen Niederberger, Gerd Geisslinger, Otto Quintus Russe, Claudia Knothe, Christine V. Möser
AMP-activated kinase (AMPK) is a cellular energy sensor, which is activated in stages of increased adenosine triphosphate (ATP) consumption. Its activation has been associated with a number of beneficial effects such as decrease of inflammatory proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d1332cc01ef4fa47814062c8f03031
https://publica.fraunhofer.de/handle/publica/247685
https://publica.fraunhofer.de/handle/publica/247685