Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Claudia Höbartner"'
Autor:
Irene Bessi, Carina Stiller, Till Schroeder, Benedikt Schäd, Matthias Grüne, Julia Dietzsch, Claudia Höbartner
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1084-1093 (2024)
Externí odkaz:
https://doaj.org/article/5a610193e0b640baa18b746933e2de3b
Autor:
Adrian Chan, Isabel S. Naarmann-de Vries, Carolin P. M. Scheitl, Claudia Höbartner, Christoph Dieterich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Direct RNA sequencing offers the possibility to simultaneously identify canonical bases and epi-transcriptomic modifications in each single RNA molecule. Thus far, the development of computational methods has been hampered by the lack of bio
Externí odkaz:
https://doaj.org/article/325916d9dda74ff1b556e39e8d914fa0
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.
Externí odkaz:
https://doaj.org/article/b66a7c73278d4acdb1a5947679641b80
Autor:
Mateusz Mieczkowski, Christian Steinmetzger, Irene Bessi, Ann-Kathrin Lenz, Alexander Schmiedel, Marco Holzapfel, Christoph Lambert, Vladimir Pena, Claudia Höbartner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Fluorogenic RNA aptamers such as Chili display strong fluorescence enhancement upon aptamer–ligand complex formation. Here, the authors provide insights into the mechanism of fluorescence activation of Chili by solving the crystal structures of Chi
Externí odkaz:
https://doaj.org/article/6f5b09733cae41098a026686d5776e05
Autor:
Goran Kokic, Hauke S. Hillen, Dimitry Tegunov, Christian Dienemann, Florian Seitz, Jana Schmitzova, Lucas Farnung, Aaron Siewert, Claudia Höbartner, Patrick Cramer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Remdesivir is a nucleoside analog that inhibits the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and is used as a drug to treat COVID19 patients. Here, the authors provide insights into the mechanism of remdesivir-induced RdRp stalling by determini
Externí odkaz:
https://doaj.org/article/8b3f1fceaaca4cfa95f1314132c6731b
Autor:
Thomas Philipp Hoernes, Klaus Faserl, Michael Andreas Juen, Johannes Kremser, Catherina Gasser, Elisabeth Fuchs, Xinying Shi, Aaron Siewert, Herbert Lindner, Christoph Kreutz, Ronald Micura, Simpson Joseph, Claudia Höbartner, Eric Westhof, Alexander Hüttenhofer, Matthias David Erlacher
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The recognition of the mRNA codon by the tRNA anticodon is crucial for protein synthesis. Here the authors introduce non-standard nucleotides in bacterial and eukaryotic mRNA to reveal the minimal hydrogen bond requirement of codon-anticodon interact
Externí odkaz:
https://doaj.org/article/ffffbc1b3a5340bdb59935247e94c0d4
Publikováno v:
Molecules, Vol 25, Iss 16, p 3650 (2020)
Deoxyribozymes (DNAzymes) are small, synthetic, single-stranded DNAs capable of catalyzing chemical reactions, including RNA ligation. Herein, we report a novel class of RNA ligase deoxyribozymes that utilize 5′-adenylated RNA (5′-AppRNA) as the
Externí odkaz:
https://doaj.org/article/bfbdda7c33c249e3801cace3130c18f8
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 50-60 (2015)
Modifications of the nucleic acid backbone are essential for the development of oligonucleotide-derived bioactive agents. The NAA-modification represents a novel artificial internucleotide linkage which enables the site-specific introduction of posit
Externí odkaz:
https://doaj.org/article/fe88db2eea504042bbcf7c354d2bc4be
Publikováno v:
Bio-Protocol, Vol 7, Iss 17 (2017)
One of the most prominent applications of fluorescent super-resolution microscopy is the study of nanodomain arrangements of receptors and the endocytic pathway. Staining methods are becoming crucial for answering questions on the nanoscale, therefor
Externí odkaz:
https://doaj.org/article/d4fd95c5d80148d8a09bb9d24bba0508
Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0173050 (2017)
Continuous improvements in imaging techniques are challenging biologists to search for more accurate methods to label cellular elements. This is particularly relevant for diffraction-unlimited fluorescence imaging, where the perceived resolution is a
Externí odkaz:
https://doaj.org/article/8f2aeb2459014e6ba0431647de6b8575