Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Claudia Hey"'
Evaluation of patient engagement in medicine development: A multi‐stakeholder framework with metrics
Autor:
Lidewij Eva Vat, Teresa Finlay, Paul Robinson, Giorgio Barbareschi, Mathieu Boudes, Ana Maria Diaz Ponce, Michaela Dinboeck, Lukas Eichmann, Elisa Ferrer, Sevgi E. Fruytier, Claudia Hey, Jacqueline E. W. Broerse, Tjerk Jan Schuitmaker‐Warnaar
Publikováno v:
Health Expectations, Vol 24, Iss 2, Pp 491-506 (2021)
Abstract Background Patient engagement is becoming more customary in medicine development. However, embedding it in organizational decision‐making remains challenging, partly due to lack of agreement on its value and the means to evaluate it. The o
Externí odkaz:
https://doaj.org/article/8ff825cf6d5b4b73b817914d42d378b9
Autor:
Lidewij Eva Vat, Teresa Finlay, Tjerk Jan Schuitmaker‐Warnaar, Nick Fahy, Paul Robinson, Mathieu Boudes, Ana Diaz, Elisa Ferrer, Virginie Hivert, Gabor Purman, Marie‐Laure Kürzinger, Robert A. Kroes, Claudia Hey, Jacqueline E.W. Broerse
Publikováno v:
Health Expectations, Vol 23, Iss 1, Pp 5-18 (2020)
Abstract Background Showing how engagement adds value for all stakeholders can be an effective motivator for broader implementation of patient engagement. However, it is unclear what methods can best be used to evaluate patient engagement. This paper
Externí odkaz:
https://doaj.org/article/8df63c658f5e47ac9a089979a3a5d5cd
Publikováno v:
Therapeutic innovationregulatory science.
Regulators and pharmaceutical companies across the world are intensifying efforts to get increasingly complex and innovative drugs to patients with high unmet medical need in the shortest possible time frame. This article reviews pathways to expedite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062b1bbe8e78bf0623cbb0804b221eba
https://pubmed.ncbi.nlm.nih.gov/36463352
https://pubmed.ncbi.nlm.nih.gov/36463352
Autor:
Claudia Hey, Elisa Ferrer, Tjerk Jan Schuitmaker-Warnaar, Teresa Finlay, Gabor Purman, Jacqueline E. W. Broerse, Mathieu Boudes, Virginie Hivert, Paul Robinson, Ana Diaz, Marie Laure Kürzinger, Nick Fahy, Robert A. Kroes, Lidewij Eva Vat
Publikováno v:
Health Expectations
Vat, L E, Finlay, T, Schuitmaker-Warnaar, T J, Fahy, N, Robinson, P, Boudes, M, Diaz, A, Ferrer, E, Hivert, V, Purman, G, Kürzinger, M L, Kroes, R A, Hey, C & Broerse, J E W 2019, ' Evaluating the "return on patient engagement initiatives" in medicines research and development : A literature review ', Health Expectations, vol. 23, no. 1, pp. 5-18 . https://doi.org/10.1111/hex.12951
Health Expectations, Vol 23, Iss 1, Pp 5-18 (2020)
Health Expectations : An International Journal of Public Participation in Health Care and Health Policy
Vat, L E, Finlay, T, Schuitmaker-Warnaar, T J, Fahy, N, Robinson, P, Boudes, M, Diaz, A, Ferrer, E, Hivert, V, Purman, G, Kürzinger, M L, Kroes, R A, Hey, C & Broerse, J E W 2019, ' Evaluating the "return on patient engagement initiatives" in medicines research and development : A literature review ', Health Expectations, vol. 23, no. 1, pp. 5-18 . https://doi.org/10.1111/hex.12951
Health Expectations, Vol 23, Iss 1, Pp 5-18 (2020)
Health Expectations : An International Journal of Public Participation in Health Care and Health Policy
Background Showing how engagement adds value for all stakeholders can be an effective motivator for broader implementation of patient engagement. However, it is unclear what methods can best be used to evaluate patient engagement. This paper is focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe63bb78af16d1e3a3917bbd4a3c01e
https://doi.org/10.1111/hex.12951
https://doi.org/10.1111/hex.12951
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 13:141-147
Alveolar macrophages (AMsmall ef, Cyrillic) express considerable arginase activity which can be modulated by various mediators. As inhibitors of phosphodiesterase (PDE) play an increasing role in the treatment of chronic inflammatory and obstructive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c762f3a1cbd19ee8868cff6b8730cdf
https://doi.org/10.1006/pupt.2000.0240
https://doi.org/10.1006/pupt.2000.0240
Autor:
Jutta Mössner, Kurt Racké, Gert Folkerts, Frans P. Nijkamp, Claudia Hey, Ignaz Wessler, Rainer Hammermann, Joachim Hirschmann
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 21:155-162
Eosinophil-derived cationic proteins play an essential role in the pathogenesis of bronchial asthma. We tested whether cationic proteins interfere with the cationic amino-acid transport in alveolar macrophages (AMPhi) and tracheal epithelial cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff008b96d17963b144df85103cc9dfd7
https://doi.org/10.1165/ajrcmb.21.2.3574
https://doi.org/10.1165/ajrcmb.21.2.3574
Activation of L-arginine transport by protein kinase C in rabbit, rat and mouse alveolar macrophages
Autor:
Jutta Mössner, Kurt Racké, Rainer Hammermann, Claudia Hey, Christina Stichnote, Ignaz Wessler
Publikováno v:
The Journal of Physiology. 511:813-825
1 The role of protein kinase C in controlling L-arginine transport in alveolar macrophages was investigated. 2 L-[3H]Arginine uptake in rabbit alveolar macrophages declined by 80 % after 20 h in culture. 4β-Phorbol 12-myristate 13-acetate (PMA), but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab41fcdae2aa91f396273f8b58187223
https://doi.org/10.1111/j.1469-7793.1998.813bg.x
https://doi.org/10.1111/j.1469-7793.1998.813bg.x
Autor:
Sandrine Vadon-Le Goff, Kurt Racké, Jean-Luc Boucher, Gabi Ketterer, Ignaz Wessler, Claudia Hey
Publikováno v:
British Journal of Pharmacology. 121:395-400
1. Alveolar macrophages (AM phi) exhibit arginase activity and may, in addition, express an inducible form of nitric oxide (NO) synthase (iNOS). Both pathways may compete for the substrate. L-arginine. The present study tested whether two recently de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af883ba61a8e9702f49458e53b047c92
https://doi.org/10.1038/sj.bjp.0701143
https://doi.org/10.1038/sj.bjp.0701143
Publikováno v:
European Journal of Pharmacology. 326:53-60
Effects of endogenous nitric oxide (NO) on the release of mediators of the lipoxygenase and cyclo-oxygenase pathway from rat alveolar macrophages were studied. Alveolar macrophages, freshly isolated or after 18-h culture, were incubated in (amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b036144d3ef6a48b67a9be50f207e27d
https://doi.org/10.1016/s0014-2999(97)00136-2
https://doi.org/10.1016/s0014-2999(97)00136-2
Publikováno v:
FEBS Letters. 359:251-254
The hypothesis was investigated that the nitric oxide (NO) synthase intermediate, NG-hydroxy-l-arginine (HOArg), is an arginase inhibitor in rabbit or rat alveolar macrophages. Exogenously applied HOArg strongly inhibited the arginase activity presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f8ad67b307f2400ece026a4948eeba
https://doi.org/10.1016/0014-5793(95)00039-c
https://doi.org/10.1016/0014-5793(95)00039-c