Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Claudia Igler"'
Publikováno v:
eLife, Vol 10 (2021)
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat. However, most such models consider resistance emergence via a single mutational step.
Externí odkaz:
https://doaj.org/article/221039238eed4c0cb2e2d164162e91b4
Autor:
Claudia Igler, Stephen T. Abedon
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/e957e73342fa4879a8ab885759775102
Prophages, viral sequences integrated into bacterial genomes, can be beneficial and costly. Despite the risk of prophage activation and subsequent bacterial death, active prophages are present in most bacterial genomes. However, our understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dca7a672736839a2b5ee7ab5a425d95
https://doi.org/10.1101/2023.03.21.533645
https://doi.org/10.1101/2023.03.21.533645
Autor:
Claudia Igler
Publikováno v:
Virus Evolution, 8 (2)
Bacteriophages, the viruses of bacteria, have been studied for over a century. They were not only instrumental in laying the foundations of molecular biology, but they are also likely to play crucial roles in shaping our biosphere and may offer a sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787470ec8589d9c60e753e17fab97dff
https://doi.org/10.1093/ve/veac086
https://doi.org/10.1093/ve/veac086
Antimicrobial resistance poses a rising threat to global health, making it crucial to understand the routes of bacterial survival during antimicrobial treatments. Treatment failure can result from genetic or phenotypic mechanisms, which diminish the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f941b9bf6f6b3c80520035f89a2e8d34
https://doi.org/10.1101/2022.04.07.487440
https://doi.org/10.1101/2022.04.07.487440
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences, 377 (1842)
Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences
Antibiotic resistance spread via plasmids is a serious threat to successfully fight infections and makes understanding plasmid transfer in nature crucial to prevent the rise of antibiotic resistance. Studies addressing the dynamics of plasmid conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c0cc4dbd6d947e93a8a2f83603767b
https://hdl.handle.net/20.500.11850/519641
https://hdl.handle.net/20.500.11850/519641
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences, 289 (1986)
To curb the rising threat of antimicrobial resistance, we need to understand the routes to antimicrobial treatment failure. Bacteria can survive treatment by using both genetic and phenotypic mechanisms to diminish the effect of antimicrobials. We as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a6fbb500e2b59771425452e37a24fb
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences
As infectious agents of bacteria and vehicles of horizontal gene transfer, plasmids play a key role in bacterial ecology and evolution. Plasmid dynamics are shaped not only by plasmid–host interactions but also by ecological interactions between pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::592e9061f8d4260830b7094d9171371a
https://pubmed.ncbi.nlm.nih.gov/34839701
https://pubmed.ncbi.nlm.nih.gov/34839701
Publikováno v:
Theoretical Computer Science, 893
Gene expression is regulated by the set of transcription factors (TFs) that bind to the promoter. The ensuing regulating function is often represented as a combinational logic circuit, where output (gene expression) is determined by current input val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4dabb3e083989c1aac0774317af3fc
https://hdl.handle.net/20.500.11850/512193
https://hdl.handle.net/20.500.11850/512193
Autor:
Florian M. Pauler, Balaji Santhanam, Gašper Tkačik, Claire Fourcade, Claudia Igler, Torsten Waldminghaus, Călin C. Guet
Reliable operation of cellular programs depends crucially on the specificity of biomolecular interactions. In gene regulatory networks, the appropriate expression of genes is determined through the specific binding of transcription factors (TFs) to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42aa30cb460bcd0ff9480553d767c6a
https://doi.org/10.1101/2021.10.20.465141
https://doi.org/10.1101/2021.10.20.465141