Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Claudia Kettlun, Leyton"'
1
Akademický článek
Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy
Autor: Nahum Puebla-Osorio, Natalie Wall Fowlkes, Hampartsoum B. Barsoumian, Kristina Xega, Gitika Srivastava, Claudia Kettlun-Leyton, Sara Nizzero, Tiffany Voss, Thomas S. Riad, Christina Wong, Ailing Huang, Yun Hu, Joylise Mitchell, Mingee Kim, Zahid Rafiq, Kewen He, Duygu Sezen, Ethan Hsu, Fatemeh Masrorpour, Aurian Maleki, Carola Leuschner, Maria Angelica Cortez, Philipp Oertle, Marko Loparic, Marija Plodinec, Janet L. Markman, James W. Welsh
Publikováno v: Frontiers in Oncology, Vol 14 (2024)
IntroductionEffective infiltration of chimeric antigen receptor T (CAR-T) cells into solid tumors is critical for achieving a robust antitumor response and improving therapeutic outcomes. While CAR-T cell therapies have succeeded in hematologic malig
Externí odkaz: https://doaj.org/article/e15d8e28463245d5a2e2e3d70c939f5b
Zobrazit plný text záznamu
2
Akademický článek
Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer
Autor: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez, James W. Welsh
Publikováno v: Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One of the mechanisms of r
Externí odkaz: https://doaj.org/article/a090d791bef0465c93bf5eb25e2451f7
Zobrazit plný text záznamu
6
575 Dual blockade of LAG3 and TIGIT improves the treatment efficacy of a nanoparticle-mediated immunoradiation in anti-PD1 resistant lung cancer in mice
Autor: Kewen He, L. Yang, Yun Hu, Saumil Gandhi, Nahum Puebla-Osorio, Angelica Cortez, Duygu Sezen, Genevieve Bertolet, Claudia Kettlun Leyton, Lily Schuda, Sébastien Paris, Hampartsoum B. Barsoumian, Silva Jordan, Tiffany Voss, Fatemeh Masrorpour, Mark Wasley, Joylise Mitchell, James W. Welsh, Quynh-Nhu Nguyen
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTIGIT and LAG3 are inhibitory receptors expressed on cytotoxic CD8+ T cells and NK cells and directly inhibit the activation and proliferation of these cells. We proposed that blockade of TIGIT and LAG3 could improve antitumor immune respon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ce40af4bdeb20a51964f1cb4c00737
https://doi.org/10.1136/jitc-2021-sitc2021.575
Zobrazit plný text záznamu
9
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model
Autor: James M. Wilson, Ryan Himes, Xavier Legras, Peter Bell, Robert L. Kruse, Pradip K. Saha, Lili Wang, Karl-Dimiter Bissig, Hon-Chiu Eastwood Leung, Claudia Kettlun Leyton, William R. Lagor, Matthew C. Hill, Francis P. Pankowicz, Mercedes Barzi, Leon Chen, Beatrice Bissig-Choisat, John A. Goss, Lawrence Chan
Publikováno v: Nature communications. 6
Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c2031889ba1b29130366b263661407
https://pubmed.ncbi.nlm.nih.gov/26149614
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje